Aging-associated sensory decline and Alzheimer's disease.

Autor: Hong S; The School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Baek SH; The School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Lai MKP; Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore, 117600, Singapore., Arumugam TV; The School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. g.arumugam@latrobe.edu.au.; Centre for Cardiovascular Biology and Disease Research, La Trobe Institute for Molecular Science, Department of Microbiology, Anatomy, Physiology and Pharmacology, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, 3086, Australia. g.arumugam@latrobe.edu.au., Jo DG; The School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. jodg@skku.edu.; Biomedical Institute for Convergence at SKKU (BICS), Suwon, 16419, Republic of Korea. jodg@skku.edu.; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06355, Republic of Korea. jodg@skku.edu.; Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, 16419, Republic of Korea. jodg@skku.edu.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2024 Dec 04; Vol. 19 (1), pp. 93. Date of Electronic Publication: 2024 Dec 04.

The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice.

Autor: Monteiro-Cardoso VF; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Translational Laboratories in Genetic Medicine, Agency for Science, Technology and Research, 138648, Singapore., Yeo XY; Institute for Molecular and Cellular Biology, Agency for Science, Technology and Research, 138667, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore., Bae HG; Institute for Molecular and Cellular Biology, Agency for Science, Technology and Research, 138667, Singapore; Department of Life Sciences, Yeungnam University, Gyeongsan 38541, South Korea., Mayan DC; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Translational Laboratories in Genetic Medicine, Agency for Science, Technology and Research, 138648, Singapore; Cardiovascular Research Institute, National University Health System, Singapore., Wehbe M; Institute of Basic Medical Sciences, University of Oslo, 0317 Norway., Lee S; Institute for Molecular and Cellular Biology, Agency for Science, Technology and Research, 138667, Singapore., Krishna-K K; Department of Physiology and Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University Singapore, 117593, Singapore., Baek SH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea., Palomera LF; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea., Wu LH; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore., Pakkiri LS; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore., Shanmugam S; Translational Laboratories in Genetic Medicine, Agency for Science, Technology and Research, 138648, Singapore., Sem KP; Translational Laboratories in Genetic Medicine, Agency for Science, Technology and Research, 138648, Singapore., Yew MG; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore., Parsons MP; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, A1B 3V6, Canada., Hayden MR; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada., Yeo LLL; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore., Sharma VK; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore., Drum C; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore., Liehn EA; Victor Babes National Institute of Pathology, Bucharest 050096, Romania; Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark., Sajikumar S; Department of Physiology and Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University Singapore, 117593, Singapore., Davanger S; Institute of Basic Medical Sciences, University of Oslo, 0317 Norway., Jo DG; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea., Chan MYY; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore., Tan BYQ; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore., Jung S; Institute for Molecular and Cellular Biology, Agency for Science, Technology and Research, 138667, Singapore; Department of Physiology and Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University Singapore, 117593, Singapore. Electronic address: jungsy0505@cha.ac.kr., Singaraja RR; Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Translational Laboratories in Genetic Medicine, Agency for Science, Technology and Research, 138648, Singapore; Cardiovascular Research Institute, National University Health System, Singapore. Electronic address: mdcrrs@nus.edu.sg.

Publikováno v: Journal of lipid research [J Lipid Res] 2024 Nov 20, pp. 100712. Date of Electronic Publication: 2024 Nov 20.

Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation.

Autor: Lee E; Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea., Lee Y; Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea.; Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, Republic of Korea., Yang S; Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea., Gong EJ; Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea., Kim J; Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea., Ha NC; Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Gwanak-gu, Seoul, 08826, Republic of Korea., Jo DG; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Mattson MP; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Lee J; Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea. neuron@pusan.ac.kr.

Publikováno v: Archives of pharmacal research [Arch Pharm Res] 2024 Nov; Vol. 47 (10-11), pp. 812-828. Date of Electronic Publication: 2024 Sep 26.

Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas-based epigenome editing in Alzheimer's disease.

Autor: Han J; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Sul JH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Lee J; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Kim E; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Kim HK; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Chae M; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Lim J; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Kim J; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Kim C; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Kim JS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Cho Y; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea., Park JH; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 16419, Korea.; Biomedical Institute for Convergence, Sungkyunkwan University, Suwon 16419, Korea.; ExoStem Tech Inc., Ansan 15588, Korea.; Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, Korea., Cho YW; ExoStem Tech Inc., Ansan 15588, Korea.; Department of Chemical Engineering, Hanyang University, Ansan 15588, Korea., Jo DG; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.; Biomedical Institute for Convergence, Sungkyunkwan University, Suwon 16419, Korea.; ExoStem Tech Inc., Ansan 15588, Korea.; Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06351, Korea.; Institute of Quantum Biophysics, Sungkyunkwan University, Suwon 16419, Korea.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Aug 07; Vol. 16 (759), pp. eadi4830. Date of Electronic Publication: 2024 Aug 07.

Stem Cell-Derived Extracellular Vesicle-Bearing Injectable Hydrogel for Collagen Generation in Dermis.

Autor: You DG; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States., Jung JM; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea., Kim CH; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea., An JY; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea., Bui VD; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea., Lee J; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea., Um W; Department of Biotechnology, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea., Jo DG; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.; School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.; ExoStemTech Inc., 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, Republic of Korea., Cho YW; ExoStemTech Inc., 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, Republic of Korea.; Department of Materials Science and Chemical Engineering, Hanyang University ERICA, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, Republic of Korea., Lee DS; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea., Balaj L; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States., Lee H; Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Park JH; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.; ExoStemTech Inc., 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, Republic of Korea.

Publikováno v: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Jul 24; Vol. 16 (29), pp. 37698-37706. Date of Electronic Publication: 2024 Jul 09.