Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jo C Martindale"'
Publikováno v:
Pain. 128:78-87
There are several lines of evidence to suggest that cyclooxygenase-2 (COX-2) plays an important role in the generation and maintenance of neuropathic pain states following peripheral nerve injury. However, COX-2 inhibitors are generally ineffective i
Autor:
Simon T. Bate, Sue D. Collins, Jo C Martindale, Caroline J Sharp, Scott G. Summerfield, Alison J Reeve, Iain P. Chessell, Becky Sargent
Publikováno v:
British Journal of Pharmacology. 148:845-852
1. Two P2X(3)/P2X(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. 2. A-317491 has poor CNS penetrance (blood:brain, 1
Publikováno v:
Pain. 133(1-3)
Intra-articular injection of Freund's complete adjuvant (FCA) into the rat knee joint produces a swelling of the joint and long lasting hypersensitivity. In this study we have used this model and in vivo electrophysiology to investigate the time cour
Autor:
Caroline J, Sharp, Alison J, Reeve, Sue D, Collins, Jo C, Martindale, Scott G, Summerfield, Becky S, Sargent, Simon T, Bate, Iain P, Chessell
Publikováno v:
British journal of pharmacology. 148(6)
1. Two P2X(3)/P2X(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. 2. A-317491 has poor CNS penetrance (blood:brain, 1:0.05), and was therefore administered intravenously in chron