Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jo Anne Saye"'
Publikováno v:
Emerging Therapeutic Targets. 4:377-396
Nuclear receptors (NR) are transcription factors that are regulated by ligand binding. Several members of this family regulate glucose and lipid metabolism in vivo and consequently play a major role in the overall energy balance of the host. Serendip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81612bab15657c90c77098d79c39103b
https://doi.org/10.1517/14728222.4.3.377
https://doi.org/10.1517/14728222.4.3.377
Autor:
Ronald M. Klabe, James D. Rodgers, Jo Anne Saye, Susan Jeffrey, Sharon Diamond, Jeffrey W. Corbett, Paul Anderson, Chii-Ming Lai, Soo S. Ko, Susan Erickson-Viitanen, Lee T. Bacheler, George L. Trainor, Shelley R. Rabel, Stephen P. Adams
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:2893-2897
A research program targeted toward the identification of expanded-spectrum nonnucleoside reverse transcriptase inhibitors which possess increased potency toward K103N-containing mutant human immunodeficiency virus (HIV) and which maintain pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567388c7341616f0be0df6009f06e718
https://doi.org/10.1128/aac.43.12.2893
https://doi.org/10.1128/aac.43.12.2893
Autor:
Xuan Yuan, Amy E. DeZern, Jeffrey J. Pu, Marc E. Uknis, Robert A. Brodsky, Galina L. Mukhina, Juan Carlos Varela, Jo Anne Saye
Publikováno v:
Experimental hematology. 42(10)
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, clonal, hematopoietic stem cell disorder that manifests with a complement-mediated hemolytic anemia, bone marrow failure and a propensity for thrombosis. These patients experience both intra- and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3103be7d8130b209be204d83db7c45ec
https://pubmed.ncbi.nlm.nih.gov/25034232
https://pubmed.ncbi.nlm.nih.gov/25034232
Autor:
Lawrence W. Fitzgerald, George L. Trainor, Jo Anne Saye, Paul J. Gilligan, Ned H. Kalin, Robert Zaczek, H-S. L. Shen, David D. Christ, Paul R. Hartig, Steven E. Shelton, John F. McElroy, Liqi He
Publikováno v:
Journal of medicinal chemistry. 43(3)
Structure-activity studies in the pyrazolo[1,5-a]-1,3,5-triazine series led to the discovery that compound 11i (DMP696) is a potent hCRF(1) receptor antagonist (K(i) = 1.7 nM vs 7.5 nM for alpha-hel-CRF(9-41), hCRF(1) adenylate cyclase IC(50) = 82 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0130e3f8189aa3ce7b5fb9d3dfdc01b
https://pubmed.ncbi.nlm.nih.gov/10669572
https://pubmed.ncbi.nlm.nih.gov/10669572
Publikováno v:
Journal of Vascular Research. 21:223-230
Endothelium-dependent relaxation in rabbit aorta was inhibited by exposure to two cytochrome P-450 inhibitors, metyrapone and SKF-525A. Aortic rings were contracted to a stable plateau by addition of phenylephrine (10–7M). Relaxation was elicited b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb6327ea97135bf43fdcbea29e530db
https://doi.org/10.1159/000158515
https://doi.org/10.1159/000158515