Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jo Anne Saye"'
Publikováno v:
Emerging Therapeutic Targets. 4:377-396
Nuclear receptors (NR) are transcription factors that are regulated by ligand binding. Several members of this family regulate glucose and lipid metabolism in vivo and consequently play a major role in the overall energy balance of the host. Serendip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81612bab15657c90c77098d79c39103b
https://doi.org/10.1517/14728222.4.3.377
https://doi.org/10.1517/14728222.4.3.377
Autor:
Ronald M. Klabe, James D. Rodgers, Jo Anne Saye, Susan Jeffrey, Sharon Diamond, Jeffrey W. Corbett, Paul Anderson, Chii-Ming Lai, Soo S. Ko, Susan Erickson-Viitanen, Lee T. Bacheler, George L. Trainor, Shelley R. Rabel, Stephen P. Adams
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:2893-2897
A research program targeted toward the identification of expanded-spectrum nonnucleoside reverse transcriptase inhibitors which possess increased potency toward K103N-containing mutant human immunodeficiency virus (HIV) and which maintain pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567388c7341616f0be0df6009f06e718
https://doi.org/10.1128/aac.43.12.2893
https://doi.org/10.1128/aac.43.12.2893
Autor:
Xuan Yuan, Amy E. DeZern, Jeffrey J. Pu, Marc E. Uknis, Robert A. Brodsky, Galina L. Mukhina, Juan Carlos Varela, Jo Anne Saye
Publikováno v:
Experimental hematology. 42(10)
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, clonal, hematopoietic stem cell disorder that manifests with a complement-mediated hemolytic anemia, bone marrow failure and a propensity for thrombosis. These patients experience both intra- and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3103be7d8130b209be204d83db7c45ec
https://pubmed.ncbi.nlm.nih.gov/25034232
https://pubmed.ncbi.nlm.nih.gov/25034232
Autor:
Lawrence W. Fitzgerald, George L. Trainor, Jo Anne Saye, Paul J. Gilligan, Ned H. Kalin, Robert Zaczek, H-S. L. Shen, David D. Christ, Paul R. Hartig, Steven E. Shelton, John F. McElroy, Liqi He
Publikováno v:
Journal of medicinal chemistry. 43(3)
Structure-activity studies in the pyrazolo[1,5-a]-1,3,5-triazine series led to the discovery that compound 11i (DMP696) is a potent hCRF(1) receptor antagonist (K(i) = 1.7 nM vs 7.5 nM for alpha-hel-CRF(9-41), hCRF(1) adenylate cyclase IC(50) = 82 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0130e3f8189aa3ce7b5fb9d3dfdc01b
https://pubmed.ncbi.nlm.nih.gov/10669572
https://pubmed.ncbi.nlm.nih.gov/10669572
Publikováno v:
Journal of Vascular Research. 21:223-230
Endothelium-dependent relaxation in rabbit aorta was inhibited by exposure to two cytochrome P-450 inhibitors, metyrapone and SKF-525A. Aortic rings were contracted to a stable plateau by addition of phenylephrine (10–7M). Relaxation was elicited b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb6327ea97135bf43fdcbea29e530db
https://doi.org/10.1159/000158515
https://doi.org/10.1159/000158515
Publikováno v:
Journal of Vascular Research; 1984, Vol. 21 Issue 5, p223-230, 8p
Publikováno v:
American Journal of Physiology: Cell Physiology; Jun1993, Vol. 264 Issue 6, pC1570-C1576, 7p
Publikováno v:
Hypertension (0194911X); Mar/Apr1984, Vol. 6 Issue 2, p216-221, 6p
Autor:
JOHNS, ROGER A., MILNER, PETER J., IZZO, NICHOLAS J., SAYE, JOANNE, LOEB, ALEX L., PEACH, MICHAEL J.
Publikováno v:
Annals of the New York Academy of Sciences; 1989, Vol. 559 Issue 1, p455-456, 2p
Autor:
J.M. Saavedra, P.B.M.W.M. Timmermans
From molecular biology to clinical applications of selective receptor blockade, the present volume compiles the latest advances of this emerging field. Of particular importance is the attention given to the newly discovered AT2 receptors, and the phy
