Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jo Anne Hongo"'
Autor:
Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta
Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized Glial cell line–Derived Neurotroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ebbf88322d045b6d0c4b08c2c22021d
https://doi.org/10.1158/1535-7163.c.6537960.v1
https://doi.org/10.1158/1535-7163.c.6537960.v1
Autor:
Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta
Figure S1. Validation of anti-GFRA1 antibodies (R&D systems and GNE-8H6) for the use of Immunohistochemistry (IHC) analysis; Figure S2. ELISA analyses to test binding specificity of anti-GFRA1 antibodies to GFRA1 (A) and GFRA2 (B) extra cellular doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100a6557ca8c0f2a229a1ced8e41d71e
https://doi.org/10.1158/1535-7163.22505118
https://doi.org/10.1158/1535-7163.22505118
Autor:
Marcy R Auerbach, Donghong Yan, Rajesh Vij, Jo-Anne Hongo, Gerald Nakamura, Jean-Michel Vernes, Y Gloria Meng, Samantha Lein, Pamela Chan, Jed Ross, Richard Carano, Rong Deng, Nicholas Lewin-Koh, Min Xu, Becket Feierbach
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004060 (2014)
Human cytomegalovirus (HCMV) is the most common cause of congenital virus infection. Congenital HCMV infection occurs in 0.2-1% of all births, and causes birth defects and developmental abnormalities, including sensorineural hearing loss and developm
Externí odkaz:
https://doaj.org/article/ba33e7d6b927441a9bc774597b8ee3e5
Autor:
Marinella G Callow, Hoanh Tran, Lilian Phu, Ted Lau, James Lee, Wendy N Sandoval, Peter S Liu, Sheila Bheddah, Janet Tao, Jennie R Lill, Jo-Anne Hongo, David Davis, Donald S Kirkpatrick, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22595 (2011)
Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation. This function of
Externí odkaz:
https://doaj.org/article/dd787cda777a424996475d2d515fd403
Autor:
James A. Ernst, Christoph Spiess, Angie Yee, Hok Seon Kim, Jo-Anne Hongo, Ingrid Kim, Raymond K. Tong, Diana Ronai Dunshee, Farzam Farahi, Junichiro Sonoda
Publikováno v:
Protein Engineering, Design and Selection
Bispecific antibodies offer a clinically validated platform for drug discovery. In generating functionally active bispecific antibodies, it is necessary to identify a unique parental antibody pair to merge into a single molecule. However, technologie
Autor:
Ciara Metcalfe, Yan Wu, Jo Anne Hongo, Jarrod Tremayne, Noelyn M. Kljavin, Elizabeth Blackwood, Elaine E. Storm, Robert L. Yauch, Eric Stawiski, Felipe De Sousa E Melo, Ron Firestein, Cecilia Chiu, Travis W. Bainbridge, Christine Tan, Steffen Durinck, Xiaofen Ye, Frederic J. de Sauvage, Thinh S Pham
Publikováno v:
Nature. 529:97-100
Colorectal cancer remains a major unmet medical need, prompting large-scale genomics efforts in the field to identify molecular drivers for which targeted therapies might be developed. We previously reported the identification of recurrent translocat
Autor:
Sunil Bhakta, Lisa M. Crocker, Yvonne Chen, Meredith Hazen, Melissa M. Schutten, Dongwei Li, Coenraad Kuijl, Rachana Ohri, Fiona Zhong, Kirsten A. Poon, Mary Ann T. Go, Eric Cheng, Robert Piskol, Ron Firestein, Aimee Fourie-O'Donohue, Katherine R. Kozak, Helga Raab, Jo-Anne Hongo, Deepak Sampath, Mark S. Dennis, Richard H. Scheller, Paul Polakis, Jagath R. Junutula
Publikováno v:
Molecular Cancer Therapeutics. 18:2182-2182
Autor:
Ron Firestein, Yvonne Chen, Rachana Ohri, Richard H. Scheller, Helga Raab, Katherine R. Kozak, Paul Polakis, Coenraad Kuijl, Dongwei Li, Meredith Hazen, Lisa Crocker, Robert Piskol, Mark S. Dennis, Jagath Reddy Junutula, Eric Cheng, Deepak Sampath, Kirsten Achilles Poon, Aimee Fourie-O'Donohue, Sunil Bhakta, Fiona Zhong, Melissa Schutten, Mary Ann T. Go, Jo-Anne Hongo
Publikováno v:
Bhakta, S, Crocker, L M, Chen, Y, Hazen, M, Schutten, M M, Li, D, Kuijl, C, Ohri, R, Zhong, F, Poon, K A, Go, M A T, Cheng, E, Piskol, R, Firestein, R, Fourie-O'Donohue, A, Kozak, K R, Raab, H, Hongo, J-A, Sampath, D, Dennis, M S, Scheller, R H, Polakis, P & Junutula, J R 2018, ' An anti-gdnf family receptor alpha 1 (gfra1 antibody–drug conjugate for the treatment of hormone receptor–positive breast cancer ', Molecular Cancer Therapeutics, vol. 17, no. 3, pp. 638-649 . https://doi.org/10.1158/1535-7163.MCT-17-0813
Molecular Cancer Therapeutics, 17(3), 638-649. American Association for Cancer Research Inc.
Molecular Cancer Therapeutics, 17(3), 638-649. American Association for Cancer Research Inc.
Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized Glial cell line–Derived Neurotroph
Autor:
Bing Li, Jagath Reddy Junutula, Karen E. Ervin, Meredith Hazen, Dara Y. Kallop, Jo-Anne Hongo, Vicki Chiang, Rajesh Vij, Robby M. Weimer, Bijay S. Jaiswal, Richard H. Scheller, Steven Randle, Paul Polakis, Sunil Bhakta, Isidro Hötzel
Publikováno v:
mAbs. 6:95-107
Multi-transmembrane proteins are especially difficult targets for antibody generation largely due to the challenge of producing a protein that maintains its native conformation in the absence of a stabilizing membrane. Here, we describe an immunizati
Autor:
Kim Newton, Sarah G. Hymowitz, XiaoDong Huang, Anthony Wynshaw-Boris, Michael Kakunda, Christine Yu, Paul Polakis, Victoria Pham, Jo Anne Hongo, Jennie R. Lill, Bob Y. Liu, Rami N. Hannoush, Richard M. Harland, James C. McGann, Jinfeng Liu, Vishva M. Dixit
Publikováno v:
Science. 339:1441-1445
Receptor interacting protein kinase 4 (RIPK4) is required for epidermal differentiation (1–4) and is mutated in Bartsocas-Papas syndrome (5, 6). While RIPK4 binds protein kinase C (5, 6), RIPK4 signaling mechanisms are largely unknown. We show that