Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jo Ann M. Tufariello"'
Autor:
Gregory M. Cook, Dannah Rae Sajorda, Erik J. Hasenoehrl, Linda Berney-Meyer, Samantha Johnson, William R. Jacobs, Michael Berney, Jo Ann M. Tufariello, Tobias Fuhrer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications, 10
Nature Communications
Nature Communications, 10
A major constraint for developing new anti-tuberculosis drugs is the limited number of validated targets that allow eradication of persistent infections. Here, we uncover a vulnerable component of Mycobacterium tuberculosis (Mtb) persistence metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f034879ec17247ab76676d529a304c
http://link.springer.com/article/10.1038/s41467-019-12224-3
http://link.springer.com/article/10.1038/s41467-019-12224-3
Autor:
Lorenza Favrot, Adel A. Malek, Olivia Vergnolle, John S. Blanchard, Hua Xu, Jo Ann M. Tufariello, William R. Jacobs
Publikováno v:
Journal of Biological Chemistry. 291:22315-22326
Iron is an essential element for life, but its soluble form is scarce in the environment and is rarer in the human body. Mtb (Mycobacterium tuberculosis) produces two aryl-capped siderophores, mycobactin (MBT) and carboxymycobactin (cMBT), to chelate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6e35afeb9a94daf0d113b343ea04c1
https://doi.org/10.1074/jbc.m116.744532
https://doi.org/10.1074/jbc.m116.744532
Autor:
William R. Jacobs, Emir Tinaztepe, Christopher M. Jones, Jennifer A. Philips, Victor Thompson, Laura E. Cole, Michael Niederweis, Jo Ann M. Tufariello, Jessica R. Chapman, Catherine Vilchèze, Beatrix Ueberheide, Christopher A. Kerantzas, Ka-Wing Wong, David Fenyö
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS), designated ESX-1-ESX-5, that are critical for growth and pathogenesis. The best characterized is ESX-1, which profoundly impacts host cell interactions. In contrast, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1613da093411a30ab9c227b3f0adcfa5
https://doi.org/10.1073/pnas.1523321113
https://doi.org/10.1073/pnas.1523321113
The aerosol rabbit model of TB latency, reactivation and immune reconstitution inflammatory syndrome
Autor:
Susana Mendez, Yukari C. Manabe, Anup Kumar Kesavan, Christine L. Hatem, John Chan, M. Louise M. Pitt, Jo Ann M. Tufariello, Ricardo Toshio Fujiwara, Javier Lopez-Molina, Karl Hochstein, Arthur M. Dannenberg, William R. Bishai, Megan Brooks, David N. McMurray
Publikováno v:
Tuberculosis. 88:187-196
The large reservoir of human latent tuberculosis (TB) contributes to the global success of the pathogen, Mycobacterium tuberculosis (Mtb). We sought to test whether aerosol infection of rabbits with Mtb H37Rv could model paucibacillary human latent T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a0f064d6d0277d5cdd221773bf29d2
https://doi.org/10.1016/j.tube.2007.10.006
https://doi.org/10.1016/j.tube.2007.10.006
Autor:
Joshua E. Drumm, Kathryn E. Tanaka, Anup Kumar Kesavan, Jo Ann M. Tufariello, Kaixia Mi, Jiayong Xu, Yukari C. Manabe, William R. Jacobs, John Chan
Publikováno v:
Infection and Immunity. 74:2985-2995
Approximately one-third of the human population is latently infected withMycobacterium tuberculosis, comprising a critical reservoir for disease reactivation. Despite the importance of latency in maintainingM. tuberculosisin the human population, lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb86448a7dd3407b6a9ba57dc5eefaf
https://doi.org/10.1128/iai.74.5.2985-2995.2006
https://doi.org/10.1128/iai.74.5.2985-2995.2006
Autor:
Jo Ann M. Tufariello, Guofeng Zhu, Soumya D. Chakravarty, JoAnne L. Flynn, Jiayong Xu, Ming C. Tsai, Kathryn E. Tanaka, John W. Y. Chan, Cameron J. Koch
Publikováno v:
Cellular Microbiology. 8:218-232
The granulomatous reaction is the hallmark of the host response to infection with Mycobacterium tuberculosis. Despite its apparent importance to host defence against the tubercle bacillus, the granulomatous response remains to be completely defined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148805a26ff67534937c0b16a38988ee
https://doi.org/10.1111/j.1462-5822.2005.00612.x
https://doi.org/10.1111/j.1462-5822.2005.00612.x
Publikováno v:
Infection and Immunity. 72:515-526
Mycobacterium tuberculosispossesses five genes with significant homology to the resuscitation-promoting factor (Rpf) ofMicrococcus luteus. TheM. luteusRpf is a secreted ∼16-kDa protein which restores active growth to cultures ofM. luteusrendered do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf6c101e88425f06ccc93f49ce29ae1
https://doi.org/10.1128/iai.72.1.515-526.2004
https://doi.org/10.1128/iai.72.1.515-526.2004
Autor:
Pablo A. González, Adel A. Malek, William R. Jacobs, Paras Jain, Laura E. Cole, Jo Ann M. Tufariello, Hannah K. Ratner, Catherine Vilchèze, Michelle H. Larsen, Graham F. Hatfull
Publikováno v:
mBio
mBio, Vol 5, Iss 3 (2014)
mBio, Vol 5, Iss 3 (2014)
Genetic engineering has contributed greatly to our understanding of Mycobacterium tuberculosis biology and has facilitated antimycobacterial and vaccine development. However, methods to generate M. tuberculosis deletion mutants remain labor-intensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb32fb7a4ed90e27593614a124a181e
https://doi.org/10.1128/mbio.01179-14
https://doi.org/10.1128/mbio.01179-14
As previously published, after aerosol infection with Mycobacterium tuberculosis H37Rv, New Zealand white rabbits established infection with active bacillary replication, but later contained disease to a paucibacillary state through an effective adap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba78a60f2876a54b1c1159bac8366170
https://europepmc.org/articles/PMC2655131/
https://europepmc.org/articles/PMC2655131/
Publikováno v:
The Lancet. Infectious diseases. 3(9)
Most people infected with Mycobacterium tuberculosis contain the initial infection and develop latent tuberculosis. This state is characterised by evidence of an immune response against the bacterium (a positive tuberculin skin test) but no signs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053afd3cd8896c6b26218aceac13f718
https://pubmed.ncbi.nlm.nih.gov/12954564
https://pubmed.ncbi.nlm.nih.gov/12954564