Výsledky vyhledávání - "Jo A. Salisbury"

P‐glycoprotein Influences the Brain Concentrations of Cetirizine (Zyrtec®), a Second‐Generation Non‐Sedating Antihistamine

Autor: Jo A. Salisbury, Joan E. Humphreys, Cosette J. Serabjit-Singh, Todd M. Baughman, Timothy K. Tippin, Kelly H. Jordan, Joseph W. Polli, Angela L. Mote

Publikováno v: Journal of Pharmaceutical Sciences. 92:2082-2089

Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concentrations of non-sedating (second-generation) antihistamines. The purpose of this study was to determine the importance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5448bc4ec1f72563033849add475017
https://doi.org/10.1002/jps.10453

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Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity

Autor: Deborah A. Winegar, Carl W. Sigel, James Chapman, Jo A. Salisbury, Roy L. Hawke, Alan Robert Brown, Richard M. Welch, Karl Witold Franzmann

Publikováno v: Journal of Lipid Research, Vol 38, Iss 6, Pp 1189-1203 (1997)

The hypocholesterolemic activity for novel ureido fibrate analogues was found to be over 100-fold greater than for any “second-generation” fibrate in cholesterol-fed rats. A comparison of 12 related analogues revealed that the optimal configurati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5541442dfd2e4e477f3eab885edfdd
https://doi.org/10.1016/s0022-2275(20)37201-1

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Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells

Autor: Jo A. Salisbury, Scott S. Sundseth, Deborah A. Winegar, Roy L. Hawke

Publikováno v: Journal of Lipid Research, Vol 37, Iss 1, Pp 179-191 (1996)
Scopus-Elsevier

The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. 27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab68400435c40b89943e4f3bcb57dfdc
https://doi.org/10.1016/s0022-2275(20)37646-x

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Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir

Autor: Dan Todd, Scott D. Studenberg, Andy D. Searle, Furfine Eric Steven, Michael R. Hale, Baker Christopher T, Andrew Spaltenstein, David J. Reynolds, Jo A. Salisbury, Roger D. Tung

GW433908 is the water-soluble, phosphate ester prodrug of the human immunodeficiency virus type 1 protease inhibitor amprenavir (APV). A high-yield synthesis of GW433908 is achieved by phosphorylation of the penultimate precursor of APV with phosphor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbaff72a32b5cdd402202b5c4e5f945
https://europepmc.org/articles/PMC353103/