Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jo‐Anne Baltos"'
Autor:
Anh T. N. Nguyen, Quan L. Tran, Jo-Anne Baltos, Samantha M. McNeill, Diep T. N. Nguyen, Lauren T. May
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
G protein-coupled receptors (GPCRs) represent the target for approximately a third of FDA-approved small molecule drugs. The adenosine A1 receptor (A1R), one of four adenosine GPCR subtypes, has important (patho)physiological roles in humans. A1R has
Externí odkaz:
https://doaj.org/article/81d31d2e60944c6584c40e60fa79d4a9
Publikováno v:
Purinergic Signalling. 18:359-381
Alzheimer’s disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment challenges. Despite a better understanding of the disease, the current mainstay of treatment cannot modify pathogenesis or effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2efdb0fb69156016916fc1dc499d090f
https://doi.org/10.1007/s11302-022-09883-1
https://doi.org/10.1007/s11302-022-09883-1
Autor:
Jo‐Anne Baltos, Pablo M. Casillas‐Espinosa, Ben Rollo, Karen J. Gregory, Paul J. White, Arthur Christopoulos, Patrick Kwan, Terence J. O'Brien, Lauren T. May
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70a8425ab851eb752c9615e13d4c5b9e
https://doi.org/10.1111/bph.16094
https://doi.org/10.1111/bph.16094
Autor:
Pierre Matricon, Anh TN. Nguyen, Duc Duy Vo, Jo-Anne Baltos, Mariama Jaiteh, Andreas Luttens, Stefanie Kampen, Arthur Christopoulos, Jan Kihlberg, Lauren Therese May, Jens Carlsson
Publikováno v:
European Journal of Medicinal Chemistry. :115419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a588696fd5c308e866cdd5022398cf66
https://doi.org/10.1016/j.ejmech.2023.115419
https://doi.org/10.1016/j.ejmech.2023.115419
Publikováno v:
Purinergic Signalling. 18:407-407
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd29aa1b43cd2c71701633a9fc02a658
https://doi.org/10.1007/s11302-022-09906-x
https://doi.org/10.1007/s11302-022-09906-x
Autor:
Richard I. Webb, Jo-Anne Baltos, Arthur Christopoulos, James L. Mead, Sachini Fonseka, Nicole S. Bryce, Han-Hao Cheng, Thomas E. Hall, Charles Ferguson, Edna C. Hardeman, Peter W. Gunning, Nicholas Ariotti, Yann Gambin, James Rae, James D. Riches, Dominic J. B. Hunter, Marcel Ethan Sayre, Maria Lastra Cagigas, Robert G. Parton, Nick Martel
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Genetic tags allow rapid localization of tagged proteins in cells and tissues. APEX, an ascorbate peroxidase, has proven to be one of the most versatile and robust genetic tags for ultrastructural localization by electron microscopy (EM). Here, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef42a4f7d09d192dbe3babf3f24ae189
https://doi.org/10.7554/elife.64630
https://doi.org/10.7554/elife.64630
Autor:
Thomas E. Hall, Edna C. Hardeman, Jo-Anne Baltos, Richard I. Webb, Nicole S. Bryce, Nicholas Ariotti, Maria Lastra Cagigas, Marcel Ethan Sayre, Arthur Christopoulos, Dominic J. B. Hunter, Peter W. Gunning, Charles Ferguson, Yann Gambin, Robert G. Parton, James L. Mead, Nick Martel, James Rae, Han-Hao Cheng, Sachini Fonseka, James D. Riches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3397ada8fb0b4476fc479bf4e42a4c0d
https://doi.org/10.7554/elife.64630.sa2
https://doi.org/10.7554/elife.64630.sa2
Autor:
Nicholas Ariotti, Maria Lastra Cagigas, Robert G. Parton, Nick Martel, Arthur Christopoulos, Han-Hao Cheng, Charles Ferguson, Richard I. Webb, James Rae, Sachini Fonseka, Dominic J. B. Hunter, Nicole S. Bryce, Yann Gambin, James L. Mead, Jo-Anne Baltos, Jamie Riches, Thomas E. Hall, Edna C. Hardeman, Peter W. Gunning
Genetic tags allow rapid localization of tagged proteins in cells and tissues. APEX, an ascorbate peroxidase, has proven to be one of the most versatile and robust genetic tags for ultrastructural localization by electron microscopy. Here we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e13bcc48f3b873961178a89f6af6c21c
https://doi.org/10.1101/2020.10.06.328831
https://doi.org/10.1101/2020.10.06.328831
Autor:
Arthur Christopoulos, Yi Lynn Liang, Jo-Anne Baltos, Jürgen M. Plitzko, Denise Wootten, Christopher J Draper-Joyce, David M. Thal, Hariprasad Venugopal, Alisa Glukhova, Sebastian G.B. Furness, Maryam Khoshouei, Wolfgang Baumeister, Lauren T. May, Radostin Danev, Patrick M. Sexton, Anh Nguyen
Publikováno v:
Nature. 558:559-563
The class A adenosine A1 receptor (A1R) is a G-protein-coupled receptor that preferentially couples to inhibitory Gi/o heterotrimeric G proteins, has been implicated in numerous diseases, yet remains poorly targeted. Here we report the 3.6 A structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9ed448cccfd3dc00b08ff628afcd20
https://doi.org/10.1038/s41586-018-0236-6
https://doi.org/10.1038/s41586-018-0236-6
Autor:
Arthur Christopoulos, Peter J. Scammells, Celine Valant, Manuela Jörg, Luigi Aurelio, Shane M. Devine, Leigh Ford, Jo-Anne Baltos, Paul J. White, Anh Nguyen, Lauren T. May
Publikováno v:
Journal of Medicinal Chemistry. 61:2087-2103
The adenosine A1 receptor (A1AR) is a potential novel therapeutic target for myocardial ischemia-reperfusion injury. However, to date, clinical translation of prototypical A1AR agonists has been hindered due to dose limiting adverse effects. Recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bfc5b931fa410da636d6989e5931583
https://doi.org/10.1021/acs.jmedchem.8b00047
https://doi.org/10.1021/acs.jmedchem.8b00047