Molecular profile of pure squamous cell carcinoma of the bladder identifies major roles for OSMR and YAP signalling

Autor: Carolyn D Hurst, Guo Cheng, Fiona M Platt, Olivia Alder, Emma VI Black, Julie E Burns, Joanne Brown, Sunjay Jain, Jo‐An Roulson, Margaret A Knowles

Publikováno v: The Journal of Pathology: Clinical Research, Vol 8, Iss 3, Pp 279-293 (2022)

Abstract Pure squamous cell carcinoma (SCC) is the most common pure variant form of bladder cancer, found in 2–5% of cases. It often presents late and is unresponsive to cisplatin‐based chemotherapy. The molecular features of these tumours have n

Externí odkaz: https://doaj.org/article/37062d89cb4f4c22859e462534494f59

Polycomb Repressor Complex 1 Member, BMI1 Contributes to Urothelial Tumorigenesis through p16-Independent Mechanisms

Autor: Lia E. De Faveri, Carolyn D. Hurst, Jo-An Roulson, Henry Wood, Marta Sanchez-Carbayo, Margaret A. Knowles, Emma J. Chapman

Publikováno v: Translational Oncology, Vol 8, Iss 5, Pp 387-399 (2015)

Urothelial carcinoma (UC) causes significant morbidity and remains the most expensive cancer to treat because of the need for repeated resections and lifelong monitoring for patients with non–muscle-invasive bladder cancer (NMIBC). Novel therapeuti

Externí odkaz: https://doaj.org/article/cd6575674005407591b8cc9d354be785

Supplementary Table 1 from Alteration of Cell–Cell and Cell–Matrix Adhesion in Urothelial Cells: An Oncogenic Mechanism for Mutant FGFR3

Autor: Margaret A. Knowles, Jo-An Roulson, Gavin Kelly, Erica di Martino

Supplementary Table 1. Clinico-pathological characteristics and FGFR3 mutation status of the tumours used for the mRNA study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8afad8ba7ba0a8579220269e6ad7e9
https://doi.org/10.1158/1541-7786.22511124.v1

Molecular profile of pure squamous cell carcinoma of the bladder identifies major roles for OSMR and YAP signalling

Autor: Carolyn D Hurst, Guo Cheng, Fiona M Platt, Olivia Alder, Emma VI Black, Julie E Burns, Joanne Brown, Sunjay Jain, Jo‐An Roulson, Margaret A Knowles

Publikováno v: The Journal of Pathology: Clinical Research. 8:279-293

Pure squamous cell carcinoma (SCC) is the most common pure variant form of bladder cancer, found in 2-5% of cases. It often presents late and is unresponsive to cisplatin-based chemotherapy. The molecular features of these tumours have not been eluci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed7b1496315b19678b0a798b6203691
https://doi.org/10.1002/cjp2.261

Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight

Autor: Carolyn D. Hurst, Guo Cheng, Fiona M. Platt, Mauro A.A. Castro, Nour-al-dain S. Marzouka, Pontus Eriksson, Emma V.I. Black, Olivia Alder, Andrew R.J. Lawson, Sia V. Lindskrog, Julie E. Burns, Sunjay Jain, Jo-An Roulson, Joanne C. Brown, Jan Koster, A. Gordon Robertson, Inigo Martincorena, Lars Dyrskjøt, Mattias Höglund, Margaret A. Knowles

Publikováno v: Cell Reports Medicine
Hurst, C D, Cheng, G, Platt, F M, Castro, M A A, Marzouka, N A D S, Eriksson, P, Black, E V I, Alder, O, Lawson, A R J, Lindskrog, S V, Burns, J E, Jain, S, Roulson, J A, Brown, J C, Koster, J, Robertson, A G, Martincorena, I, Dyrskjøt, L, Höglund, M & Knowles, M A 2021, ' Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight ', Cell Reports Medicine, vol. 2, no. 12, 100472 . https://doi.org/10.1016/j.xcrm.2021.100472
Cell Reports Medicine, 2(12):100472. Cell Press

Summary Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a08008fa4416dc466e726ad6ba197a8
http://www.scopus.com/inward/record.url?scp=85121481080&partnerID=8YFLogxK