Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jörgen Jonsson"'
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionDepression is a major global burden with unclear pathophysiology and poor treatment outcomes. Diagnosis of depression continues to rely primarily on behavioral rather than biological methods. Investigating tools that might aid in diagnosi
Externí odkaz:
https://doaj.org/article/b2818e8dccc04b9e9bc3532e07acfcdc
Autor:
Andrey D. Bondarev, Misty M. Attwood, Jörgen Jonsson, Vladimir N. Chubarev, Vadim V. Tarasov, Wen Liu, Helgi B. Schiöth
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The phosphodiesterase (PDE) enzymes, key regulator of the cyclic nucleotide signal transduction system, are long-established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a particularly h
Externí odkaz:
https://doaj.org/article/a72af28bc4344e818bb63535d3d11b6c
Autor:
Amelia D. Dahlén, Giovanna Dashi, Ivan Maslov, Misty M. Attwood, Jörgen Jonsson, Vladimir Trukhan, Helgi B. Schiöth
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Type 2 diabetes mellitus (T2DM) continues to be a substantial medical problem due to its increasing global prevalence and because chronic hyperglycemic states are closely linked with obesity, liver disease and several cardiovascular diseases. Since t
Externí odkaz:
https://doaj.org/article/af5b91bb11d5434bb911a2c774ac0e2b
Autor:
Diana M. Ciuculete, Sarah Voisin, Lara Kular, Nipuni Welihinda, Jörgen Jonsson, Maja Jagodic, Jessica Mwinyi, Helgi B. Schiöth
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 646-663 (2020)
Unrecognized depression during adolescence can result in adult suicidal behaviour. The aim of this study was to identify, replicate and characterize DNA methylation (DNAm) shifts in depression aetiology, using a longitudinal, multi-tissue (blood and
Externí odkaz:
https://doaj.org/article/5ae3afa8732e4683a3b58bb5064c7252
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4275 (2022)
Many of the survivors of the novel coronavirus disease (COVID-19) are suffering from persistent symptoms, causing significant morbidity and decreasing their quality of life, termed “post-COVID-19 syndrome” or “long COVID”. Understanding the m
Externí odkaz:
https://doaj.org/article/28283532fbc7420884e819c92e269a01
Autor:
Hanna Pettersson, Behdad Zarnegar, Annika Westin, Viktor Persson, Christiane Peuckert, Jörgen Jonsson, Jenny Hallgren, Klas Kullander
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation. St
Externí odkaz:
https://doaj.org/article/741c7a5b20964df38f985281738b71f6
Publikováno v:
Nature Reviews Drug Discovery. 19:695-710
Historically, the main classes of drug targets have been receptors, enzymes, ion channels and transporters. However, owing largely to the rise of antibody-based therapies in the past two decades, soluble protein ligands such as inflammatory cytokines
Autor:
Sarah Voisin, Lara Kular, Nipuni Welihinda, Helgi B. Schiöth, Jessica Mwinyi, Diana M. Ciuculete, Jörgen Jonsson, Maja Jagodic
Publikováno v:
Epigenetics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Unrecognized depression during adolescence can result in adult suicidal behaviour. The aim of this study was to identify, replicate and characterize DNA methylation (DNAm) shifts in depression aetiology, using a longitudinal, multi-tissue (blood and
Autor:
Amelia D, Dahlén, Giovanna, Dashi, Ivan, Maslov, Misty M, Attwood, Jörgen, Jonsson, Vladimir, Trukhan, Helgi B, Schiöth
Publikováno v:
Frontiers in Pharmacology
Type 2 diabetes mellitus (T2DM) continues to be a substantial medical problem due to its increasing global prevalence and because chronic hyperglycemic states are closely linked with obesity, liver disease and several cardiovascular diseases. Since t
Autor:
Kimia Hosseini, Erica C. Forsberg, Sofie V. Hellsten, Jörgen Jonsson, Michael Williams, Helgi Schiöth, Anh-Tri Do, Emilia Lekholm, Robert Fredriksson
Publikováno v:
Toxicon. 214:S25