Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Jörg Huwyler"'
Autor:
Anna Munk, Vanessa Philippi, Verena Buchecker, Marion Bankstahl, Aylina Glasenapp, Andreas Blutke, Effrosyni Michelakaki, Steven Roger Talbot, Jörg Huwyler, Paulin Jirkof, Marcin Kopaczka, Dorit Merhof, Rupert Palme, Heidrun Potschka
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract While neurosurgical interventions are frequently used in laboratory mice, refinement efforts to optimize analgesic management based on multimodal approaches appear to be rather limited. Therefore, we compared the efficacy and tolerability of
Externí odkaz:
https://doaj.org/article/2e35bbed975645f2aa6e47c7be571254
Publikováno v:
SoftwareX, Vol 27, Iss , Pp 101796- (2024)
We present a deep-learning-based software pipeline for reconstructing and segmenting large sets of time-resolved micro-computed tomography (µCT) image data. We construct and train a convolutional neural network (CNN) to consistently, rapidly, and au
Externí odkaz:
https://doaj.org/article/e351302dcc6f4fe29b371879b8425e4e
Publikováno v:
Methods and Protocols, Vol 7, Iss 5, p 68 (2024)
Biological drug substance (DS) is often frozen to enhance storage stability, prolong shelf life, and increase flexibility during manufacturing. However, the freezing and thawing (F/T) of bulk DS at the manufacturing scale can impact product quality a
Externí odkaz:
https://doaj.org/article/1a13ee4e27e0403fb5591d3f6791f186
Autor:
Klervi Golhen, Michael Buettcher, Jörg Huwyler, John van den Anker, Verena Gotta, Kim Dao, Laura E. Rothuizen, Kevin Kobylinski, Marc Pfister
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1186 (2024)
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB
Externí odkaz:
https://doaj.org/article/12e1f1321610492b84aa70d719982c48
Autor:
Samuel Waldner, Erwin Wendelspiess, Pascal Detampel, Christian M. Schlepütz, Jörg Huwyler, Maxim Puchkov
Publikováno v:
Heliyon, Vol 10, Iss 4, Pp e26025- (2024)
The mechanism governing pharmaceutical tablet disintegration is far from fully understood. Despite the importance of controlling a formulation's disintegration process to maximize the active pharmaceutical ingredient's bioavailability and ensure pred
Externí odkaz:
https://doaj.org/article/053037ade64e40188a124f8ed7a23ecb
Autor:
Nancy B Hopf, Laura Suter-Dick, Jörg Huwyler, Myriam Borgatta, Lucie Hegg, David Pamies, Hélène Paschoud, Ramya Deepthi Puligilla, Elena Reale, Sophie Werner, Marie-Gabrielle Zurich
Publikováno v:
JMIR Research Protocols, Vol 13, p e50300 (2024)
BackgroundChemicals are not required to be tested systematically for their neurotoxic potency, although they may contribute to the development of several neurological diseases. The absence of systematic testing may be partially explained by the curre
Externí odkaz:
https://doaj.org/article/6e5ba83bc0d641c6be67270524a82d40
Autor:
João V. C. Batista, Michelle Nonato de Oliveira Melo, Carla Holandino, Jakob Maier, Jörg Huwyler, Stephan Baumgartner, Fabio Boylan
Publikováno v:
Frontiers in Plant Science, Vol 14 (2024)
IntroductionLarch oleoresin has been described regarding several biological activities and medicinal applications, such as wound healing and treatment of ulcers, but little is known about its chemical composition.Material and methodsEight oleoresins
Externí odkaz:
https://doaj.org/article/4306629571054537b5a2ebcb6f32db8d
Autor:
Claudio L. Alter, Pascal Detampel, Roman B. Schefer, Claudia Lotter, Patrick Hauswirth, Ramya D. Puligilla, Vera J. Weibel, Susanne H. Schenk, Wolf Heusermann, Melanie Schürz, Nicole Meisner-Kober, Cornelia Palivan, Tomaž Einfalt, Jörg Huwyler
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Extracellular vesicles (EVs) are highly interesting for the design of next-generation therapeutics. However, their preparation methods face challenges in standardization, yield, and reproducibility. Here, we describe a highly efficient and r
Externí odkaz:
https://doaj.org/article/be10fbb715fc4794919ad22eb4023b74
Autor:
Angelique Wolter, Christian H. Bucher, Sebastian Kurmies, Viktoria Schreiner, Frank Konietschke, Katharina Hohlbaum, Robert Klopfleisch, Max Löhning, Christa Thöne-Reineke, Frank Buttgereit, Jörg Huwyler, Paulin Jirkof, Anna E. Rapp, Annemarie Lang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Adequate pain management is essential for ethical and scientific reasons in animal experiments and should completely cover the period of expected pain without the need for frequent re-application. However, current depot formulations of Bupre
Externí odkaz:
https://doaj.org/article/a3a6e5e452f34a039c52216254fc8390
Autor:
Jan Stephan Bolten, Christine Tanner, Griffin Rodgers, Georg Schulz, Soledad Levano, Timm Weitkamp, Samuel Waldner, Ramya Deepthi Puligilla, Daniel Bodmer, Bert Müller, Jörg Huwyler
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284562 (2023)
Nephrotoxicity is an important drug safety aspect to be assessed during drug discovery and development. To study renal toxicity, in vitro cell-based assays are often used. Unfortunately, translating the results of such cell assays to vertebrates incl
Externí odkaz:
https://doaj.org/article/704316967a424cb0acc9a205ec2a8f5e