Výsledky vyhledávání - "Joëlle Thillet"

Akademický článek

A CYP7A promoter binding factor site and Alu repeat in the distal promoter region are implicated in regulation of human CETP gene expression

Autor: Wilfried Le Goff, Maryse Guerin, M.John Chapman, Joëlle Thillet

Publikováno v: Journal of Lipid Research, Vol 44, Iss 5, Pp 902-910 (2003)

The cholesteryl ester transfer protein (CETP) plays a key role in reverse cholesterol transport in mediating the transfer of cholesteryl ester from HDL to atherogenic apolipoprotein B-containing lipoproteins (VLDL, IDL, and LDL). Variation in plasma

Externí odkaz: https://doaj.org/article/9a2793b4c3be44ab89f0ff09593b9a41

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Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas

Autor: Emmanuelle Crinière, Ivo Gut, Yannick Marie, Joëlle Thillet, Jörg Tost, Florence Busato, Jean-Yves Delattre, Hafida El abdalaoui, Khê Hoang-Xuan, Sibille Everhard, Karima Mokhtari, Florence Laigle-Donadey, Marc Sanson

Publikováno v: Neuro-Oncology. 11:348-356

The O(6)-methylguanine-DNA methyltransferase gene (MGMT) is methylated in several cancers, including gliomas. However, the functional role of cysteine-phosphate-guanine (CpG) island (CGI) methylation in MGMT silencing is still controversial. The aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b952d9a4f64413d04681ff51a88cf9a
https://doi.org/10.1215/15228517-2009-001

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Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri

Autor: Karima Mokhtari, Joëlle Thillet, Y. Marie, François Ducray, Soledad Navarro, Sibille Everhard, Khê Hoang-Xuan, Florence Laigle-Donadey, M. Sanson, J.-Y. Delattre, Gentian Kaloshi, Ahmed Idbaih

Publikováno v: Neurology. 70:590-595

Background: Up-front temozolomide (TMZ) has been recently proposed as a treatment for gliomatosis cerebri (GC), but no predictive or prognostic markers have been identified so far. Because 1p19q codeletion and methylguanine methyl transferase promote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ae21840f09538d3e2fe8e619fce7b4
https://doi.org/10.1212/01.wnl.0000299896.65604.ae

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Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line

Autor: Nathalie Auger, Joëlle Thillet, Marie-Emmanuelle Legrier, Marie-France Poupon, Krystell Wanherdrick, Bernard Dutrillaux, Ahmed Idbaih, Marc Sanson

Publikováno v: Molecular Cancer Therapeutics. 5:2182-2192

Gliomas are highly lethal neoplasms that cannot be cured by currently available therapies. Temozolomide is a recently introduced alkylating agent that has yielded a significant benefit in the treatment of high-grade gliomas. However, either de novo o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d059f44f62b19868cdb63eb16e8c6e59
https://doi.org/10.1158/1535-7163.mct-05-0428

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Prognostic stratification of patients with anaplastic gliomas according to genetic profile

Autor: Marc Sanson, Khe-Hoang Xuan, Marc Polivka, Michèle Kujas, Jean-Yves Delattre, Julie Lejeune, Joëlle Thillet, Marta Pedretti, Yannick Marie, Caroline Dehais, Florence Laigle-Donadey, Alexandra Benouaich-Amiel

Publikováno v: Cancer. 107:1891-1897

BACKGROUND. There is a need to improve the current, controversial, and poorly reproducible classification of anaplastic gliomas, which represent a highly heterogeneous entity in terms of survival. METHODS. The impact of the most common genetic altera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7334e95c4763210d52c13d29afb58c92
https://doi.org/10.1002/cncr.22211

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A CYP7A promoter binding factor site and Alu repeat in the distal promoter region are implicated in regulation of human CETP gene expression

Autor: Joëlle Thillet, Wilfried Le Goff, Maryse Guerin, M. John Chapman

Publikováno v: Journal of Lipid Research, Vol 44, Iss 5, Pp 902-910 (2003)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbf8e8d71509bb9808696eeced9fe4e
http://www.sciencedirect.com/science/article/pii/S0022227520311354

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VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

Autor: Gilles Le Naour, Dragana Milosavljevic, Joëlle Thillet, Anatol Kontush, M. John Chapman, Sabine Griglio

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1631:51-60

Mixed dyslipidemia of phenotype IIB is characterized by elevated levels of very low density lipoprotein (VLDL)-1 and VLDL-2 subfractions and of low density lipoprotein (LDL), which are associated with premature formation of atherosclerotic plaques, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f3575870ee155b4649e7cc09a445bb
https://doi.org/10.1016/s1388-1981(02)00355-4

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Atorvastatin lowers lipoprotein(a) but not apolipoprotein(a) fragment levels in hypercholesterolemic subjects at high cardiovascular risk

Autor: Hervé Laouenan, Andrei C. Sposito, Sophie Gonbert, C. Doucet, M. John Chapman, Sophie Malinsky, Joëlle Thillet

Publikováno v: Atherosclerosis. 164:305-311

The effect of statins on Lp(a) levels is controversial; furthermore, the potential action of statins on apo(a) fragmentation is indeterminate. We therefore determined the circulating levels of Lp(a) and of apo(a) fragments in hypercholesterolemic pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97afdf39711fc7ee7339ec13b3e31842
https://doi.org/10.1016/s0021-9150(02)00072-2

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A novel cholesteryl ester transfer protein promoter polymorphism (−971G/A) associated with plasma high-density lipoprotein cholesterol levels

Autor: Dominique Arveiler, Gérald Luc, Caroline Morrison, M. John Chapman, Maryse Guerin, Viviane Nicaud, Wilfried Le Goff, Frank Kee, Joëlle Thillet, Alun Evans, Jean-Bernard Ruidavets, C. Dachet

Publikováno v: Atherosclerosis. 161:269-279

The plasma cholesteryl ester transfer protein (CETP) plays a key role in reverse cholesterol transport (RCT) by mediating the transfer of cholesteryl ester (CE) from high-density lipoprotein (HDL) to atherogenic ApoB-containing lipoproteins, includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd7b149e87e0509fcdcfe55bdf6a4730
https://doi.org/10.1016/s0021-9150(01)00641-4

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Functional Analysis of the Chimpanzee and Humanapo(a) Promoter Sequences

Autor: Richard M. Lawn, C. Dachet, M. John Chapman, Thierry Huby, Jean Wickings, Joëlle Thillet

Publikováno v: Journal of Biological Chemistry. 276:22209-22214

Lp(a) concentrations vary considerably among individuals and are primarily determined by the apo(a) gene locus. We have previously shown that mean plasma Lp(a) levels in the chimpanzee are significantly higher than those observed in humans (Doucet, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c14eb0efbb535cda86f1abf40f4ae0c8
https://doi.org/10.1074/jbc.m102204200

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