Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joëlle D. Pelletier"'
Autor:
Joëlle D. Pelletier, Donald Poirier
Publikováno v:
Tetrahedron Letters. 35:1051-1054
Boron tribromide was used as a brominating agent for the conversion of alcohols to bromides. Tertiary alcohols were more reactive than secondary alcohols which were more reactive than primary alcohols.
Autor:
Donald Poirier, Joëlle D. Pelletier
Publikováno v:
ChemInform. 25
Boron tribromide was used as a brominating agent for the conversion of alcohols to bromides. Tertiary alcohols were more reactive than secondary alcohols which were more reactive than primary alcohols.
Autor:
Icy D’Silva, Damien D'Amours, Jean Lagueux, Joëlle D. Pelletier, Susan P. Lees-Miller, Michael Weinfeld, M.Ahmad Chaudhry, Guy G. Poirier
Publikováno v:
Biochimica et biophysica acta. 1430(1)
Poly(ADP-ribose) polymerase (PARP) and DNA-dependent protein kinase (DNA-PK) are important nuclear enzymes that cooperate to minimize genomic damage caused by DNA strand interruptions. DNA strand interruptions trigger the ADP-ribosylation activity an
Autor:
Joëlle D. Pelletier, Donald Poirier
Publikováno v:
Bioorganicmedicinal chemistry. 4(10)
To develop inhibitors of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) without residual estrogenic activity, the synthesis of 16 alpha-(bromoalkylamide) derivatives of estradiol was performed starting from a key intermediate aldehyde obtained fr
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 52(6)
The catalyzed coupling reaction of activated alcohol and mercaptan was used for the short and efficient synthesis of 14 thioether compounds. Two types of side chains, the methyl butyl alkylamide related to the pure steroidal antiestrogen ICI 164384 a
Publikováno v:
Steroids. 59(9)
The synthesis of a 16 alpha-(bromoalkylamide) derivative of estradiol (N-butyl, N-methyl, 11-[3',17' beta-(dihydroxy)-1',3',5' (10')-estratrien-16' alpha-yl]-9(R/S)-bromo undecanamide) was performed by two different approaches starting from estrone.
Autor:
Michael Weinfeld, M. Ahmad Chaudhry, Damien D'Amours, Joëlle D. Pelletier, Guy G. Poirier, Lawrence F. Povirk, Susan P. Lees-Miller, Joelle D. Pelletier
Publikováno v:
Radiation Research. 148:22
Two of the enzymes involved in the response of mammalian cells to ionizing radiation are the DNA-dependent protein kinase and poly(ADP-ribose) polymerase. These enzymes are known to be activated by binding to DNA strand breaks, but previous studies d