Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Joël Rousseau"'
Autor:
Eli BenDavid, Sina Ramezanian, Yaoyao Lu, Joël Rousseau, Avi Schroeder, Marc Lavertu, Jacques P. Tremblay
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 763 (2024)
Prime editing shows potential as a precision genome editing technology, as well as the potential to advance the development of next-generation nanomedicine for addressing neurological disorders. However, turning in prime editors (PEs), which are macr
Externí odkaz:
https://doaj.org/article/09d0d33510234dd399a4bb216167add3
Publikováno v:
Cells, Vol 13, Iss 1, p 31 (2023)
We report the first correction from prime editing a mutation in the RYR1 gene, paving the way to gene therapies for RYR1-related myopathies. The RYR1 gene codes for a calcium channel named Ryanodine receptor 1, which is expressed in skeletal muscle f
Externí odkaz:
https://doaj.org/article/91aef639e2f445d0bd1581be4b1b97ad
Autor:
Antoine Guyon, Joël Rousseau, Francis-Gabriel Bégin, Tom Bertin, Gabriel Lamothe, Jacques P. Tremblay
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 253-263 (2021)
The amyloid precursor protein (APP) is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which leads to Alzheimer’s disease. Genomic analysis of a
Externí odkaz:
https://doaj.org/article/8bc966a60c2f4ebe970f012eeb2aab52
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0237122 (2020)
The deposition of Aβ plaques in the brain leads to the onset and development of Alzheimer's disease. The Amyloid precursor protein (APP) is cleaved by α-secretase (non-amyloidogenic processing of APP), however increased cleavage by β-secretase (BA
Externí odkaz:
https://doaj.org/article/8755a4938da64739b680b6e8e08bda41
Autor:
Khadija Cherif, Catherine Gérard, Joël Rousseau, Dominique L. Ouellet, Pierre Chapdelaine, Jacques P. Tremblay
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 19-32 (2018)
Frataxin gene (FXN) expression is reduced in Friedreich’s ataxia patients due to an increase in the number of GAA trinucleotides in intron 1. The frataxin protein, encoded by that gene, plays an important role in mitochondria’s iron metabolism. P
Externí odkaz:
https://doaj.org/article/c662c1a1cd654951aada49fc008f552b
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 68-79 (2017)
Laminin-111 protein complex links the extracellular matrix to integrin α7β1 in sarcolemma, thus replacing in dystrophic muscles links normally insured by the dystrophin complex. Laminin-111 injection in mdx mouse stabilized sarcolemma, restored ser
Externí odkaz:
https://doaj.org/article/e9b6e04a8b17453eb62498f5649b5914
Autor:
Jean-Paul Iyombe-Engembe, Dominique L Ouellet, Xavier Barbeau, Joël Rousseau, Pierre Chapdelaine, Patrick Lagüe, Jacques P Tremblay
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The CRISPR/Cas9 system is a great revolution in biology. This technology allows the modification of genes in vitro and in vivo in a wide variety of living organisms. In most Duchenne muscular dystrophy (DMD) patients, expression of dystrophin (DYS) p
Externí odkaz:
https://doaj.org/article/a9147231a34740ca8f85610fbfe3a9c1
Autor:
Aurélie Fuentes-Rodriguez, Andrew Mitchell, Joël Rousseau, Jacques P. Tremblay, Solange Landreville
Publikováno v:
Cancer Research. 83:2610-2610
Uveal melanoma (UM) is the most frequent intraocular cancer in adults and 50% of patients develop liver metastases for which no treatment is effective. According to The Cancer Genome Atlas, 92% of cases are characterized by early mutations in two gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994e3cae2597690680983d9b40468e63
https://doi.org/10.1158/1538-7445.am2023-2610
https://doi.org/10.1158/1538-7445.am2023-2610
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6160
The Prime editing technique derived from the CRISPR/Cas9 discovery permits the modification of selected nucleotides in a specific gene. We used it to insert specific point mutations in exons 9, 20, 35, 43, 55 and 61 of the Duchenne Muscular Dystrophy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e4b54ad2a09a6a23843e6c3971187a
https://pubmed.ncbi.nlm.nih.gov/35682838
https://pubmed.ncbi.nlm.nih.gov/35682838
Autor:
Nathalie Majeau, Annabelle Fortin-Archambault, Catherine Gérard, Joël Rousseau, Pouiré Yaméogo, Jacques P. Tremblay
Publikováno v:
Mol Ther
Extracellular vesicles (EVs) mediate intercellular biomolecule exchanges in the body, making them promising delivery vehicles for therapeutic cargo. Genetic engineering by the CRISPR system is an interesting therapeutic avenue for genetic diseases su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b432d3b6c3300e46e3d27a9f5ffbedc5
https://pubmed.ncbi.nlm.nih.gov/35619556
https://pubmed.ncbi.nlm.nih.gov/35619556