Zobrazeno 1 - 10
of 10
pro vyhledávání: '"João de Sousa Valente"'
Autor:
Ali A. Zarban, Hiba Chaudhry, João de Sousa Valente, Fulye Argunhan, Hala Ghanim, Susan D. Brain
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12246 (2022)
Oedema formation and polymorphonuclear leukocyte (neutrophil) accumulation are involved in both acute and chronic inflammation. Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide that is released from stimulated sensory nerves. CGRP is
Externí odkaz:
https://doaj.org/article/2b9816f77fc04074b06306e0c1177716
Autor:
João de Sousa Valente, Khadija M. Alawi, Patrik Keringer, Sabah Bharde, Faseeha Ayaz, Nurjahan Saleque, Xenia Kodji, Dibesh Thapa, Fulye Argunhan, Susan D. Brain
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 2, Iss 4, Pp 100119- (2020)
Introduction: Osteo-arthritis (OA) involves joint degradation and usually pain; with mechanisms poorly understood and few treatment options. There is evidence that the transient receptor potential canonical 5 (TRPC5) mRNA expression is reduced in OA
Externí odkaz:
https://doaj.org/article/2c54f1ea129e4e75adabb9d90137596c
Autor:
Liziane Cristine Malaquias da Silva, Fernanda da Silva Platner, Lauany da Silva Fonseca, Virgílio Frota Rossato, Dian Carlos Pereira de Andrade, João de Sousa Valente, Susan Diana Brain, Elizabeth Soares Fernandes
Publikováno v:
Pathogens, Vol 11, Iss 4, p 412 (2022)
The Chikungunya virus (CHIKV) can cause long lasting symptoms and manifestations. However, there is little information on which ocular ones are most frequent following infection. We performed a systematic review (registered in the International Prosp
Externí odkaz:
https://doaj.org/article/48ce5f4cb09d4f08aea6aa84d3264ad1
Autor:
João de Sousa Valente, Khadija M Alawi, Sabah Bharde, Ali A. Zarban, Xenia Kodji, Dibesh Thapa, Fulye Argunhan, Brentton Barrett, Istvan Nagy, Susan D. Brain
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6380 (2021)
Recently, we found that the deletion of TRPC5 leads to increased inflammation and pain-related behaviour in two animal models of arthritis. (-)-Englerin A (EA), an extract from the East African plant Phyllanthus engleri has been identified as a TRPC4
Externí odkaz:
https://doaj.org/article/9d944d41a60d46cb990f6209990cfee9
Autor:
João de Sousa Valente
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The high incidence of osteoarthritis (OA) in an increasingly elderly population anticipates a dramatic rise in the number of people suffering from this disease in the near future. Because pain is the main reason patients seek medical help, effective
Externí odkaz:
https://doaj.org/article/83017abf69224efaa71cfecacbd93f35
Autor:
Tiago Dantas, Carla M. C. Abreu, Maria J. G. De-Castro, Ana Rita Grosso, Joao de Sousa Valente, Gabriela da Silva Xavier
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/3d067a36984545c7bcbfd2ca49f46a08
Autor:
Ali A. Zarban, Hiba Chaudhry, Davide Maselli, Xenia Kodji, Joao de Sousa Valente, Justin Joachim, Silvia Cellone Trevelin, Johannes van Baardewijk, Fulye Argunhan, Aleksandar Ivetic, Manasi Nandi, Susan D. Brain
Publikováno v:
JID Innovations, Vol 3, Iss 1, Pp 100154- (2023)
Inflammatory edema formation and polymorphonuclear leukocyte (neutrophil) accumulation are common components of cutaneous vascular inflammation, and their assessment is a powerful investigative and drug development tool but typically requires indepen
Externí odkaz:
https://doaj.org/article/59df44f293d64433a13aa30d1e98a354
Autor:
Tianci Li, Gaoge Wang, Vivian Chin Chin Hui, Daniel Saad, Joao de Sousa Valente, Paolo La Montanara, Istvan Nagy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Increased activity and excitability (sensitisation) of a series of molecules including the transient receptor potential ion channel, vanilloid subfamily, member 1 (TRPV1) in pain-sensing (nociceptive) primary sensory neurons are pivotal for
Externí odkaz:
https://doaj.org/article/0e8c624f13d84d4995ac9e642247fd89
Autor:
Dibesh Thapa, Joäo de Sousa Valente, Brentton Barrett, Matthew John Smith, Fulye Argunhan, Sheng Y Lee, Sofya Nikitochkina, Xenia Kodji, Susan D Brain
Publikováno v:
eLife, Vol 10 (2021)
Ageing is associated with increased vulnerability to environmental cold exposure. Previously, we identified the role of the cold-sensitive transient receptor potential (TRP) A1, M8 receptors as vascular cold sensors in mouse skin. We hypothesised tha
Externí odkaz:
https://doaj.org/article/26ce2891ff7b4b918ed2630701c56e1e
Autor:
Xenia Kodji, Zizheng Kee, Robyn McKenna, Joao de Sousa Valente, Harriet Ravenscroft, Hayley McMillan, John Gamble, Yvonne Dombrowski, Paul Moynagh, David Brough, Fionnuala T. Lundy, Susan D. Brain, Ikhlas A. El Karim
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1073 (2021)
This study investigates the role of transient receptor potential ankyrin 1 (TRPA1) in murine temporomandibular joint (TMJ) inflammatory hyperalgesia and the influence of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome. Two distinct muri
Externí odkaz:
https://doaj.org/article/26fbdb45b27d4d6c906fb94d82b206c3