Reverse Engineering of the Pediatric Sepsis Regulatory Network and Identification of Master Regulators

Autor: Raffael Azevedo de Carvalho Oliveira, Danilo Oliveira Imparato, Vítor Gabriel Saldanha Fernandes, João Vitor Ferreira Cavalcante, Ricardo D’Oliveira Albanus, Rodrigo Juliani Siqueira Dalmolin

Publikováno v: Biomedicines, Vol 9, Iss 10, p 1297 (2021)

Sepsis remains a leading cause of death in ICUs all over the world, with pediatric sepsis accounting for a high percentage of mortality in pediatric ICUs. Its complexity makes it difficult to establish a consensus on genetic biomarkers and therapeuti

Externí odkaz: https://doaj.org/article/b1f3ba11070e44b6b7e051ab10212e7b

Ancestry analysis indicates two different sets of essential genes in eukaryotic model species

Autor: Vítor Gabriel Saldanha Fernandes, Rodrigo Juliani Siqueira Dalmolin, João Vitor Ferreira Cavalcante, Iara Dantas de Souza, Diego A. A. Morais, Clovis Ferreira Dos Reis

Publikováno v: Functional & Integrative Genomics. 21:523-531

Essential genes are so-called because they are crucial for organism perpetuation. Those genes are usually related to essential functions to cellular metabolism or multicellular homeostasis. Deleterious alterations on essential genes produce a spectru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::038caee1c53eb5564d9fa6424166ae3b
https://doi.org/10.1007/s10142-021-00794-9

Complex Portal 2022: new curation frontiers

Autor: Anjali Shrivastava, Noemi del-Toro, Tiago Lubiana, Pablo Porras, Andra Waagmeester, Elisabeth Barrera, Egon Willighagen, Sandra Orchard, Bernhard Mlecnik, Juri Rappsilber, Birgit H M Meldal, João Vitor Ferreira Cavalcante, Kalpana Panneerselvam, Gabriela Bindea, Livia Perfetto, Henning Hermjakob, Colin W. Combe, Edith D. Wong, Hema Bye-A-Jee

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, In press, ⟨10.1093/nar/gkab991⟩
Nucleic Acids Research, 50(D1), D578-D586. Oxford University Press
Meldal, B H M, Perfetto, L, Combe, C, Lubiana, T, Cavalcante, J V F, Bye-A-Jee, H, Waagmeester, A, del-Toro, N, Shrivastava, A, Barrera, E, Wong, E, Mlecnik, B, Bindea, G, Panneerselvam, K, Willighagen, E, Rappsilber, J, Porras, P, Hermjakob, H & Orchard, S 2021, ' Complex Portal 2022 : New curation frontiers ', Nucleic Acids Research, vol. 50, no. D1, pp. D578-D586 . https://doi.org/10.1093/nar/gkab991

The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated, encyclopaedic database of macromolecular complexes with known function from a range of model organisms. It summarizes complex composition, topology and function along with links

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b9dff31ee0f84c010761cc808caebb
https://hal.sorbonne-universite.fr/hal-03421220/file/gkab991.pdf