Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model

Autor: Marzia Malcangio, Raffaele Simeoli, L. Calvo, V. Vacca, João Sousa-Valente, Juan Carlos Arévalo

Publikováno v: Osteoarthritis and cartilage 26 (2017): 84–94. doi:10.1016/j.joca.2017.08.006
info:cnr-pdr/source/autori:J. Sousa-Valente y, L. Calvo z x, V. Vacca y k, R. Simeoli y, J.C. Arevalo z x, M. Malcangio y/titolo:Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model./doi:10.1016%2Fj.joca.2017.08.006/rivista:Osteoarthritis and cartilage/anno:2017/pagina_da:84/pagina_a:94/intervallo_pagine:84–94/volume:26
De Sousa Valente, J, Calvo, L, Vacca, V, Simeoli, R, Arévalo, J C & Malcangio, M 2017, ' Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model ', Osteoarthritis and Cartilage . https://doi.org/10.1016/j.joca.2017.08.006, https://doi.org/10.1016/j.joca.2017.08.006

Summary Objective Aiming to delineate novel neuro-immune mechanisms for NGF/TrkA signalling in osteoarthritis (OA) pain, we evaluated inflammatory changes in the knee joints following injection of monoiodoacetate (MIA) in mice carrying a TrkA recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56bb4830adb31a1eadf50e45a4744bb
https://doi.org/10.1016/j.joca.2017.08.006

Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics

Autor: Laszlo Urban, João Sousa-Valente, István Nagy, Anna P. Andreou

Publikováno v: British Journal of Pharmacology. 171:2508-2527

The last decade has witnessed an explosion in novel findings relating to the molecules involved in mediating the sensation of pain in humans. Transient receptor potential (TRP) ion channels emerged as the greatest group of molecules involved in the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52b23b0fd4c6881d36ceb94b9cf3d302
https://doi.org/10.1111/bph.12532

Anandamide produced by Ca2+-insensitive enzymes induces excitation in primary sensory neurons

Autor: Vincenzo Di Marzo, László Csernoch, Laki Buluwela, Srikumaran Selvarajah, Agnes Jenes, István Nagy, Fabiana Piscitelli, Fiona Kyle, Anthony H. Taylor, Jonothan Austin, Timothy H. Marczylo, Jie Chen, Anna P. Andreou, John P. M. White, João Sousa-Valente, Susan D. Brain, Mohammed Yaqoob, Angelika Varga

Publikováno v: Pflügers Archiv 466 (2014): 1421–1435. doi:10.1007/s00424-013-1360-7
info:cnr-pdr/source/autori:Varga, Angelika; Jenes, Agnes; Marczylo, Timothy H.; Sousa-Valente, Joao; Chen, Jie; Austin, Jonothan; Selvarajah, Srikumaran; Piscitelli, Fabiana; Andreou, Anna P.; Taylor, Anthony H.; Kyle, Fiona; Yaqoob, Mohammed; Brain, Sue; White, John P. M.; Csernoch, Laszlo; Di Marzo, Vincenzo; Buluwela, Laki; Nagy, Istvan/titolo:Anandamide produced by Ca2+-insensitive enzymes induces excitation in primary sensory neurons/doi:10.1007%2Fs00424-013-1360-7/rivista:Pflügers Archiv/anno:2014/pagina_da:1421/pagina_a:1435/intervallo_pagine:1421–1435/volume:466

The endogenous lipid agent N-arachidonoylethanolamine (anandamide), among other effects, has been shown to be involved in nociceptive processing both in the central and peripheral nervous systems. Anandamide is thought to be synthesised by several en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b477d0bf239132376434e5aa78ba7a9
http://hdl.handle.net/10044/1/19606

Anandamide in primary sensory neurons: too much of a good thing?

Autor: Ankur Khajuria, Angelika Varga, István Nagy, João Sousa-Valente, Kajaluxy Ananthan

The quest for possible targets for the development of novel analgesics has identified the activation of the cannabinoid type 1 (CB1) receptor outside the CNS as a potential means of providing relief from persistent pain, which currently constitutes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c37eba9d5375351d7bbf8811cf44120