Zobrazeno 1 - 10
of 55
pro vyhledávání: '"João S, Silva"'
Autor:
Luciana Benevides, Lais A. Sacramento, Franciele Pioto, Gabriel Dessotti Barretto, Vanessa Carregaro, João S. Silva
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In many infectious diseases, the pathogen-induced inflammatory response could result in protective immunity that should be regulated to prevent tissue damage and death. In fact, in Trypanosoma cruzi infection, the innate immune and the inflammatory r
Externí odkaz:
https://doaj.org/article/9f12902d63294486bf5e69e6b896d2f8
Autor:
Patrick O. Azevedo, Natália S. Hojo-Souza, Lídia P. Faustino, Marcílio J. Fumagalli, Isabella C. Hirako, Emiliano R. Oliveira, Maria M. Figueiredo, Alex F. Carvalho, Daniel Doro, Luciana Benevides, Edison Durigon, Flávio Fonseca, Alexandre M. Machado, Ana P. Fernandes, Santuza R. Teixeira, João S. Silva, Ricardo T. Gazzinelli
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract The current COVID-19 vaccines protect against severe disease, but are not effective in controlling replication of the Variants of Concern (VOCs). Here, we used the existing pre-clinical models of severe and moderate COVID-19 to evaluate the
Externí odkaz:
https://doaj.org/article/4a8c5ff3ae614acda13990e86c59621f
Autor:
Julia T. Castro, Patrick Azevedo, Marcílio J. Fumagalli, Natalia S. Hojo-Souza, Natalia Salazar, Gregório G. Almeida, Livia I. Oliveira, Lídia Faustino, Lis R. Antonelli, Tomas G. Marçal, Marconi Augusto, Bruno Valiate, Alex Fiorini, Bruna Rattis, Simone G. Ramos, Mariela Piccin, Osvaldo Campos Nonato, Luciana Benevides, Rubens Magalhães, Bruno Cassaro, Gabriela Burle, Daniel Doro, Jorge Kalil, Edson Durigon, Andrés Salazar, Otávia Caballero, Helton Santiago, Alexandre Machado, João S. Silva, Flávio da Fonseca, Ana Paula Fernandes, Santuza R. Teixeira, Ricardo T. Gazzinelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Protection against SARS-CoV-2 infection involves T cell and B cell responses but only studying one or the other has proved difficult. Here the authors immunise with a fusion protein construct of N and RBD proteins from SARS-CoV-2 and find that this p
Externí odkaz:
https://doaj.org/article/fbd032f9247b44c182fc808ade479c51
Autor:
Juliana C. Costa-Madeira, Gabrielly B. Trindade, Paulo H. P. Almeida, João S. Silva, Vanessa Carregaro
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A key point of immunity against protozoan Leishmania parasites is the development of an optimal T cell response, which includes a low apoptotic rate, high proliferative activity and polyfunctionality. During acute infection, antigen-specific T cells
Externí odkaz:
https://doaj.org/article/d8b721669d124622be87167f6fe0a9d0
Autor:
João S Silva
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 117 (2022)
Externí odkaz:
https://doaj.org/article/9895a82fb23544b2afbc97b25d9627f4
Autor:
Sandra R. Maruyama, Alynne K.M. de Santana, Nayore T. Takamiya, Talita Y. Takahashi, Luana A. Rogerio, Caio A.B. Oliveira, Cristiane M. Milanezi, Viviane A. Trombela, Angela K. Cruz, Amélia R. Jesus, Aline S. Barreto, Angela M. da Silva, Roque P. Almeida, José M. Ribeiro, João S. Silva
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 11, Pp 2088-2092 (2019)
Through whole-genome sequencing analysis, we identified non-Leishmania parasites isolated from a man with a fatal visceral leishmaniasis–like illness in Brazil. The parasites infected mice and reproduced the patient’s clinical manifestations. Mol
Externí odkaz:
https://doaj.org/article/edce138ad377404ebf2f031fe89535c1
Autor:
Camila O.S. Souza, Natália Ketelut-Carneiro, Cristiane M. Milanezi, Lúcia H. Faccioli, Luiz G. Gardinassi, João S. Silva
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102548- (2021)
Summary: The recognition of fungi by intracellular NOD-like receptors (NLRs) induces inflammasome assembly and activation. Although the NLRC4 inflammasome has been extensively studied in bacterial infections, its role during fungal infections is uncl
Externí odkaz:
https://doaj.org/article/8c953e87d780462f8f6d2c8bb1180761
Autor:
Daniela Carlos, Malena M. Pérez, Jefferson A. Leite, Fernanda A. Rocha, Larissa M. S. Martins, Camila A. Pereira, Thais F. C. Fraga-Silva, Taís A. Pucci, Simone G. Ramos, Niels O. S. Câmara, Vânia L. D. Bonato, Rita C. Tostes, João S. Silva
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Type 2 diabetes (T2D) is a metabolic disease characterized by increased inflammation, NOD-like receptors (NLRs) activation and gut dysbiosis. Our research group has recently reported that intestinal Th17 response limits gut dysbiosis and LPS transloc
Externí odkaz:
https://doaj.org/article/7705bc6bfb7d40c59deeeeedc0a47ec1
Autor:
Camila A. Pereira, Daniela Carlos, Nathanne S. Ferreira, Josiane F. Silva, Camila Z. Zanotto, Dario S. Zamboni, Valéria D. Garcia, Dora Fix Ventura, João S. Silva, Rita C. Tostes
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Background: NLRP3 inflammasome activation in response to several signals, including mitochondrial DNA (mDNA), regulates inflammatory responses by caspase-1 activation and interleukin-1β (IL-1β) release. Circulating mDNA is linked to micro and macro
Externí odkaz:
https://doaj.org/article/7065ecb181e44981971a701eec1b73d7
Autor:
Maria C. Silva, Marcela Davoli-Ferreira, Tiago S. Medina, Renata Sesti-Costa, Grace K. Silva, Carla D. Lopes, Lucas E. Cardozo, Fábio N. Gava, Konstantina Lyroni, Fabrício C. Dias, Amanda F. Frade, Monique Baron, Helder I. Nakaya, Florêncio Figueiredo, José C. Alves-Filho, Fernando Q. Cunha, Christos Tsatsanis, Christophe Chevillard, Edecio Cunha-Neto, Emilio Hirsch, João S. Silva, Thiago M. Cunha
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression corre
Externí odkaz:
https://doaj.org/article/ed3bd260c7f349aaacab38a75bacfe6c