Zobrazeno 1 - 10 of 12 pro vyhledávání: '"João R. Lima-Júnior"'
1
Akademický článek
Autologous hematopoietic stem cell transplantation promotes connective tissue remodeling in systemic sclerosis patients
Autor: Djúlio C. Zanin-Silva, Maynara Santana-Gonçalves, Marianna Y. Kawashima-Vasconcelos, João R. Lima-Júnior, Juliana B. E. Dias, Daniela A. Moraes, Dimas T. Covas, Kelen C. R. Malmegrim, Leandra Ramalho, Maria Carolina Oliveira
Publikováno v: Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background Autologous hematopoietic stem cell transplantation (AHSCT) treats patients with severe and progressive systemic sclerosis (SSc). However, basic mechanisms associated with the therapeutic efficacy of the procedure are not entirely
Externí odkaz: https://doaj.org/article/b2f7855cf24c4e3fbc3e771ba12a5318
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2
Akademický článek
Autologous hematopoietic stem cell transplantation modifies specific aspects of systemic sclerosis-related microvasculopathy
Autor: Maynara Santana-Gonçalves, Djúlio Zanin-Silva, Álvaro Henrique-Neto, Daniela A. Moraes, Marianna Y. Kawashima- Vasconcelos, João R. Lima-Júnior, Juliana B. E. Dias, Vinícius Bragagnollo, Júlia T. C. de Azevedo, Dimas T. Covas, Kelen C. R. Malmegrim, Leandra Ramalho, Maria Carolina Oliveira
Publikováno v: Therapeutic Advances in Musculoskeletal Disease, Vol 14 (2022)
Objective: Autologous hematopoietic stem cell transplantation (AHSCT) is a therapeutic option for patients with severe and progressive systemic sclerosis (SSc). Here, we aimed to investigate how AHSCT affects the vasculopathy of SSc patients. Methods
Externí odkaz: https://doaj.org/article/fe689f9799d147c78acb120702099a53
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3
Akademický článek
Immune rebound associates with a favorable clinical response to autologous HSCT in systemic sclerosis patients
Autor: Lucas C.M. Arruda, Kelen C.R. Malmegrim, João R. Lima-Júnior, Emmanuel Clave, Juliana B.E. Dias, Daniela A. Moraes, Corinne Douay, Isabelle Fournier, Hélène Moins-Teisserenc, Antônio José Alberdi, Dimas T. Covas, Belinda P. Simões, Pauline Lansiaux, Antoine Toubert, Maria Carolina Oliveira
Publikováno v: Blood Advances, Vol 2, Iss 2, Pp 126-141 (2018)
Abstract: To evaluate the immunological mechanisms associated with clinical outcomes after autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T- (Treg) and B- (Breg) cell immune reconstitution, 31 systemic sclerosis (S
Externí odkaz: https://doaj.org/article/9767335330294441b6144d475820254c
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4
Autologous hematopoietic stem cell transplantation modifies specific aspects of systemic sclerosis-related microvasculopathy
Autor: Maynara Santana-Gonçalves, Djúlio Zanin-Silva, Álvaro Henrique-Neto, Daniela A. Moraes, Marianna Y. Kawashima- Vasconcelos, João R. Lima-Júnior, Juliana B. E. Dias, Vinícius Bragagnollo, Júlia T. C. de Azevedo, Dimas T. Covas, Kelen C. R. Malmegrim, Leandra Ramalho, Maria Carolina Oliveira
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Objective: Autologous hematopoietic stem cell transplantation (AHSCT) is a therapeutic option for patients with severe and progressive systemic sclerosis (SSc). Here, we aimed to investigate how AHSCT affects the vasculopathy of SSc patients. Methods
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb9a7633bb3ed0ceed68738ca8817bb
https://pubmed.ncbi.nlm.nih.gov/35368373
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5
Autologous hematopoietic stem cell transplantation restores the suppressive capacity of regulatory B cells in systemic sclerosis patients
Autor: Kelen C. R. Malmegrim, Dimas Tadeu Covas, Lucas C. M. Arruda, João R Lima-Júnior, Maynara Santana Gonçalves, Daniela A. Moraes, Juliana Bernardes Elias Dias, Belinda Pinto Simões, Maria Carolina Oliveira
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Objectives The rationale of autologous haematopoietic stem cell transplantation (AHSCT) for autoimmune diseases is that high-dose immunosuppression eradicates autoreactive T and B cells and the infused autologous haematopoietic stem cells promote rec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f6227700088f8db0f65370860fe50a
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7
Immune rebound associates with a favorable clinical response to autologous HSCT in systemic sclerosis patients
Autor: Emmanuel Clave, Kelen C. R. Malmegrim, Hélène Moins-Teisserenc, Corinne Douay, Dimas Tadeu Covas, Antonio José Alberdi, Belinda Pinto Simões, Pauline Lansiaux, Maria Carolina Oliveira, Isabelle Fournier, Antoine Toubert, Lucas C. M. Arruda, João R Lima-Júnior, Juliana Bernardes Elias Dias, Daniela A. Moraes
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
To evaluate the immunological mechanisms associated with clinical outcomes after autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T- (Treg) and B- (Breg) cell immune reconstitution, 31 systemic sclerosis (SSc) patien
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f4adce2def08df1f07456b70b3d8ee
https://doi.org/10.1182/bloodadvances.2017011072
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8
Thymus Rejuvenation After Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases
Autor: Lucas C. M. Arruda, João R Lima-Júnior, Kelen C. R. Malmegrim, Maria Carolina de Oliveira
Publikováno v: Thymus Transcriptome and Cell Biology ISBN: 9783030120399
Autologous hematopoietic stem cell transplantation (AHSCT) has been established as an important therapeutic approach for patients with autoimmune diseases (AD) refractory to conventional treatment. This therapy is able to promote long-term remission
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::485669fa26cd24580132bb360277b72f
https://doi.org/10.1007/978-3-030-12040-5_14
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9
Homeostatic proliferation leads to telomere attrition and increased PD-1 expression after autologous hematopoietic SCT for systemic sclerosis
Autor: Hélène Moins-Teisserenc, Maria Carolina Oliveira, Corinne Douay, Lucas C. M. Arruda, Dimas Tadeu Covas, Daniela A. Moraes, Emmanuel Clave, João R Lima-Júnior, Kelen C. R. Malmegrim, Isabelle Fournier, Dominique Farge, Belinda Pinto Simões, Antoine Toubert
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
In the months that follow autologous hematopoietic stem cell transplantation (AHSCT), lymphopenia drives homeostatic proliferation, leading to oligoclonal expansion of residual cells. Here we evaluated how replicative senescent and exhausted cells as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa57df19c405e080da9bbfec3559cff
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10
Homeostatic proliferation leads to telomere attrition and increased PD-1 expression after autologous hematopoietic SCT for systemic sclerosis
Autor: Lucas C M, Arruda, João R, Lima-Júnior, Emmanuel, Clave, Daniela A, Moraes, Corinne, Douay, Isabelle, Fournier, Hélène, Moins-Teisserenc, Dimas T, Covas, Belinda P, Simões, Dominique, Farge, Antoine, Toubert, Kelen C R, Malmegrim, Maria Carolina, Oliveira
Publikováno v: Bone marrow transplantation. 53(10)
In the months that follow autologous hematopoietic stem cell transplantation (AHSCT), lymphopenia drives homeostatic proliferation, leading to oligoclonal expansion of residual cells. Here we evaluated how replicative senescent and exhausted cells as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8aed99abe8d6bb4e1886f87d27a38ab3
https://pubmed.ncbi.nlm.nih.gov/29670207
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