Výsledky vyhledávání - "João R M Marchante"

Akademický článek

Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Autor: Roel Polak, Marc B. Bierings, Cindy S. van der Leije, Mathijs A. Sanders, Onno Roovers, João R. M. Marchante, Judith M. Boer, Jan J. Cornelissen, Rob Pieters, Monique L. den Boer, Miranda Buitenhuis

Publikováno v: Haematologica, Vol 104, Iss 4 (2019)

Translocation t(12;21), resulting in the ETV6-RUNX1 (or TEL-AML1) fusion protein, is present in 25% of pediatric patients with B-cell precursor acute lymphoblastic leukemia and is considered a first hit in leukemogenesis. A targeted therapy approach

Externí odkaz: https://doaj.org/article/4bd5df9ab18c4a7ea4cc4a5921e64071

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Akademický článek

BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures

Autor: Judith M. Boer, João R. M. Marchante, William E. Evans, Martin A. Horstmann, Gabriele Escherich, Rob Pieters, Monique L. Den Boer

Publikováno v: Haematologica, Vol 100, Iss 9 (2015)

Externí odkaz: https://doaj.org/article/deb15236817e43b1b0a917bf2930ebbf

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Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Autor: Mathijs A. Sanders, Onno Roovers, Jan J. Cornelissen, Marc Bierings, Rob Pieters, Roel Polak, Cindy S. van der Leije, Judith M. Boer, Monique L. den Boer, Miranda Buitenhuis, João R. M. Marchante

Publikováno v: Haematologica, 104(4), 738. Ferrata Storti Foundation
Haematologica
Haematologica, 104(4), 738-748. Ferrata Storti Foundation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bce5c4b68e4dc30339434e7cd423ed
https://doi.org/10.3324/haematol.2018.193631

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Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia

Autor: Elisabeth M. P. Steeghs, C. Ellen van der Schoot, Judith M. Boer, Monique L. den Boer, H. Berna Beverloo, Vincent H.J. van der Velden, Rob Pieters, Gabriele Escherich, Aurélie Boeree, James J. Beaudoin, Roland P. Kuiper, Hester A. de Groot-Kruseman, João R M Marchante

Publikováno v: Oncotarget, 8, 3, pp. 4618-4628
Oncotarget, 8, 4618-4628
Oncotarget, 8(3), 4618-4628. Impact Journals
Oncotarget, 8(3), 4618-4628. Impact Journals LLC
Oncotarget

Contains fulltext : 169868.pdf (Publisher’s version ) (Open Access) Approximately 15% of pediatric B cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by gene expression similar to that of BCR-ABL1-positive disease and unfavora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64264704fadf6463f391cf50c551a386
https://doi.org/10.18632/oncotarget.13492

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The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia

Autor: Klaus Fortschegger, Sabine Strehl, Maximilian Kauer, Reinhard Kofler, Dagmar Schinnerl, João R. M. Marchante, Monique L. den Boer

Publikováno v: Blood, 125(8), 1282-1291. American Society of Hematology

PAX5-JAK2 has recently been identified as a novel recurrent fusion gene in B-cell precursor acute lymphoblastic leukemia, but the function of the encoded chimeric protein has not yet been characterized in detail. Herein we show that the PAX5-JAK2 chi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e78cb4e84305c3460dd72fc92a70257
https://europepmc.org/articles/PMC4375719/

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BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures

Autor: Rob Pieters, Gabriele Escherich, William E. Evans, Monique L. den Boer, Judith M. Boer, João R. M. Marchante, Martin A. Horstmann

Publikováno v: Haematologica, 100, e354-e357. Ferrata Storti Foundation

Patients with pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with the BCR-ABL1 fusion gene form a small, high-risk group with a poor prognosis.[1][1] Approximately 15% of cases of BCP-ALL are characterized by a gene expression sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0386b347185282387496f1dbaa44af86
https://pure.eur.nl/en/publications/237acc52-32c3-4e98-89c9-494845c9093a

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MicroRNA signature in BCR-ABL1-like and BCR-ABL1-positive childhood acute lymphoblastic leukemia: similarities and dissimilarities

Autor: Farhad Akbari Moqadam, João R. M. Marchante, Judith M. Boer, Monique L. den Boer, Arian van der Veer, Ellen Lange-Turenhout, Rob Pieters

Publikováno v: Leukemia & Lymphoma. Routledge/Taylor & Francis Group
Leukemia & Lymphoma, 55(8), 1942-1945. Informa Healthcare

Childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous disease in which the 5-year event-free survival rates are currently above 80% [1]. Yet, some genetic subtypes of...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b05ed9df0ef0a5fef12c15d276ecb3b
https://doi.org/10.3109/10428194.2013.858813

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Clinical Relevance of Tyrosine Kinase Fusion Genes in Pediatric BCR-ABL1-like Acute Lymphoblastic Leukemia

Autor: Berna Beverloo, Rob Pieters, Judith M. Boer, Aurélie Boeree, Monique L. den Boer, João R. M. Marchante, Hester A. de Groot-Kruseman, Gabriele Escherich

Publikováno v: Blood. 126:3735-3735

Background Patients with pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with the BCR-ABL1 fusion gene form a small high-risk patient group with a poor prognosis. Approximately 15% of BCP-ALL are characterized by a gene expression s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4734341be0962e4bc9cc95fcfb5d099d
https://doi.org/10.1182/blood.v126.23.3735.3735

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Targeted Therapy for ETV6-RUNX1-Driven B-Cell Precursor Acute Lymphoblastic Leukemia

Autor: Marc Bierings, Cindy S. van der Leije, Monique L. den Boer, Mathijs A. Sanders, Rosanna van den Dungen, Miranda Buitenhuis, Jan J. Cornelissen, Roel Polak, João R. M. Marchante, Rob Pieters, Onno Roovers

Publikováno v: Blood. 124:62-62

Background: Translocation t(12;21), resulting in the ETV6-RUNX1 fusion protein, is present in 25% of pediatric patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Despite the favorable prognostic parameters of this B-ALL subgroup,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::481364bd81c742dce3cdfa4f9dfece88
https://doi.org/10.1182/blood.v124.21.62.62

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