Zobrazeno 1 - 6
of 6
pro vyhledávání: '"João R C, Ramos"'
Publikováno v:
AI, Vol 4, Iss 1, Pp 303-318 (2023)
In this paper, a computational framework is proposed that merges mechanistic modeling with deep neural networks obeying the Systems Biology Markup Language (SBML) standard. Over the last 20 years, the systems biology community has developed a large n
Externí odkaz:
https://doaj.org/article/91893d6259ff4857a5c3514bab50c581
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Hybrid modeling combining First-Principles with machine learning is becoming a pivotal methodology for Biopharma 4.0 enactment. Chinese Hamster Ovary (CHO) cells, being the workhorse for industrial glycoproteins production, have been th
Externí odkaz:
https://doaj.org/article/f2f3ed691a3c4435b69a016c5e18c1be
Publikováno v:
Fermentation, Vol 9, Iss 7, p 643 (2023)
Hybrid modeling workflows combining machine learning with mechanistic process descriptions are becoming essential tools for bioprocess digitalization. In this study, a hybrid deep modeling method with state–space reduction was developed and showcas
Externí odkaz:
https://doaj.org/article/a8dade0c8dcd492e99020e271c3d7318
Publikováno v:
Fermentation; Volume 9; Issue 7; Pages: 643
Hybrid modeling workflows combining machine learning with mechanistic process descriptions are becoming essential tools for bioprocess digitalization. In this study, a hybrid deep modeling method with state–space reduction was developed and showcas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::e0362696ab9e87b1348025813928cc52
In this paper we propose a computational framework that merges mechanistic modeling with deep neural networks obeying the Systems Biology Markup Language (SBML) standard. Over the last 20 years, the systems biology community has developed a large num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa022648b19ee200ee280ee4d13fd8d
Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis
Publikováno v:
Bioprocess and biosystems engineering. 45(11)
Flux balance analysis (FBA) is currently the standard method to compute metabolic fluxes in genome-scale networks. Several FBA extensions employing diverse objective functions and/or constraints have been published. Here we propose a hybrid semi-para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10227a53069c61901f7d0b82a28d8be6
https://pubmed.ncbi.nlm.nih.gov/36245012
https://pubmed.ncbi.nlm.nih.gov/36245012