Zobrazeno 1 - 10
of 39
pro vyhledávání: '"João P. M. António"'
Autor:
Ana S. André, Joana N. R. Dias, Sandra Aguiar, Sara Nogueira, Pedro Bule, Joana Inês Carvalho, João P. M. António, Marco Cavaco, Vera Neves, Soraia Oliveira, Gonçalo Vicente, Belmira Carrapiço, Berta São Braz, Barbara Rütgen, Lurdes Gano, João D. G. Correia, Miguel Castanho, Joao Goncalves, Pedro M. P. Gois, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Antibody–drug conjugates (ADCs) are among the fastest-growing classes of therapeutics in oncology. Although ADCs are in the spotlight, they still present significant engineering challenges. Therefore, there is an urgent need to develop mor
Externí odkaz:
https://doaj.org/article/f9c1a085d74e4cbdaf2217e2c95385f7
Publikováno v:
ACS Omega, Vol 3, Iss 7, Pp 7418-7423 (2018)
Externí odkaz:
https://doaj.org/article/b844fe88fcc54db08acace9c55b8fa1d
Autor:
João Franco Machado, Fernanda Marques, Teresa Pinheiro, Maria J. Villa de Brito, Gonzalo Scalese, Leticia Pérez‐Díaz, Lucía Otero, João P. M. António, Dinorah Gambino, Tânia S. Morais
Publikováno v:
ChemMedChem.
Autor:
João P. M. António, Joana Inês Carvalho, Ana S. André, Joana N. R. Dias, Sandra I. Aguiar, Hélio Faustino, Ricardo M. R. M. Lopes, Luis F. Veiros, Gonçalo J. L. Bernardes, Frederico A. Silva, Pedro M. P. Gois
Publikováno v:
Angewandte Chemie. 133:26118-26125
Autor:
Cláudia F. Afonso, Marta C. Marques, João P. M. António, Carlos Cordeiro, Pedro M. P. Gois, Pedro M. S. D. Cal, Gonçalo J. L. Bernardes
Publikováno v:
Angewandte Chemie International Edition. 61
Post-translational modifications of histones are essential in the regulation of chromatin structure and function. Among these modifications, lysine acetylation is one of the most established. Earlier studies relied on the use of chromatin containing
Autor:
João P. M. António, Albert Gandioso, Fariba Nemati, Nancy Soliman, Robin Vinck, Fan Sun, Carine Robert, Pierre Burckel, Didier Decaudin, Christophe M. Thomas, Gilles Gasser
Publikováno v:
Chemical Science
Chemical Science, 2022, ⟨10.1039/D2SC05693C⟩
Chemical Science, 2022, ⟨10.1039/D2SC05693C⟩
The in vitro to in vivo translation of metal-based cytotoxic drugs has proven to be a significant hurdle in their establishment as effective anti-cancer alternatives. Various nano-delivery systems, such as polymeric nanoparticles, have been explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2916f62aef37da65cc3c5c021047ab7d
https://hal.science/hal-03888004
https://hal.science/hal-03888004
Publikováno v:
Organic & Biomolecular Chemistry. 19:6221-6226
In this work, we describe the preparation of a heterobifunctional 2-formylphenylboronic acid (2-FPBA)-maleimide crosslinker and explore its versatility in the preparation of various bioconjugates. We demonstrate the straightforward attachment of hydr
Autor:
Roberto Russo, Pedro M. S. D. Cal, Pedro M. P. Gois, Cátia Parente Carvalho, João P. M. António
Publikováno v:
Chemical Society reviews. 49(10)
Correction for ‘Boronic acids as building blocks for the construction of therapeutically useful bioconjugates’ by João P. M. António et al., Chem. Soc. Rev., 2019, 48, 3513–3536, DOI: 10.1039/C9CS00184K.
Autor:
Frederico Aires da Silva, Ana S. André, Joana N R Dias, Gonçalo J. L. Bernardes, João P. M. António, Joana Carvalho, Pedro M. P. Gois, Ricardo M R M Lopes, Luis F. Veiros, Hélio Faustino
Antibody-drug conjugates (ADCs) are a new class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies to selectively deliver drugs to cancer cells. The synthesis of ADCs is challenging, and stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::331cc1b9987503b9e36aa7280e0a9fbf
https://doi.org/10.33774/chemrxiv-2021-qh8zd
https://doi.org/10.33774/chemrxiv-2021-qh8zd
Autor:
Cátia Parente Carvalho, Roberto Russo, Pedro M. P. Gois, Pedro M. S. D. Cal, João P. M. António
Publikováno v:
Chemical Society Reviews
Bioconjugates are multifunctional constructs in which biomolecules like peptides, proteins, vitamins and nucleic acids are endowed with the properties of specific payloads. These constructs recently emerged as a new generation of high-precision thera