Zobrazeno 1 - 8
of 8
pro vyhledávání: '"João P. Luís"'
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
In silico methodologies have opened new avenues of research to understanding and predicting drug resistance, a pressing health issue that keeps rising at alarming pace. Sequence-based interpretation systems are routinely applied in clinical context i
Externí odkaz:
https://doaj.org/article/aad212a950484fa5b9b3b14567a1fe1e
Autor:
João Miguel Luís, Rita Files, Cláudia Cardoso, José Pimenta, Gabriela Maia, Filipe Silva, Felisbina L. Queiroga, Justina Prada, Isabel Pires
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4951-4967 (2024)
Squamous cell carcinoma (SCC) stands as the second most prevalent skin cancer in dogs, primarily attributed to UV radiation exposure. Affected areas typically include regions with sparse hair and pale or depigmented skin. The significance of spontane
Externí odkaz:
https://doaj.org/article/02f8c700222f49ccaaf2cb17a41d3f27
Autor:
Vânia André, M. Teresa Duarte, Mariama Djaló, Andreia E. S. Cunha, Auguste Fernandes, Sílvia Quaresma, João P. Luís
Publikováno v:
Crystal Growth & Design. 21:995-1005
The design of novel pharmaceutical multicomponent crystal forms has been reported as an efficient approach to tailor their physicochemical properties, including solubility. Sparfloxacin is a fluoro...
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2599
Interleukin-1 receptor type 1 (IL-1R1) is a key player in inflammation and immune responses. This receptor regulates IL-1 activity in two forms: as a membrane-bound form and as a soluble ectodomain. The details and differences between the conformatio
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1731, p 1731 (2022)
The interleukin-1 receptor type 1 (IL-1R1) holds pivotal roles in the immune system, as it is positioned at the “epicenter” of the inflammatory signaling networks. Increased levels of the cytokine IL-1 are a recognized feature of the immune respo
Publikováno v:
CLEI Electronic Journal, Vol 5, Iss 2 (2002)
This paper presents a Component-based Framework Development Process, of the Cardiology Domain. The Framework, called FrameCardio, was developed in 4 steps: 1- Problem Domain Definition, 2-Components Specifications, 3-Components Internal Design and 4-
Externí odkaz:
https://doaj.org/article/122527159b9644a7bf58994d6b97e35b
Autor:
Rui M. M. Brito, João Pereira-Vaz, João P. Luís, Carlos J. V. Simões, Nuno G. Alves, Ana I. Mata, Vitor Duque, Daniela C. Vaz
Publikováno v:
Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition.
One of the main challenges facing the development of effective anti HIV-1 medicines relates to the high mutation rate of essential enzymes, such as HIV-1 Protease (HIV1Pr).[1] Pereira Vaz et al. [2] first reported a threonine insertion at position 35
Autor:
João P. Luís, Daniela C. Vaz, João Pereira-Vaz, Vitor Duque, Nuno G. Alves, Carlos J. V. Simões, Rui M. M. Brito
Publikováno v:
Proceedings of MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition.
Over the last 30 years, HIV has grown to a pandemic status with more than 36 million people infected worldwide. Current therapies provide a significant improvement in the quality of patients’ lives, specifically the Highly Active Anti-Retroviral Th