Zobrazeno 1 - 10
of 211
pro vyhledávání: '"João Medeiros"'
Autor:
Ahmed Rohaim, Bram J. A. Vermeulen, Jing Li, Felix Kümmerer, Federico Napoli, Lydia Blachowicz, João Medeiros-Silva, Benoît Roux, Markus Weingarth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Constriction of the selectivity filter is assumed to be a hallmark of C-type inactivation in K+ channels. Using different high-resolution methods, this study shows a distinct C-type inactivation mechanism in a KcsA mutant that emulates Kv-channels.
Externí odkaz:
https://doaj.org/article/a33344fb833146c79e427734c6c04f5c
Autor:
Rhythm Shukla, João Medeiros-Silva, Anish Parmar, Bram J. A. Vermeulen, Sanjit Das, Alessandra Lucini Paioni, Shehrazade Jekhmane, Joseph Lorent, Alexandre M. J. J. Bonvin, Marc Baldus, Moreno Lelli, Edwin J. A. Veldhuizen, Eefjan Breukink, Ishwar Singh, Markus Weingarth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bi
Externí odkaz:
https://doaj.org/article/8a53feac384048deba131cc874db54f3
Autor:
Isadora Morone, Guilherme Pansardi de Andrade, Paola Soares Cardoso, Afrânio Coelho de Oliveira, Flávia Clímaco, João Medeiros, Diogo Franco
Publikováno v:
JPRAS Open, Vol 19, Iss , Pp 106-110 (2019)
The presence of mammary nodules during childhood and adolescence is somewhat unusual, generally consisting of benign lesions. Despite the range of possible diagnoses, they are generally similar in clinical terms. In the rare cases where these lesions
Externí odkaz:
https://doaj.org/article/9b727c0182d14444bddebce3989161aa
Autor:
Shehrazade Jekhmane, João Medeiros-Silva, Jing Li, Felix Kümmerer, Christoph Müller-Hermes, Marc Baldus, Benoît Roux, Markus Weingarth
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + chan
Externí odkaz:
https://doaj.org/article/4666bccf84aa4230955d529c44e30403
Autor:
Tobias Zachs, Andreas Schertel, João Medeiros, Gregor L Weiss, Jannik Hugener, Joao Matos, Martin Pilhofer
Publikováno v:
eLife, Vol 9 (2020)
Cryo-electron tomography (cryoET) has become a powerful technique at the interface of structural biology and cell biology, due to its unique ability for imaging cells in their native state and determining structures of macromolecular complexes in the
Externí odkaz:
https://doaj.org/article/1c120550bbd54b19979c2a1593731aa2
Autor:
João Medeiros-Silva, Shehrazade Jekhmane, Alessandra Lucini Paioni, Katarzyna Gawarecka, Marc Baldus, Ewa Swiezewska, Eefjan Breukink, Markus Weingarth
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Antibiotics that target the peptidoglycan precursor lipid II are promising templates for next-generation antibiotics. Here authors use solid-state NMR and monitor lipid II-binding antibiotics, such as nisin, directly in cell membranes.
Externí odkaz:
https://doaj.org/article/bd00728712b046ff860cffd2d2e6f5cd
Autor:
Parameswaran Hariharan, Elena Tikhonova, João Medeiros-Silva, Aike Jeucken, Mikhail V. Bogdanov, William Dowhan, Jos F. Brouwers, Markus Weingarth, Lan Guan
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Membrane lipids play critical roles in the structure and function of membrane-embedded transporters. Salmonella typhimurium MelB (MelBSt) is a symporter coupling melibiose translocation with a cation (Na+, Li+, or H+). We present
Externí odkaz:
https://doaj.org/article/1a7218750cc94c928372e309d5d76dd6
Autor:
Nikolai S. Espinoza, Carlos A. C. dos Santos, Madson T. Silva, Helber B. Gomes, Rosaria R. Ferreira, Maria L. da Silva, Cláudio M. Santos e Silva, Cristiano P. de Oliveira, João Medeiros, Jason Giovannettone, Venerando E. Amaro, Celso A. G. Santos, Manoranjan Mishra
Publikováno v:
Atmosphere, Vol 12, Iss 10, p 1261 (2021)
Given the increasing occurrence of landslides on the East Coast Northeast of Brazil (ECNEB), it is essential to understand its conditions and triggering factors because meteorological anomalies triggered by a landslide will threaten life and property
Externí odkaz:
https://doaj.org/article/5aa4dc45f6fa4b9cb0f808d933235d9d
Publikováno v:
Revista Brasileira de Cirurgia Plástica, Vol 31, Iss 02, Pp 192-196 (2016)
INTRODUCTION: The treatment of orofacial clefts comprises steps that may result in considerable psychological trauma for patients and their caregivers. The use of absorbable sutures may help to eliminate these uncomfortable situations. However, the e
Externí odkaz:
https://doaj.org/article/6454b42d87ce4560b3aaf4e4292b6c52
Publikováno v:
Revista Brasileira de Cirurgia Plástica, Vol 31, Iss 01, Pp 118-122 (2016)
This is a case report of a 44-year-old male patient who was admitted to the emergency room on November 17, 2013, after an accident with a Makita Disc. The patient presented with an extensive wound throughout the dorsal surface of the left thumb, with
Externí odkaz:
https://doaj.org/article/9fffb128e1904466bdf6723fbe4322f0