Výsledky vyhledávání - "João M. Trigueiro-Louro"

Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike

Autor: Helena Rebelo-de-Andrade, Marta Gíria, João M. Trigueiro-Louro, Vanessa Correia, Inês Figueiredo-Nunes

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2117-2131 (2020)
Computational and Structural Biotechnology Journal

Graphical abstract
Highlights • Human SARSr-CoV Spike protein is highly conserved in both S1 and S2 subunits. • The S1-RBD, -SD1; S2-CR, -HR1 and -CH are the most promising druggable S regions. • 28 main consensus druggable pockets were fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63598730c179325ddc5c9d3b95a8608
http://www.sciencedirect.com/science/article/pii/S2001037020303494

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Optimization of A(H1N1)pdm09 vaccine seed viruses: The source of PB1 and HA vRNA as a major determinant for antigen yield

Autor: Filipe Almeida, Luís A. Santos, João M. Trigueiro-Louro, Helena Rebelo-de-Andrade

Publikováno v: Virus Research. 315:198795

Vaccination prevents and reduces the severity of influenza virus infections. Continuous evolution of influenza hemagglutinin (HA) and neuraminidase (NA) supports the virus to evade pre-existing immunity, which demands vaccines to be reformulated ever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16308c8f15dfdfe8c93cb8ccfe3e2c97
https://doi.org/10.1016/j.virusres.2022.198795

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To hit or not to hit: large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential

Autor: Rita C. Guedes, Luís A. Santos, Helena Rebelo-de-Andrade, João M. Trigueiro-Louro, Rui M. M. Brito, Vanessa Correia

Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. Notwithstanding, drug development guidance based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d352a1f50c1bdb91a6a8e664f49c81e5
https://hdl.handle.net/10400.18/6649

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