Zobrazeno 1 - 10
of 83
pro vyhledávání: '"João Luís Reis-Cunha"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Trypanosomatid parasites are a group of protozoans that cause devastating diseases that disproportionately affect developing countries. These protozoans have developed several mechanisms for adaptation to survive in the mammalian
Externí odkaz:
https://doaj.org/article/c2de2617d3cd404481828415be688014
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-6 (2024)
Abstract Background Gene families are groups of homologous genes that often have similar biological functions. These families are formed by gene duplication events throughout evolution, resulting in multiple copies of an ancestral gene. Over time, th
Externí odkaz:
https://doaj.org/article/2943ce5ea26646df9cd39ecf55935048
Autor:
Davi Alvarenga Lima, Leilane Oliveira Gonçalves, João Luís Reis-Cunha, Paul Anderson Souza Guimarães, Jeronimo Conceição Ruiz, Daniel Barbosa Liarte, Silvane Maria Fonseca Murta
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-18 (2023)
Abstract Background Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a serious public health concern in Latin America. Nifurtimox and benznidazole (BZ), the only two drugs currently approved for the treatment of CD, have very low eff
Externí odkaz:
https://doaj.org/article/0392c77ba8624f1ca7824862a93caf18
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Leishmania are kinetoplastid pathogens that cause leishmaniasis, a debilitating and potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene expression largely post-transcriptionally due to the arrangement of the
Externí odkaz:
https://doaj.org/article/60d618f6a1344a8fac396716aed98a96
Autor:
Cooper Alastair Grace, Kátia Silene Sousa Carvalho, Mayara Ingrid Sousa Lima, Vladimir Costa Silva, João Luís Reis-Cunha, Matthew J. Brune, Sarah Forrester, Conceição de Maria Pedrozo e Silva de Azevedo, Dorcas Lamounier Costa, Doug Speed, Jeremy C. Mottram, Daniel C. Jeffares, Carlos H. N. Costa
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Visceral leishmaniasis (VL) is a potentially fatal disease caused mainly by Leishmania infantum in South America and Leishmania donovani in Asia and Africa. Disease outcomes have been associated with patient genotype, nutrition, age, sex, co
Externí odkaz:
https://doaj.org/article/24a164081d5f43409198d2fbd9025a5b
Autor:
João Luís Reis-Cunha, Anderson Coqueiro-dos-Santos, Samuel Alexandre Pimenta-Carvalho, Larissa Pinheiro Marques, Gabriela F. Rodrigues-Luiz, Rodrigo P. Baptista, Laila Viana de Almeida, Nathan Ravi Medeiros Honorato, Francisco Pereira Lobo, Vanessa Gomes Fraga, Lucia Maria da Cunha Galvão, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara, Mariana Santos Cardoso, Gustavo Coutinho Cerqueira, Daniella C. Bartholomeu
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Repetitive elements cause assembly fragmentation in complex eukaryotic genomes, limiting the study of their variability. The genome of Trypanosoma cruzi, the parasite that causes Chagas disease, has a high repetitive content, including multi
Externí odkaz:
https://doaj.org/article/ba5075b9a21e493ead3788e470e0b902
Autor:
Viviane Corrêa Santos, Antonio Edson Rocha Oliveira, Augusto César Broilo Campos, João Luís Reis-Cunha, Daniella Castanheira Bartholomeu, Santuza Maria Ribeiro Teixeira, Ana Paula C. A. Lima, Rafaela Salgado Ferreira
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Cruzipains are the main papain-like cysteine proteases of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease. Encoded by a multigenic family, previous studies have estimated the presence of dozens of copies spread over mult
Externí odkaz:
https://doaj.org/article/04782922325f4c48a209e0ed361ee524
Autor:
Ana Maria Murta Santi, Juliana Martins Ribeiro, João Luís Reis-Cunha, Gabriela de Assis Burle-Caldas, Isabella Fernandes Martins Santos, Paula Alves Silva, Daniela de Melo Resende, Daniella Castanheira Bartholomeu, Santuza Maria Ribeiro Teixeira, Silvane Maria Fonseca Murta
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 10 (2022)
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a serious chronic parasitic disease, currently treated with Nifurtimox (NFX) and Benznidazole (BZ). In addition to high toxicity, these drugs have low healing efficacy, especially in the c
Externí odkaz:
https://doaj.org/article/8959fab4bb0846448762a5eaf6da1057
Autor:
Danielle Rodrigues Cortez, Fabio Mitsuo Lima, João Luís Reis-Cunha, Daniella Castanheira Bartholomeu, Rolando Andre Rios Villacis, Silvia Regina Rogatto, André Guilherme Costa-Martins, Fernanda Sycko Marchiano, Rafaela Andrade do Carmo, Jose Franco da Silveira, Marjorie Mendes Marini
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits extensive inter- and intrastrain genetic diversity. As we have previously described, there are some genetic differences between the parental G strain and its clone D11, which was is
Externí odkaz:
https://doaj.org/article/3cb6e172430747cf9b62a4fbf6e5e929
Autor:
Rohit Sharma, Francys Avendaño Rangel, João Luís Reis-Cunha, Larissa Pinheiro Marques, Claudio P. Figueira, Pedro B. Borba, Sayonara M. Viana, Tom Beneke, Daniella C. Bartholomeu, Camila I. de Oliveira
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Leishmania braziliensis is the main causative agent of Tegumentary Leishmaniasis in the Americas. However, difficulties related to genome manipulation, experimental infection, and parasite growth have so far limited studies with this species. CRISPR-
Externí odkaz:
https://doaj.org/article/8a1885cefb254ad9a2caa9b9b29cff7e