Zobrazeno 1 - 10
of 240
pro vyhledávání: '"João Leandro"'
Autor:
Renan Ramalho Geraldes, Sergio Augusto Lordano Luiz, João Leandro de Brito Neto, Telles René Silva Soares, Ricardo Donizeth dos Reis, Guilherme A. Calligaris, Gert Witvoet, J. P. M. B. Vermeulen
Publikováno v:
Journal of Synchrotron Radiation, Vol 30, Iss 1, Pp 90-110 (2023)
The High-Dynamic Double-Crystal Monochromator (HD-DCM) is a mechatronic system with unique control-based architecture and deep paradigm changes as compared with traditional beamline monochromators. Aiming at unprecedented inter-crystal positioning st
Externí odkaz:
https://doaj.org/article/e4af5e1c62e94aafb2878b41d0e81d0f
Autor:
João Leandro, Susmita Khamrui, Chalada Suebsuwong, Peng-Jen Chen, Cody Secor, Tetyana Dodatko, Chunli Yu, Roberto Sanchez, Robert J. DeVita, Sander M. Houten, Michael B. Lazarus
Publikováno v:
Open Biology, Vol 12, Iss 9 (2022)
In humans, a single enzyme 2-aminoadipic semialdehyde synthase (AASS) catalyses the initial two critical reactions in the lysine degradation pathway. This enzyme evolved to be a bifunctional enzyme with both lysine-2-oxoglutarate reductase (LOR) and
Externí odkaz:
https://doaj.org/article/5d1f92da3b604957856043910867cf16
Autor:
Natalia S. Nemeria, Balint Nagy, Roberto Sanchez, Xu Zhang, João Leandro, Attila Ambrus, Sander M. Houten, Frank Jordan
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8213 (2022)
The human 2-oxoadipate dehydrogenase complex (OADHc) in L-lysine catabolism is involved in the oxidative decarboxylation of 2-oxoadipate (OA) to glutaryl-CoA and NADH (+H+). Genetic findings have linked the DHTKD1 encoding 2-oxoadipate dehydrogenase
Externí odkaz:
https://doaj.org/article/1ce9ea30fab44e5f9cfaacc6994960f6
Autor:
Gabriela Bastos Cabral, João Leandro de Paula Ferreira, Renato Pereira de Souza, Mariana Sequetin Cunha, Adriana Luchs, Cristina Adelaide Figueiredo, Luís Fernando de Macedo Brígido
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 113, Iss 1, Pp 38-44 (2017)
BACKGROUND A number of Zika virus (ZIKV) sequences were obtained using Next-generation sequencing (NGS), a methodology widely applied in genetic diversity studies and virome discovery. However Sanger method is still a robust, affordable, rapid and sp
Externí odkaz:
https://doaj.org/article/b18d01008f244421ba6b9f3c2fb2704a
Autor:
Paulo R. Lino, João Leandro, Lara Figueiredo, Mariana P. Amaro, Lídia M. D. Gonçalves, Paula Leandro, António J. Almeida
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7987 (2021)
Polymeric-based nano drug delivery systems have been widely exploited to overcome protein instability during formulation. Presently, a diverse range of polymeric agents can be used, among which polysaccharides, such as chitosan (CS), hyaluronic acid
Externí odkaz:
https://doaj.org/article/3fa4e0178b7a46d0960af9341149f1ed
Publikováno v:
FEBS Open Bio, Vol 7, Iss 7, Pp 1026-1036 (2017)
Mammalian phenylalanine hydroxylase (PAH) is a key enzyme in l‐phenylalanine (l‐Phe) metabolism and is active as a homotetramer. Biochemical and biophysical work has demonstrated that it cycles between two states with a variably low and a high ac
Externí odkaz:
https://doaj.org/article/42c8efbce0d54fe8ac7f5f75f891e932
Autor:
Giselle de Faria Romero Soldi, Isadora Coutinho Ribeiro, Cintia Mayumi Ahagon, Luana Portes Ozório Coelho, Gabriela Bastos Cabral, Giselle Ibette Silva López Lopes, João Leandro de Paula Ferreira, Luís Fernando de Macedo Brígido, Salvage Therapy Working Group
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223210 (2019)
BACKGROUND:Protease inhibitors (PI) are especially important in salvage therapy. Previous treatment failure with a PI containing regimen may elicit resistance mutations, reducing PI susceptibility and limiting treatment options. The aim of this study
Externí odkaz:
https://doaj.org/article/6a65b7e9f64d419c9f35d3897a367361
Autor:
Raquel R. Lopes, Catarina S. Tomé, Roberto Russo, Roberta Paterna, João Leandro, Nuno R. Candeias, Lídia M. D. Gonçalves, Miguel Teixeira, Pedro M. F. Sousa, Rita C. Guedes, João B. Vicente, Pedro M. P. Gois, Paula Leandro
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 462 (2021)
Phenylketonuria (PKU) is a genetic disease caused by deficient activity of human phenylalanine hydroxylase (hPAH) that, when untreated, can lead to severe psychomotor impairment. Protein misfolding is recognized as the main underlying pathogenic mech
Externí odkaz:
https://doaj.org/article/930e60cb46ef4088b66394b0dbb9f7c4
Autor:
Paulo R. Lino, João Leandro, Mariana Amaro, Lídia M. D. Gonçalves, Paula Leandro, António J. Almeida
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 329 (2021)
Enzyme nanoencapsulation holds an enormous potential to develop new therapeutic approaches to a large set of human pathologies including cancer, infectious diseases and inherited metabolic disorders. However, enzyme formulation has been limited by th
Externí odkaz:
https://doaj.org/article/513475fa66e6499b93376a9b6e2b3192
Autor:
Maria Isabel de Oliveira, Gislene Mitsue Namiyama, Gabriela Bastos Cabral, João Leandro Ferreira, Noemi Taniwaki, Ana Maria Sardinha Afonso, Isabella Rillo Lima, Luís Fernando Macedo de Brigido
Publikováno v:
Revista do Instituto de Medicina Tropical de São Paulo, Vol 60, Iss 0 (2018)
ABSTRACT A great variety of viruses which cause exanthema share other clinical manifestations, making the etiologic identification a very difficult task, relying exclusively on the clinical examination. Rubella virus (RV) infection during the early s
Externí odkaz:
https://doaj.org/article/ce70f2c8c51f486792730dd430ed85e7