Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review

Autor: João Kleber Novais Pereira, Marília Berlofa Visacri, Nicolás Saavedra, Kathleen Saavedra, Nadine de Godoy Torso, Pedro Eduardo Nascimento Silva Vasconcelos, Luis A. Salazar, Pía Loren, Patricia Moriel

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12765, p 12765 (2021)

The purpose of this systematic review was to map out and summarize scientific evidence on dysregulated microRNAs (miRNAs) that can be possible biomarkers or therapeutic targets for cisplatin nephrotoxicity and have already been tested in humans, anim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafbc31d5e4e4b400e8fe8045b3a14a5
https://pubmed.ncbi.nlm.nih.gov/34884570

IL32 expression in peripheral blood CD3+ cells from myelodysplastic syndromes patients

Autor: Sara Teresinha Olalla Saad, Paula de Melo Campos, Patricia Favaro, João Agostinho Machado-Neto, Matheus Rodrigues Lopes, João Kleber Novais Pereira, Fabiola Traina

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Applied Cancer Research, Vol 37, Iss 1, Pp 1-6 (2017)

Myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by ineffective hematopoiesis and risk of leukemia transformation. There is evidence to suggest the participation of immune system deregulation in MDS pathogenesis. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4102a6321994c1ed87c4cdc79642f9b

FMNL1 promotes proliferation and migration of leukemia cells

Autor: João Kleber Novais Pereira, Anne J. Ridley, Sara Teresinha Olalla Saad, Elvira Infante, Fernando Ferreira Costa, João Agostinho Machado-Neto, Matheus Rodrigues Lopes, Patricia Favaro, Mariana Lazarini, Fabiola Traina

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The human FMNL1 is expressed predominantly in hematopoietic cells and has been described previously as overexpressed in hematopoietic malignancies. However, it is not known whether FMNL1 contributes to leukemogenesis. Here, we investigate the FMNL1 f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c830bbb8ee3421e5d0dfda235ab0bde7
https://pubmed.ncbi.nlm.nih.gov/23801653

Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients

Autor: Patricia Favaro, João Agostinho Machado-Neto, João Kleber Novais Pereira, Fabiola Traina, Adriana S. S. Duarte, Sara Teresinha Olalla Saad, Matheus Rodrigues Lopes

Publikováno v: Leukemia research. 36(10)

a b s t r a c t Recent studies have indicated the Musashi2/NUMB pathway as the key regulator of differentiation in chronic myeloid leukemia; however, a comparison of both gene expressions has not yet been made in myelodysplastic syndrome (MDS) and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f20beec0e7190a293d9bf75ad425c84
https://pubmed.ncbi.nlm.nih.gov/22784712

FMNL1 Is Downregulated In Myelodysplastic Syndromes and Is Involved In Megakaryocytic Differentiation

Autor: Matheus Rodrigues Lopes, João Agostinho Machado-Neto, Fabiola Traina, João Kleber Novais Pereira, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Teresinha Olalla Saad, Patricia Favaro

Publikováno v: Blood. 122:1519-1519

Background Myelodysplastic syndromes (MDS) are disorders characterized by morphological dysplasia, impaired differentiation and defective cellular functions, resulting in peripheral cytopenias. FMNL1 belongs to a family of formin-related proteins, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9ebbf399e7698feada24f0cb132343f
https://doi.org/10.1182/blood.v122.21.1519.1519