Zobrazeno 1 - 10
of 135
pro vyhledávání: '"João José Freitas Sarkis"'
Autor:
Alessandra Nejar Bruno, Andréia Buffon, Maria Luiza Morais Barreto-Chaves, Marcela Sorelli Carneiro-Ramos, Daniela Pochmann, João José Freitas Sarkis, Felipe Klein Ricachenevsky
Publikováno v:
BioFactors. 37:40-45
The effects of ATP, ADP, and adenosine in the processes of platelet aggregation, vasodilatation, and coronary flow have been known for many years. The sequential hydrolysis of ATP to adenosine by soluble nucleotidases constitutes the main system for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a50d7807e0db327ead680e3621d920
https://doi.org/10.1002/biof.133
https://doi.org/10.1002/biof.133
Autor:
Ana Elisa Böhmer, João José Freitas Sarkis, Alcyr Alves de Oliveira, Diogo O. Souza, Maurício Reis Bogo, Cristiane Batassini, Tadeu Mello e Souza, Daniela Pochmann, Jean Pierre Oses, Luis Valmor Cruz Portela, Carla Denise Bonan, Fernanda Cenci Vuaden, Roberta Bristot Silvestrin
Publikováno v:
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Parkinson's disease (PD) is characterized by a progressive neurodegeneration in the substantia nigra and a striatal dopamine decrease. Striatal extracellular adenosine and ATP modulate the dopaminergic neurotransmission whereas guanosine has a protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051a5966eecb93b0804ea75f483f5ab9
https://doi.org/10.1007/s11064-010-0305-1
https://doi.org/10.1007/s11064-010-0305-1
Autor:
Andréia Buffon, Emerson André Casali, Valesca Veiga Cardoso, Luiz F. Zerbini, Simon C. Robson, João José Freitas Sarkis, Márcia Rosângela Wink
Publikováno v:
Life Sciences. 86:435-440
Aims Expression of ectoenzymes responsible for nucleotide phosphohydrolysis to form adenosine may represent a mechanism that facilitates the proliferation and spread of malignancy. In this study, we have identified and characterized the ectonucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d8c30f7ac76f528a3006b926037d3e
https://doi.org/10.1016/j.lfs.2010.01.015
https://doi.org/10.1016/j.lfs.2010.01.015
Autor:
Carlos Alexandre Netto, Giana de Paula Cognato, João José Freitas Sarkis, Angela T. S. Wyse, Carla Denise Bonan, Janaína Kolling, Denise Barbosa Ramos, Maurício Reis Bogo, Caren Serra Bavaresco, Fabria Chiarani
Publikováno v:
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
The aim of this study was to investigate the effects of intrastriatal injection of hypoxanthine on ectonucleotidase (E-NTPDases and ecto-5′-nucleotidase) activities and expressions in the striatum of rats. The effect of pre-treatment with vitamins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b43224bd75c6e092b473cb9add046bb
https://doi.org/10.1016/j.brainres.2008.08.015
https://doi.org/10.1016/j.brainres.2008.08.015
Autor:
Fernanda Francine Zimmermann, Eduardo Luiz Pedrazza, Leonardo Pedrazza, Maurício Reis Bogo, João José Freitas Sarkis, Carla Denise Bonan, Eduardo Pacheco Rico, Mario Roberto Senger
Publikováno v:
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Depression is one of the most disabling diseases and causes a significant burden to both individual and society. Selective serotonin reuptake inhibitors and tricyclic antidepressants, such as fluoxetine and nortriptyline, respectively, are commonly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892e0d4a9a3cdd42611f12b88bb24d9d
https://doi.org/10.1016/j.ejphar.2008.01.013
https://doi.org/10.1016/j.ejphar.2008.01.013
Autor:
Bárbara Rücker, Márcia Rosângela Wink, Towia A. Libermann, Luiz F. Zerbini, Manoela E. Almeida, João José Freitas Sarkis
Publikováno v:
Life Sciences. 82:477-486
In this study, we have identified the E-NTPDase family members and ecto-5'-nucleotidase/CD73 in rat heart left ventricle. Moreover, we characterize the biochemical properties and enzyme activities from synaptosomes of the nerve terminal endings of he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6643094a86a772513bd47a08296fac1
https://doi.org/10.1016/j.lfs.2007.12.003
https://doi.org/10.1016/j.lfs.2007.12.003
Autor:
Bárbara Rücker, Márcia Rosângela Wink, Towia A. Libermann, João José Freitas Sarkis, Manoela E. Almeida, Luiz F. Zerbini
Publikováno v:
Molecular and Cellular Biochemistry. 306:247-254
In the present study we investigate the biochemical properties of the members of NPP family in synaptosomes prepared from rat heart left ventricles. Using p-nitrophenyl-5′-thymidine monophosphate (p-Nph-5′-TMP) as substrate for E-NPPs in rat card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d8031290d6b338985b3ea0a172ddb8
https://doi.org/10.1007/s11010-007-9576-5
https://doi.org/10.1007/s11010-007-9576-5
Publikováno v:
Brain Research. 1149:210-215
In the present study we investigated the in vivo (acute and chronic) and in vitro effects of proline on NTPDase and 5′-nucleotidase activities in synaptosomes obtained from cerebral cortex of rats. For acute administration, 29-day-old rats received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdeed88f42c945af37140d88e2e16b76
https://doi.org/10.1016/j.brainres.2007.02.053
https://doi.org/10.1016/j.brainres.2007.02.053
Autor:
Cristina Bonorino, Carla Denise Bonan, Maurício Reis Bogo, Giana de Paula Cognato, Fernanda Cenci Vuaden, João José Freitas Sarkis
Publikováno v:
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
ATP exerts a proinflammatory role and induces cytokine release by acting at P2X(7) receptors. The product of ATP hydrolysis is the nucleoside adenosine, an important immunomodulator. The main source of extracellular adenosine is the hydrolysis of ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7ecb8618f829249556e6af14d4fbf0
https://doi.org/10.1016/j.lfs.2007.02.015
https://doi.org/10.1016/j.lfs.2007.02.015
Autor:
Emerson André Casali, João José Freitas Sarkis, Vanessa Bley Ribeiro, Márcia Rosângela Wink, Andréia Buffon
Publikováno v:
Life Sciences. 80:950-958
In this study we describe the molecular identification, kinetic characterization and biochemical properties of an E-NTPDase and an 5′-nucleotidase in Walker 256 cells. For the ATP, ADP and AMP hydrolysis there were optimum pH in the range 6.5–8.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2678e27a8d9a4466a5e64a5f66dfaea
https://doi.org/10.1016/j.lfs.2006.11.024
https://doi.org/10.1016/j.lfs.2006.11.024