ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the C. elegans Intestine

Autor: Jorian J. Sepers, João J. Ramalho, Jason R. Kroll, Ruben Schmidt, Mike Boxem

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Reorganization of the plasma membrane and underlying actin cytoskeleton into specialized domains is essential for the functioning of most polarized cells in animals. Proteins of the ezrin-radixin-moesin (ERM) and Na+/H+ exchanger 3 regulating factor

Externí odkaz: https://doaj.org/article/9f750acc43c04299b78d0bdf46c2e385

ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the

Autor: Jorian J, Sepers, João J, Ramalho, Jason R, Kroll, Ruben, Schmidt, Mike, Boxem

Publikováno v: Frontiers in cell and developmental biology. 10

Reorganization of the plasma membrane and underlying actin cytoskeleton into specialized domains is essential for the functioning of most polarized cells in animals. Proteins of the ezrin-radixin-moesin (ERM) and Na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c14678f203a1ee0a3b4edd9071f7fbff
https://pubmed.ncbi.nlm.nih.gov/35198555

BBLN-1 is essential for intermediate filament organization and apical membrane morphology

Autor: Milena Pasolli, Maarten Altelaar, Suzanne van der Horst, Sanne Remmelzwaal, Florian Geisler, Christine Richardson, Riccardo Stucchi, Mike Boxem, Jason R. Kroll, João J. Ramalho, Rudolf E. Leube, Anna Akhmanova, Olga D. Jarosinska

Epithelial tubes are essential components of metazoan organ systems that control the flow of fluids and the exchange of materials between body compartments and the outside environment. The size and shape of the central lumen confer important characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54a3871a30aa76424e678c99b5d25899
https://doi.org/10.1101/2020.12.04.411520

In vivo control of the ezrin/radixin/moesin protein ERM-1 in C. elegans

Autor: Ophélie Nicolle, Mike Boxem, João J. Ramalho, Grégoire Michaux

ERM proteins are conserved regulators of cortical membrane specialization, that function as membrane–actin linkers and molecular hubs. Activity of ERM proteins requires a conformational switch from an inactive cytoplasmic form into an active membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1315eb4e91046974d32ac9d7442e97b7

Copper impairs the intestinal barrier integrity in Wilson disease.

Autor: Fontes A; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; DCV-Department of Life Sciences, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal., Pierson H; Department of Physiology, Johns Hopkins Medical Institutes, Baltimore, MD, USA., Bierła JB; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Eberhagen C; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Kinschel J; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Akdogan B; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Rieder T; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Sailer J; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Reinold Q; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Cielecka-Kuszyk J; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Szymańska S; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Neff F; Munich Clinic Harlaching, Munich, Germany., Steiger K; Comparative Experimental Pathology Department, Institute for General Pathology and Pathological Anatomy, Technical University of Munich (TUM), Germany., Seelbach O; Comparative Experimental Pathology Department, Institute for General Pathology and Pathological Anatomy, Technical University of Munich (TUM), Germany., Zibert A; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany., Schmidt HH; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany., Hauck SM; Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Munich, Germany., von Toerne C; Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Munich, Germany., Michalke B; Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Semrau JD; Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, MI, 48109-2125, USA., DiSpirito AM; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, USA., Ramalho-Santos J; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; DCV-Department of Life Sciences, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal; CIBB-Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Kroemer G; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-, HP, Paris, France., Polishchuk R; Telethon Institute of Genetics and Medicine, 80078 Pozzuoli, Italy., Azul AM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB-Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal; IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., DiSpirito A; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, USA., Socha P; Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Lutsenko S; Department of Physiology, Johns Hopkins Medical Institutes, Baltimore, MD, USA., Zischka H; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany. Electronic address: hans.zischka@helmholtz-munich.de.

Publikováno v: Metabolism: clinical and experimental [Metabolism] 2024 Sep; Vol. 158, pp. 155973. Date of Electronic Publication: 2024 Jul 08.