ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the C. elegans Intestine

Autor: Jorian J. Sepers, João J. Ramalho, Jason R. Kroll, Ruben Schmidt, Mike Boxem

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Reorganization of the plasma membrane and underlying actin cytoskeleton into specialized domains is essential for the functioning of most polarized cells in animals. Proteins of the ezrin-radixin-moesin (ERM) and Na+/H+ exchanger 3 regulating factor

Externí odkaz: https://doaj.org/article/9f750acc43c04299b78d0bdf46c2e385

ERM-1 phosphorylation and NRFL-1 redundantly control lumen formation in the C. elegans intestine

Autor: João J. Ramalho, Jason R. Kroll, Ruben Schmidt, Jorian J. Sepers, Mike Boxem

Reorganization of the plasma membrane and underlying actin cytoskeleton into specialized domains is essential for the functioning of most polarized cells in animals. Proteins of the ezrin-radixin-moesin (ERM) and Na+/H+ exchanger 3 regulating factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5834deb0bce224192be55b2bf20a99df
https://doi.org/10.1101/2021.09.02.458700

Characterization of the composition and functioning of the Crumbs complex in C. elegans

Autor: Victoria G Castiglioni, Hanna van Beuzekom, Riccardo Stucchi, João J. Ramalho, Maarten Altelaar, Jason R. Kroll, Ruben Schmidt, Mike Boxem

The apical domain of epithelial cells can acquire a diverse array of morphologies and functions, which is critical for the function of epithelial tissues. The Crumbs proteins are evolutionary conserved transmembrane proteins with essential roles in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c9ca482ca758451ff5a82385ce28de3
https://doi.org/10.1101/2021.08.10.455623

C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during

Autor: João J, Ramalho, Jorian J, Sepers, Ophélie, Nicolle, Ruben, Schmidt, Janine, Cravo, Grégoire, Michaux, Mike, Boxem

Publikováno v: Development (Cambridge, England). 147(14)

ERM proteins are conserved regulators of cortical membrane specialization that function as membrane-actin linkers and molecular hubs. The activity of ERM proteins requires a conformational switch from an inactive cytoplasmic form into an active membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b96cb9981fc13123f2ee4d89430b713
https://pubmed.ncbi.nlm.nih.gov/32586975

Copper impairs the intestinal barrier integrity in Wilson disease.

Autor: Fontes A; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; DCV-Department of Life Sciences, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal., Pierson H; Department of Physiology, Johns Hopkins Medical Institutes, Baltimore, MD, USA., Bierła JB; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Eberhagen C; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Kinschel J; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Akdogan B; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Rieder T; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Sailer J; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Reinold Q; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Cielecka-Kuszyk J; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Szymańska S; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Neff F; Munich Clinic Harlaching, Munich, Germany., Steiger K; Comparative Experimental Pathology Department, Institute for General Pathology and Pathological Anatomy, Technical University of Munich (TUM), Germany., Seelbach O; Comparative Experimental Pathology Department, Institute for General Pathology and Pathological Anatomy, Technical University of Munich (TUM), Germany., Zibert A; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany., Schmidt HH; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany., Hauck SM; Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Munich, Germany., von Toerne C; Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Munich, Germany., Michalke B; Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Semrau JD; Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, MI, 48109-2125, USA., DiSpirito AM; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, USA., Ramalho-Santos J; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; DCV-Department of Life Sciences, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal; CIBB-Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Kroemer G; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-, HP, Paris, France., Polishchuk R; Telethon Institute of Genetics and Medicine, 80078 Pozzuoli, Italy., Azul AM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB-Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal; IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., DiSpirito A; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, USA., Socha P; Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Lutsenko S; Department of Physiology, Johns Hopkins Medical Institutes, Baltimore, MD, USA., Zischka H; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany. Electronic address: hans.zischka@helmholtz-munich.de.

Publikováno v: Metabolism: clinical and experimental [Metabolism] 2024 Sep; Vol. 158, pp. 155973. Date of Electronic Publication: 2024 Jul 08.