Zobrazeno 1 - 10
of 26
pro vyhledávání: '"João I, Mamede"'
Autor:
Egon A. Ozer, Lacy M. Simons, Olubusuyi M. Adewumi, Adeola A. Fowotade, Ewean C. Omoruyi, Johnson A. Adeniji, Oluseyi A. Olayinka, Taylor J. Dean, Janet Zayas, Pavan P. Bhimalli, Michelle K. Ash, Almoustapha I. Maiga, Anou M. Somboro, Mamoudou Maiga, Adam Godzik, Jeffrey R. Schneider, João I. Mamede, Babafemi O. Taiwo, Judd F. Hultquist, Ramon Lorenzo-Redondo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
SARS-CoV-2 genomic surveillance has been important for informing pandemic responses but many regions remain under-sampled, limiting knowledge of circulating strains. Here, the authors sequence 378 isolates from Nigeria and identify two strains that a
Externí odkaz:
https://doaj.org/article/60700a3299f04c3ca6c1112d62d4fc0a
Autor:
Christopher B. Forsyth, Lijuan Zhang, Abhinav Bhushan, Barbara Swanson, Li Zhang, João I. Mamede, Robin M. Voigt, Maliha Shaikh, Phillip A. Engen, Ali Keshavarzian
Publikováno v:
Microorganisms, Vol 10, Iss 10, p 1996 (2022)
The coronavirus disease 2019 (COVID-19) pandemic began in January 2020 in Wuhan, China, with a new coronavirus designated SARS-CoV-2. The principal cause of death from COVID-19 disease quickly emerged as acute respiratory distress syndrome (ARDS). A
Externí odkaz:
https://doaj.org/article/21ad84a3bbaf4548a1885b9ea35e74a1
Autor:
Janet P. Zayas, João I. Mamede
Publikováno v:
Viruses, Vol 14, Iss 2, p 404 (2022)
HIV mainly targets CD4+ T cells, from which Th17 cells represent a major cell type, permissive, and are capable of supporting intracellular replication at mucosal sites. Th17 cells possess well-described dual roles, while being central to maintaining
Externí odkaz:
https://doaj.org/article/a850aaddff6948e5a788f4694854bfca
Autor:
Aabha I. Sharma, Cheryl L. Olson, João I. Mamede, Felipe Gazos-Lopes, Conrad L. Epting, Igor C. Almeida, David M. Engman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Cilia play important roles in cell signaling, facilitated by the unique lipid environment of a ciliary membrane containing high concentrations of sterol-rich lipid rafts. The African trypanosome Trypanosoma brucei is a single-celled eukaryot
Externí odkaz:
https://doaj.org/article/c329ff680ea940cfbaf9daa2d9cbf096
Publikováno v:
Viruses, Vol 13, Iss 3, p 386 (2021)
During the last decade, there was a marked increase in the development of tools and techniques to study the molecular mechanisms of the HIV replication cycle by using fluorescence microscopy. Researchers often apply the fusion of tags and fluorophore
Externí odkaz:
https://doaj.org/article/3db2e5a561e944638d6c68171069bf22
Autor:
Courtney Nguyen, Danielle L. Swaney, Lars Pache, Hong M. Moulton, David A. Stein, Shashank Tripathi, Dexter Pratt, Trey Ideker, Stephen Soonthornvacharin, David Jimenez-Morales, Maite Sanchez-Aparicio, Nish Beltran-Raygoza, Paul D. De Jesus, Randy A. Albrecht, Kelsey M. Haas, Adolfo García-Sastre, Judd F. Hultquist, João I. Mamede, Guojun Wang, Laura Martin-Sancho, Ariel Rodriguez-Frandsen, Christopher Churas, Max W. Chang, Sara Brin Rosenthal, Thong T. Nguyen, Nevan J. Krogan, Sumit K. Chanda, Michael J. McGregor, Laura Riva, Christopher Benner
Publikováno v:
Nature microbiology, vol 6, iss 10
Nat Microbiol
Nat Microbiol
The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and viral evasion strategies. To illuminate the landscape of IAV cellular restriction, we generated and integrated global geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b8b7933cc7d6e1aee1e78f2f5ec156
https://doi.org/10.1038/s41564-021-00964-2
https://doi.org/10.1038/s41564-021-00964-2
Autor:
Lacy M. Simons, Egon A. Ozer, Stephanie Gambut, Taylor J. Dean, Li Zhang, Pavan Bhimalli, Jeffrey R. Schneider, João I. Mamede, Michael G. Ison, Reem Karmali, Leo I. Gordon, Ramon Lorenzo‐Redondo, Judd F. Hultquist
Publikováno v:
Transplant Infectious Disease. 24
The continuing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with decreased susceptibility to neutralizing antibodies is of clinical importance. Several spike mutations associated with immune escape have evolved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f035129d603a495d348a33cb558125
https://doi.org/10.1111/tid.13914
https://doi.org/10.1111/tid.13914
Autor:
Michelle K. Ash, Pavan P. Bhimalli, Byoung-Kyu Cho, Basil Baby Mattamana, Stéphanie Gambut, Imad Tarhoni, Cristina L. Fhied, Anjelica F. Reyes, Samantha J. Welninski, Jaison Arivalagan, Fernanda Negrão, Renu Goel, Todd L. Beck, Thomas J. Hope, Beverly E. Sha, Young Ah Goo, Lena Al-Harthi, João I. Mamede, Jeffrey A. Borgia, Neil L. Kelleher, Jeffrey R. Schneider
Publikováno v:
Cell reports.
Although vaccination efforts have expanded, there are still gaps in our understanding surrounding the immune response to SARS-CoV-2. Measuring IgG Fc glycosylation provides insight into an infected individual's inflammatory state, among other functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f977381326aa190aa1b15816a348f28
https://pubmed.ncbi.nlm.nih.gov/36493786
https://pubmed.ncbi.nlm.nih.gov/36493786
Autor:
Adarsh Dharan, Sarah Talley, Abhishek Tripathi, João I Mamede, Matthias Majetschak, Thomas J Hope, Edward M Campbell
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005700 (2016)
Following envelope mediated fusion, the HIV-1 core is released into the cytoplasm of the target cell and undergoes a series of trafficking and replicative steps that result in the nuclear import of the viral genome, which ultimately leads to the inte
Externí odkaz:
https://doaj.org/article/3c4afb2c571d4540870ef21c9133dfe1
Autor:
Sunnie M Yoh, João I. Mamede, Derrick Lau, Narae Ahn, Maria T Sánchez-Aparicio, Joshua Temple, Andrew Tuckwell, Nina V. Fuchs, Gianguido C. Cianci, Laura Riva, Heather Curry, Xin Yin, Stéphanie Gambut, Lacy M. Simons, Judd F. Hultquist, Renate König, Yong Xiong, Adolfo García-Sastre, Till Böcking, Thomas J. Hope, Sumit K. Chanda
SUMMARYCyclic GMP-AMP synthase (cGAS) is a primary sensor of aberrant DNA that governs an innate immune signaling cascade, leading to the induction of the type-I interferon response. We have previously identified polyglutamine binding protein 1, PQBP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f207e1751338e188b0ab341b2dd6cbf
https://doi.org/10.1101/2022.01.10.472699
https://doi.org/10.1101/2022.01.10.472699
