Zobrazeno 1 - 10
of 128
pro vyhledávání: '"João F Passos"'
Autor:
Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen Richard Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/6b2cf351d8cb4f19aed05575781ae9dc
Autor:
Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen R Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk
Publikováno v:
eLife, Vol 5 (2016)
The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there fir
Externí odkaz:
https://doaj.org/article/6984fb5071a4478b8cce115a8801a2ad
Autor:
João F Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric Simillion, Carole J Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B L Kirkwood, Thomas von Zglinicki
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-14 (2010)
Abstract Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism. The pathways leadin
Externí odkaz:
https://doaj.org/article/c7825abd71494da28dc87edfd7c598df
Autor:
Conor Lawless, Diana Jurk, Colin S Gillespie, Daryl Shanley, Gabriele Saretzki, Thomas von Zglinicki, João F Passos
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32117 (2012)
Increases in cellular Reactive Oxygen Species (ROS) concentration with age have been observed repeatedly in mammalian tissues. Concomitant increases in the proportion of replicatively senescent cells in ageing mammalian tissues have also been observe
Externí odkaz:
https://doaj.org/article/1da9c1db86c8410ebf20ad1c829a70db
Autor:
João F Passos, Gabriele Saretzki, Shaheda Ahmed, Glyn Nelson, Torsten Richter, Heiko Peters, Ilka Wappler, Matthew J Birket, Graham Harold, Karin Schaeuble, Mark A Birch-Machin, Thomas B L Kirkwood, Thomas von Zglinicki
Publikováno v:
PLoS Biology, Vol 5, Iss 5, p e110 (2007)
Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical environments. The replicative lifespan of primary human cells is telomere dependent; however, its he
Externí odkaz:
https://doaj.org/article/0dd6ed23b3284a848c8726777790a6a1
Autor:
Arbi Aghali, Latifa Khalfaoui, Anthony B. Lagnado, Li Y. Drake, Jacob J. Teske, Christina M. Pabelick, João F. Passos, Y. S. Prakash
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(5)
Senescent cells can drive age-related tissue dysfunction partially via a senescence-associated secretory phenotype (SASP) involving proinflammatory and profibrotic factors. Cellular senescence has been associated with a structural and functional decl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb8d17f8892ed852d9050beb788b39c
https://pubmed.ncbi.nlm.nih.gov/36166734
https://pubmed.ncbi.nlm.nih.gov/36166734
Publikováno v:
Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::363b09de593e640a15aa080db24407b7
https://doi.org/10.1097/hep.0000000000000426
https://doi.org/10.1097/hep.0000000000000426
Autor:
Saranya P. Wyles, Parisa Dashti, Tamar Pirtskhalava, Burak Tekin, Christina Inman, Lilian Sales Gomez, Anthony B. Lagnado, Larissa Prata, Diana Jurk, João F. Passos, Tamar Tchkonia, James L. Kirkland
Publikováno v:
Aging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5fee9de2c3a0af23e76900d4b6c9c0
https://doi.org/10.18632/aging.204667
https://doi.org/10.18632/aging.204667
Autor:
Joshua N. Farr, Dominik Saul, Madison L. Doolittle, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Mitchell N. Froemming, Anthony B. Lagnado, Yi Zhu, Megan Weivoda, Yuji Ikeno, Robert J. Pignolo, Laura J. Niedernhofer, Paul D. Robbins, Diana Jurk, João F. Passos, Nathan K. LeBrasseur, Tamara Tchkonia, James L. Kirkland, David G. Monroe, Sundeep Khosla
Publikováno v:
Journal of Clinical Investigation. 133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f342c83072b92f5542c0a2298b4b0ef7
https://doi.org/10.1172/jci162519
https://doi.org/10.1172/jci162519
Autor:
Hélène Martini, João F. Passos
Publikováno v:
The FEBS Journal. 290:1186-1202
Senescence is a multi-functional cell fate, characterized by an irreversible cell-cycle arrest and a pro-inflammatory phenotype, commonly known as the senescence-associated secretory phenotype (SASP). Emerging evidence indicates that accumulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7ce3793fb98c7a89e93b3beb1a2c92
https://doi.org/10.1111/febs.16361
https://doi.org/10.1111/febs.16361