Zobrazeno 1 - 10
of 179
pro vyhledávání: '"João F Passos"'
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Autor:
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle, Xu Zhang, Nathan K. LeBrasseur, Robert J. Pignolo, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Diana Jurk, João F. Passos, LaTonya J. Hickson, Ailing Xue, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Joshua N. Farr, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.
Externí odkaz:
https://doaj.org/article/e07e402c5be742719a9abae3ab241ab2
Autor:
Joshua N. Farr, Dominik Saul, Madison L. Doolittle, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Mitchell N. Froemming, Anthony B. Lagnado, Yi Zhu, Megan Weivoda, Yuji Ikeno, Robert J. Pignolo, Laura J. Niedernhofer, Paul D. Robbins, Diana Jurk, João F. Passos, Nathan K. LeBrasseur, Tamara Tchkonia, James L. Kirkland, David G. Monroe, Sundeep Khosla
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) th
Externí odkaz:
https://doaj.org/article/fc80a778d0594c49a7d28805675dc1fe
Autor:
Jasper Iske, Midas Seyda, Timm Heinbokel, Ryoichi Maenosono, Koichiro Minami, Yeqi Nian, Markus Quante, Christine S. Falk, Haruhito Azuma, Friederike Martin, João F. Passos, Claus U. Niemann, Tamara Tchkonia, James L. Kirkland, Abdallah Elkhal, Stefan G. Tullius
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduc
Externí odkaz:
https://doaj.org/article/2a2a4da6a7984ebfa0d0c386e1408c60
Autor:
LaTonya J. Hickson, Larissa G.P. Langhi Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh K. Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella G. Victorelli, Tammie L. Volkman, Ailing Xue, Mark A. Wentworth, Erin O. Wissler Gerdes, Yi Zhu, Tamara Tchkonia, James L. Kirkland
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 446-456 (2019)
Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including
Externí odkaz:
https://doaj.org/article/0d43e885c44b49ce9dfa80c8a91636b9
Autor:
Branca I. Pereira, Oliver P. Devine, Milica Vukmanovic-Stejic, Emma S. Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J. Sebire, Veronica Kinsler, Alexis Valdovinos, Claude Jourdan LeSaux, João F. Passos, Antony Antoniou, Malcom H. A. Rustin, Judith Campisi, Arne N. Akbar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell acti
Externí odkaz:
https://doaj.org/article/a849def66981451db25ae5092d6b7804
Autor:
Susrutha Puthanmadhom Narayanan, Daniel O’Brien, Mayank Sharma, Karl Miller, Peter Adams, João F. Passos, Alfonso Eirin, Tamas Ordog, Adil E. Bharucha
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Hindered by a limited understanding of the mechanisms responsible for diabetic gastroenteropathy (DGE), management is symptomatic. We investigated the duodenal mucosal expression of protein-coding genes and microRNAs (miRNA) in DGE and related them t
Externí odkaz:
https://doaj.org/article/1d4880925d9d4f0daf293edba44e7d45
Autor:
Arbi Aghali, Latifa Khalfaoui, Anthony B. Lagnado, Li Y. Drake, Jacob J. Teske, Christina M. Pabelick, João F. Passos, Y. S. Prakash
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(5)
Senescent cells can drive age-related tissue dysfunction partially via a senescence-associated secretory phenotype (SASP) involving proinflammatory and profibrotic factors. Cellular senescence has been associated with a structural and functional decl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb8d17f8892ed852d9050beb788b39c
https://pubmed.ncbi.nlm.nih.gov/36166734
https://pubmed.ncbi.nlm.nih.gov/36166734
Autor:
Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen Richard Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/6b2cf351d8cb4f19aed05575781ae9dc
Autor:
LaTonya J. Hickson, Larissa G.P. Langhi Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh K. Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella G. Victorelli, Tammie L. Volkman, Ailing Xue, Mark A. Wentworth, Erin O. Wissler Gerdes, David B. Allison, Stephanie L. Dickinson, Keisuke Ejima, Elizabeth J. Atkinson, Marc Lenburg, Yi Zhu, Tamara Tchkonia, James L. Kirkland
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/9ed50bb390cb426aa207a5f49e49f8fb
Autor:
Stella Victorelli, João F. Passos
Publikováno v:
EBioMedicine, Vol 21, Iss C, Pp 14-20 (2017)
Telomeres are protective structures present at the ends of linear chromosomes that are important in preventing genome instability. Telomeres shorten as a result of cellular replication, leading to a permanent cell cycle arrest, also known as replicat
Externí odkaz:
https://doaj.org/article/fc17c863b9c14ca9bfcfda8023807bb2