Zobrazeno 1 - 8 of 8 pro vyhledávání: '"João D Seixas"'
1
Akademický článek
Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods.
Autor: Hélia F Jeremias, Diana Lousa, Axel Hollmann, Ana C Coelho, Carla S Baltazar, João D Seixas, Ana R Marques, Nuno C Santos, Carlos C Romão, Cláudio M Soares
Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0204624 (2018)
Therapy with inhaled carbon monoxide (CO) is being tested in human clinical trials, yet the alternative use of prodrugs, CO-Releasing Molecules (CORMs), is conceptually advantageous. These molecules are designed to release carbon monoxide in specific
Externí odkaz: https://doaj.org/article/34c99c44fce44562a9ea5278f32c74b8
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2
Akademický článek
Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.
Autor: Rosario Diaz, Sandra A Luengo-Arratta, João D Seixas, Emanuele Amata, William Devine, Carlos Cordon-Obras, Domingo I Rojas-Barros, Elena Jimenez, Fatima Ortega, Sabrinia Crouch, Gonzalo Colmenarejo, Jose Maria Fiandor, Jose Julio Martin, Manuela Berlanga, Silvia Gonzalez, Pilar Manzano, Miguel Navarro, Michael P Pollastri
Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 10, p e3253 (2014)
In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screening collection was pe
Externí odkaz: https://doaj.org/article/ea801c360d7c4780a126030ea3922d0e
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3
Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression
Autor: Tia C L, Kohs, Sven R, Olson, Jiaqing, Pang, Kelley R, Jordan, Tony J, Zheng, Aris, Xie, James, Hodovan, Matthew, Muller, Carrie, McArthur, Jennifer, Johnson, Bárbara B, Sousa, Michael, Wallisch, Paul, Kievit, Joseph E, Aslan, João D, Seixas, Gonçalo J L, Bernardes, Monica T, Hinds, Jonathan R, Lindner, Owen J T, McCarty, Cristina, Puy, Joseph J, Shatzel
Publikováno v: Cell Mol Bioeng
INTRODUCTION: Inflammatory activation of the vascular endothelium leads to overexpression of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), contributing to the pro-thrombotic state underpinning atherogenesis. While the role of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::629673dc47069dbf841dd7a194fa529e
https://pubmed.ncbi.nlm.nih.gov/35611166
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4
A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening
Autor: Bárbara B, Sousa, Marcos F Q, Sousa, Marta C, Marques, João D, Seixas, José A, Brito, Pedro M, Matias, Gonçalo J L, Bernardes, António, Roldão
Publikováno v: Bioprocess and biosystems engineering. 44(1)
Bone Marrow Tyrosine kinase in the chromosome X (BMX) is a TEC family kinase associated with numerous pathological pathways in cancer cells. Covalent inhibition of BMX activity holds promise as a therapeutic approach against cancer. To screen for pot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fd48723e2add770f3f59a9c467f713c
https://pubmed.ncbi.nlm.nih.gov/32816073
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5
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
Autor: Ana Lemos, Marta C. Marques, Shelby K. Doyle, Angela N. Koehler, Di Wu, Rui Traquete, Bárbara B. Sousa, Inês S. Albuquerque, Gonçalo J. L. Bernardes, João D Seixas, Ana Guerreiro, Francisco Corzana, Carol V. Robinson, Tiago M. Bandeiras, Tiago Rodrigues, Marcos F. Q. Sousa, Pedro M. F. Sousa, Pedro M. Matias
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
RSC Chemical Biology
'RSC Chemical Biology ', vol: 1, pages: 251-262 (2020)
This journal is © The Royal Society of Chemistry 2020.
The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with singl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0112212e065374ecc5739886d4f4e98a
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6
Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign
Autor: Pilar Manzano, Silvia Gonzalez, Elena Jimenez, Rosario Diaz, Sandra A. Luengo-Arratta, Domingo I. Rojas-Barros, Miguel Navarro, William G. Devine, Carlos Cordon-Obras, João D. Seixas, Manuela Berlanga, Michael P. Pollastri, Jose M. Fiandor, Emanuele Amata, Gonzalo Colmenarejo, Fátima Ortega, Jose Julio Martin, Sabrinia D. Crouch
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 8, Iss 10, p e3253 (2014)
© 2014 Diaz et al. In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screeni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a2886840f80d788604632bd508d78d
http://hdl.handle.net/10261/111252
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