On the inference of complex phylogenetic networks by Markov Chain Monte-Carlo.

Autor: Charles-Elie Rabier, Vincent Berry, Marnus Stoltz, João D Santos, Wensheng Wang, Jean-Christophe Glaszmann, Fabio Pardi, Celine Scornavacca

Publikováno v: PLoS Computational Biology, Vol 17, Iss 9, p e1008380 (2021)

For various species, high quality sequences and complete genomes are nowadays available for many individuals. This makes data analysis challenging, as methods need not only to be accurate, but also time efficient given the tremendous amount of data t

Externí odkaz: https://doaj.org/article/98f4faaef9124aaabff69bd651787efe

Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum

Autor: João D. Santos, Sara Canato, Ana S. Carvalho, Hugo M. Botelho, Kerman Aloria, Margarida D. Amaral, Rune Matthiesen, Andre O. Falcao, Carlos M. Farinha

Publikováno v: Cells, Vol 8, Iss 4, p 353 (2019)

The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention and early degradation. It is

Externí odkaz: https://doaj.org/article/8c742a672b6c4bb389c4e071889ff2bf

Evolutionary Processes Involved in the Emergence and Expansion of an Atypical O. sativa Group in Madagascar

Autor: João D. Santos, Julien Frouin, Nourollah Ahmadi, Alain Ramanantsoanirina, Tendro Radanielina

Publikováno v: Rice
Rice, Springer Open, 2021, 14 (1), ⟨10.1186/s12284-021-00479-8⟩
Rice, Vol 14, Iss 1, Pp 1-18 (2021)

Understanding crops genetic diversity and the evolutionary processes that accompanied their world-wide spread is useful for designing effective breeding strategies. Madagascar Island was one of the last major Old World areas where human settlement wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b32705e4540ccc9737967b735646a0
https://hal.inrae.fr/hal-03263132

Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe

Autor: João D. G. Correia, João D. Santos, Bruno L. Oliveira, Vera F. C. Ferreira, Carlos M. Farinha, Filipa Mendes

Publikováno v: ChemMedChem. 13:1469-1478

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the CF transmembrane conductance regulator (CFTR) protein. The most common mutation, F508del, leads to almost total absence of CFTR at the plasma membrane, a defect potentially corr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50eb93abe4890aecbe47e747b0287b22
https://doi.org/10.1002/cmdc.201800187

Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum

Autor: Kerman Aloria, Margarida D. Amaral, Carlos M. Farinha, João D. Santos, André O. Falcão, Ana Sofia Carvalho, Rune Matthiesen, Sara Canato, Hugo M. Botelho

Publikováno v: Cells
Volume 8
Issue 4
Addi. Archivo Digital para la Docencia y la Investigación
instname
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cells, Vol 8, Iss 4, p 353 (2019)

The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention and early degradation. It is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8639e8107f599914ad28a978da41e060