Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma.

Autor: Maria J Camões, Paula Paulo, Franclim R Ribeiro, João D Barros-Silva, Mafalda Almeida, Vera L Costa, Nuno Cerveira, Rolf I Skotheim, Ragnhild A Lothe, Rui Henrique, Carmen Jerónimo, Manuel R Teixeira

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49819 (2012)

FLI1 and ERG, the major ETS transcription factors involved in rearrangements in the Ewing's sarcoma family of tumors (ESFT) and in prostate carcinomas (PCa), respectively, belong to the same subfamily, having 98% sequence identity in the DNA binding

Externí odkaz: https://doaj.org/article/3f287445533d4b2a9279c0c11708fc2d

Patient derived organoids reveal that PI3K/AKT signalling is an escape pathway for radioresistance and a target for therapy in rectal cancer

Autor: Celina Whalley, Andrew D Beggs, Oliver J Pickles, Rachel Hoare, Kasun Wanigasooriya, Tortieju Sillo, Mohammed E. El-Asrag, Robert Tyler, Louise Tee, Tariq Ismail, João D. Barros-Silva, Agata Stodolna, Joanne D. Stockton, Christopher Yau, Claire Bryer

Partial or total resistance to preoperative chemoradiotherapy occurs in more than half of locally advanced rectal cancer patients. Several novel or repurposed drugs have been trialled to improve cancer cell sensitivity to radiotherapy, with limited s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30f360ef6663cfb090a839265b85f193
https://doi.org/10.1101/2021.08.31.458326

Radiosensitising Cancer Using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or Mammalian Target of Rapamycin (mTOR) Inhibitors

Autor: Robert Tyler, Tariq Ismail, Andrew D Beggs, Kasun Wanigasooriya, João D. Barros-Silva, Yashashwi Sinha

Publikováno v: Cancers, Vol 12, Iss 1278, p 1278 (2020)
Cancers

Radiotherapy is routinely used as a neoadjuvant, adjuvant or palliative treatment in various cancers. There is significant variation in clinical response to radiotherapy with or without traditional chemotherapy. Patients with a good response to radio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32a82a87a5b68a4d88140612380d9bf
https://www.mdpi.com/2072-6694/12/5/1278

Prostate Cancer Prognosis Defined by the Combined Analysis of 8q, PTEN and ERG

Autor: Tarjei S. Hveem, Manuel R. Teixeira, Maria P. Silva, Joana Vieira, Elin Ersvær, Håvard E. Danielsen, Manohar Pradhan, Wanja Kildal, João D. Barros-Silva

Publikováno v: Translational Oncology. 9:575-582

Overtreatment is a major concern in men diagnosed with prostate cancer. The aim of this study was to evaluate the combined prognostic role of three frequent molecular alterations in prostate cancer, namely relative 8q gain, ERG overexpression, and lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ca382911ea51ebd81389518d0eb009
https://doi.org/10.1016/j.tranon.2016.08.005

Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer

Autor: Noel W. Clarke, Esther Baena, Guo-Cheng Yuan, Ivana Steiner, Douglas E. Linn, Garry Ashton, Hubert Pakula, Isabel Peset, Roderick T. Bronson, Zhe Li, Stuart H. Orkin, Adnan Ali, Guoji Guo, João D. Barros-Silva, Michael D Brown

Publikováno v: Barros-Silva, J D, Linn, D E, Steiner, I, Guo, G, Ali, A, Pakula, H, Ashton, G, Peset, I, Brown, M, Clarke, N W, Bronson, R T, Yuan, G-C, Orkin, S H, Li, Z & Baena, E 2018, ' Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer ', Cell Reports, vol. 25, no. 12, pp. 3504-3518.e6 . https://doi.org/10.1016/j.celrep.2018.11.069
Cell Reports
Cell Reports, Vol 25, Iss 12, Pp 3504-3518.e6 (2018)

Summary The exact identity of castrate-resistant (CR) cells and their relation to CR prostate cancer (CRPC) is unresolved. We use single-cell gene profiling to analyze the molecular heterogeneity in basal and luminal compartments. Within the luminal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973d65a8592483a3258d28e0348b6ae7
https://doi.org/10.1016/j.celrep.2018.11.069