Zobrazeno 1 - 10
of 3 515
pro vyhledávání: '"João D"'
Autor:
Mário F. Munoz-Pinto, Emanuel Candeias, Inês Melo-Marques, A. Raquel Esteves, Ana Maranha, João D. Magalhães, Diogo Reis Carneiro, Mariana Sant’Anna, A. Raquel Pereira-Santos, António E Abreu, Daniela Nunes-Costa, Susana Alarico, Igor Tiago, Ana Morgadinho, João Lemos, Pedro N. Figueiredo, Cristina Januário, Nuno Empadinhas, Sandra Morais Cardoso
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-28 (2024)
Abstract Background In Parkinson's patients, intestinal dysbiosis can occur years before clinical diagnosis, implicating the gut and its microbiota in the disease. Recent evidence suggests the gut microbiota may trigger body-first Parkinson Disease (
Externí odkaz:
https://doaj.org/article/cc48bbbb0e4a41628cd2260dc44bdf1c
Publikováno v:
Nuclear Engineering and Technology, Vol 56, Iss 12, Pp 4983-4996 (2024)
Monitoring the radial power distribution during the operation of a pressurized light water reactor (PWR) is crucial for ensuring safe operating conditions and achieving high levels of fuel burnup. This paper introduces a methodology utilizing Artific
Externí odkaz:
https://doaj.org/article/cabaa123a19d42c486f931b6b54b6216
Autor:
Camila J. Cuellar, Thiago F. Amaral, Paula Rodriguez‐Villamil, F. Ongaratto, D. Onan Martinez, Rémi Labrecque, João D. de Agostini Losano, Eliab Estrada‐Cortés, Jonathan R. Bostrom, Kyra Martins, D. Owen Rae, Jeremy Block, Quinn A. Hoorn, Bradford W. Daigneault, Jonathan Merriam, Michael Lohuis, Serdal Dikmen, João H. J. Bittar, Tatiane S. Maia, Daniel F. Carlson, Sabreena Larson, Tad S. Sonstegard, Peter J. Hansen
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 8, Pp 223-234 (2024)
Abstract Global warming is a major challenge to the sustainable and humane production of food because of the increased risk of livestock to heat stress. Here, the example of the prolactin receptor (PRLR) gene is used to demonstrate how gene editing c
Externí odkaz:
https://doaj.org/article/9c2fdecfd6fc42c2b2aef21505d1da0e
Autor:
Marco Cavaco, Patrícia Fraga, Javier Valle, Ruben D. M. Silva, Lurdes Gano, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Blood–brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are poorly characterized. Currently, their development relies on the e
Externí odkaz:
https://doaj.org/article/ff105247e7514a8eb2dac249aa0d9bfc
Autor:
Ana S. André, Joana N. R. Dias, Sandra Aguiar, Sara Nogueira, Pedro Bule, Joana Inês Carvalho, João P. M. António, Marco Cavaco, Vera Neves, Soraia Oliveira, Gonçalo Vicente, Belmira Carrapiço, Berta São Braz, Barbara Rütgen, Lurdes Gano, João D. G. Correia, Miguel Castanho, Joao Goncalves, Pedro M. P. Gois, Solange Gil, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Antibody–drug conjugates (ADCs) are among the fastest-growing classes of therapeutics in oncology. Although ADCs are in the spotlight, they still present significant engineering challenges. Therefore, there is an urgent need to develop mor
Externí odkaz:
https://doaj.org/article/f9c1a085d74e4cbdaf2217e2c95385f7
Autor:
Ana S. André, Joana N. R. Dias, Sandra I. Aguiar, Ana Leonardo, Sara Nogueira, Joana D. Amaral, Célia Fernandes, Lurdes Gano, João D. G. Correia, Marco Cavaco, Vera Neves, Jorge Correia, Miguel Castanho, Cecília M. P. Rodrigues, Maria Manuela Gaspar, Luís Tavares, Frederico Aires-da-Silva
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
IntroductionCancer is a major public health problem with over 19 million cases reported in 2020. Similarly to humans, dogs are also largely affected by cancer, with non-Hodgkin's lymphoma (NHL) among the most common cancers in both species. Comparati
Externí odkaz:
https://doaj.org/article/e1ae62f371ba4be582f085b5e995f720
Autor:
João D. Semedo, Anna I. Jasper, Amin Zandvakili, Aravind Krishna, Amir Aschner, Christian K. Machens, Adam Kohn, Byron M. Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
How cortical areas interact via feedforward and feedback signaling remains unclear. Here, the authors recorded from V1 and V2/V4 in macaque visual cortex and found that feedforward and feedback interactions vary with stimulus drive and involve differ
Externí odkaz:
https://doaj.org/article/f4a7e8eaff70477eac9c2c2a8e6381b4
Autor:
João D. Nunes, Athanasios Vourvopoulos, Diego Andrés Blanco-Mora, Carolina Jorge, Jean-Claude Fernandes, Sergi Bermudez i Badia, Patrícia Figueiredo
Publikováno v:
PLoS ONE, Vol 18, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/34f36debc12b44f3b6ada9fb91f24d8e
Vision Language Models (VLMs) have demonstrated strong capabilities across various visual understanding and reasoning tasks. However, their real-world deployment is often constrained by high latency during inference due to substantial compute require
Externí odkaz:
http://arxiv.org/abs/2411.03312
Vision-language models (VLMs) such as CLIP are trained via contrastive learning between text and image pairs, resulting in aligned image and text embeddings that are useful for many downstream tasks. A notable drawback of CLIP, however, is that the r
Externí odkaz:
http://arxiv.org/abs/2409.09721