Zobrazeno 1 - 4
of 4
pro vyhledávání: '"João C. M. Mafra"'
Autor:
Daniel T. G. Gonzaga, Felipe H. Oliveira, N. L. von Ranke, G. Q. Pinho, Juliana P. Salles, Murilo L. Bello, Carlos R. Rodrigues, Helena C. Castro, Hellen V. C. M. de Souza, Caroline R. C. Reis, Rennan P. P. Leme, João C. M. Mafra, Luiz C. S. Pinheiro, Lucas V. B. Hoelz, Nubia Boechat, Robson X. Faria
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Twenty new 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole analogs were synthetized to develop P2X7 receptor (P2X7R) inhibitors. P2X7R inhibition in vitro was evaluated in mouse peritoneal macrophages, HEK-293 cells transfected with hP2X7R (dye uptake assay),
Externí odkaz:
https://doaj.org/article/9ab312f8957145ae9c80d75e8662765a
Autor:
Kamilla R. Rogério, João C. M. Mafra, Lívia M. Feitosa, Nubia Boechat, Luiz C. S. Pinheiro, Leonardo J M Carvalho, Flávia F. Silveira, Maria de Lourdes G. Ferreira
Publikováno v:
Medicinal Chemistry Research. 27:1876-1884
Nine 1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives with different substituents in the 4-position of the phenyl group and benzenesulfonamide moiety were synthesized and evaluated against Plasmodium falciparum. Six compounds exhibited activity in v
Publikováno v:
Synthetic Communications. 27:4361-4366
Abstract: Dieckman Cyclization of ethyl adipate (1) mediated by Na or K in toluene, followed by removal of the resulting ethanol, addition of t-BuOH or DMSO and addition of ethyl iodide or n-butyl bromide, led to production of the title compounds (3a
Autor:
Iziara Ferreira Florentino, Antonio C. C. Freitas, Frederico Argollo Vanderlinde, João C. M. Mafra, Raquel Teixeira Ferreira, David do Carmo Malvar, Ligia Lins de Castro, Raphael Andrade de Castro, Elson Alves Costa, Glória Emília Petto de Souza
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Aims Heterocyclic pyrazole derivative has been described for the treatment of pain and inflammatory diseases. This study evaluated the in vivo , antinociceptive, anti-inflammatory and antipyretic effects of 1.5-diphenyl-1 H -Pyrazole-3-carbohydrazide