Clinical oxidative stress during leprosy multidrug therapy: impact of dapsone oxidation.

Autor: Taysa Ribeiro Schalcher, Rosivaldo S Borges, Michael D Coleman, João Batista Júnior, Claudio G Salgado, Jose Luiz F Vieira, Pedro R T Romão, Fabio R Oliveira, Marta Chagas Monteiro

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85712 (2014)

This study aims to assess the oxidative stress in leprosy patients under multidrug therapy (MDT; dapsone, clofazimine and rifampicin), evaluating the nitric oxide (NO) concentration, catalase (CAT) and superoxide dismutase (SOD) activities, glutathio

Externí odkaz: https://doaj.org/article/a750570a33e04e86b1c15fb3a76ff366

Molecular interactions and physico-chemical characterization of quercetin-loaded magnetoliposomes

Autor: Cruz dos Santos, Sandra, Osti Silva, Nichole, dos Santos Espinelli, João Batista, Junior, Germani Marinho, Marcelo Augusto, Vieira Borges, Zeane, Bruzamarello Caon Branco, Natália, Faita, Fabrício Luiz, Meira Soares, Bruno, Horn, Ana Paula, Parize, Alexandre Luís, Rodrigues de Lima, Vânia

Publikováno v: In Chemistry and Physics of Lipids January 2019 218:22-33

Tumor Necrosis Factor Alpha Converting Enzyme (TACE) as Possible Therapeutic Target in SARS-CoV-2 Induced Acute Respiratory Distress Syndrome (ARDS)

Autor: João Batista Júnior

This study reveals, for the first time, that rosiglitazone and pioglitazone, two thiazolidinedione drugs already approved as therapeutic agents to treat type II diabetes, were found to bind favorably to tumor necrosis factor alpha converting enzyme c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2502b764f8b2fdc8d7561b4dc26ab16
https://doi.org/10.26434/chemrxiv.13174415.v1

Simultaneous infection of human host with genetically distinct isolates of Paracoccidioides brasiliensis

Autor: Zoilo Pires de Camargo, Adelita Duanra Medeiros do Monte Arnaud, Rosane Christine Hahn, João Batista Júnior, Cor Jesus Fernandes Fontes, Rodrigo Berzaghi

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 105, Iss 1, Pp 62-65 (2010)
Memórias do Instituto Oswaldo Cruz, Volume: 105, Issue: 1, Pages: 62-65, Published: FEB 2010

This study is the first report on genetic differences between isolates of Paracoccidioides brasiliensis from a single patient. We describe a simultaneous infection with genetically distinct isolates of P. brasiliensis in a patient with chronic paraco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a950d312fd143eb8b815173e7413cf99
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000100009

Genotoxic effects of the antimalarial drug lumefantrine in human lymphocytes in vitro and computational prediction of the mechanism associated with its interaction with DNA

Autor: Renato M R, de Lucca, João, Batista Júnior, Cor J Fernandes, Fontes, Marcelo de Oliveira, Bahia, Carmen L, Bassi-Branco

Publikováno v: Environmental and molecular mutagenesis. 56(6)

Lumefantrine (LF) is an aryl-amino alcohol antimalarial drug used in artemisinin-based combination therapies against malaria worldwide. In this study, we investigated the genotoxic effects of LF in human lymphocytes in vitro, and the potential noncov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd9a9c2d14fe395c075052eb4c46b733
https://pubmed.ncbi.nlm.nih.gov/25821123