Zobrazeno 1 - 10
of 115
pro vyhledávání: '"João B. Relvas"'
Autor:
Sara Costa-Pinto, Joana Gonçalves-Ribeiro, Joana Tedim-Moreira, Renato Socodato, João B. Relvas, Ana M. Sebastião, Sandra H. Vaz
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106435- (2024)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance between excitation and inhibition,
Externí odkaz:
https://doaj.org/article/3d9bf21c7b474c4fb4d5c69222424290
Autor:
Renato Socodato, Artur Rodrigues-Santos, Joana Tedim-Moreira, Tiago O. Almeida, Teresa Canedo, Camila C. Portugal, João B. Relvas
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-15 (2023)
Abstract Microglia are the largest myeloid cell population in the brain. During injury, disease, or inflammation, microglia adopt different functional states primarily involved in restoring brain homeostasis. However, sustained or exacerbated microgl
Externí odkaz:
https://doaj.org/article/3994b4d2fd7c4a6cbc6d01adeccdeaee
Autor:
Renato Socodato, Tiago O. Almeida, Camila C. Portugal, Evelyn C.S. Santos, Joana Tedim-Moreira, João Galvão-Ferreira, Teresa Canedo, Filipa I. Baptista, Ana Magalhães, António F. Ambrósio, Cord Brakebusch, Boris Rubinstein, Irina S. Moreira, Teresa Summavielle, Inês Mendes Pinto, João B. Relvas
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113447- (2023)
Summary: Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate th
Externí odkaz:
https://doaj.org/article/914f35ba494042d8aa265dd02cbdf0a4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/edd5148a59a5450f9dcc6e5e302e0912
Autor:
Renato Socodato, Artur Rodrigues-Santos, Joana Tedim-Moreira, Tiago O. Almeida, Teresa Canedo, Camila C. Portugal, João B. Relvas
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/cd49438762284808bc57043927df0d87
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100147- (2020)
Summary: This protocol highlights the use of FRET-based biosensors to investigate signaling events during microglia activation in real time. Understanding microglia activation has gained momentum as it can help decipher signaling mechanisms underlyin
Externí odkaz:
https://doaj.org/article/9392919725ab448d90ed76cf3fce0ef3
Autor:
Alexandra Plácido, João Bueno, Eder A. Barbosa, Daniel C. Moreira, Jhones do Nascimento Dias, Wanessa Felix Cabral, Patrícia Albuquerque, Lucinda J. Bessa, Jaime Freitas, Selma A. S. Kuckelhaus, Filipe C. D. A. Lima, Augusto Batagin-Neto, Guilherme D. Brand, João B. Relvas, José Roberto S. A. Leite, Peter Eaton
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 512 (2020)
Amphibian skin is a multifunctional organ that plays key roles in defense, breathing, and water balance. In this study, skin secretion samples of the fire salamander (Salamandra salamandra) were separated using RP-HPLC and de novo sequenced using MAL
Externí odkaz:
https://doaj.org/article/706eb5c968b6477c8822ee2229ecb47e
Autor:
Catarina M. Abreu, Ricardo Soares-dos-Reis, Pedro N. Melo, João B. Relvas, Joana Guimarães, Maria José Sá, Andrea P. Cruz, Inês Mendes Pinto
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Neuroinflammation plays a critical role in the onset and progression of many neurological disorders, including Multiple Sclerosis, Alzheimer's and Parkinson's diseases. In these clinical conditions the underlying neuroinflammatory processes are signi
Externí odkaz:
https://doaj.org/article/2a214eb7b4614ef49520c3a74a18978b
Autor:
Renato Socodato, João B. Relvas
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 7, Pp 1989-1990 (2025)
Externí odkaz:
https://doaj.org/article/96b103dc946f4363a7236bc7246cb656
Autor:
Patrícia D. Correia, Bárbara M. de Sousa, Jesús Chato-Astrain, Joana P. Faria, Veronica Estrada, João B. Relvas, Hans W. Müller, Víctor Carriel, Frank Bosse, Sandra I. Vieira
Contrary to the adult central nervous system (CNS), the peripheral nervous system (PNS) has an intrinsic ability to regenerate that, among others, passes by expressing regeneration-associated genes such as kinesin family members. We here show that Ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::205f8116bdd6d5caca734f41b81c1336
https://doi.org/10.1101/2023.05.21.541636
https://doi.org/10.1101/2023.05.21.541636