Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy

Autor: Jeon, Min Jae, Lee, Hyelim, Jo, Seongman, Kang, Miso, Jeong, Jeong Hyun, Jeong, So Hyeon, Lee, Joo-Youn, Song, Gyu Yong, Choo, Hyunah, Lee, Sanghee, Kim, Hyejin

Publikováno v: In European Journal of Medicinal Chemistry 5 December 2023 261

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Development of Small-Molecule STING Activators for Cancer Immunotherapy.

Autor: Jung HR; Creative Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea., Jo S; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea.; Department of Pharmacy, College of Pharmacy, Chungnam National University, Daejeon 34134, Korea., Jeon MJ; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea.; Department of Medicinal Chemistry and Pharmacology, University of Science & Technology, Daejeon 34113, Korea., Lee H; Creative Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.; Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea., Chu Y; Creative Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea., Lee J; Creative Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.; Department of HY-KIST Bio-Convergence, Hanyang University, Seoul 04763, Korea., Kim E; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea., Song GY; Department of Pharmacy, College of Pharmacy, Chungnam National University, Daejeon 34134, Korea., Jung C; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea., Kim H; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea., Lee S; Creative Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.; Department of HY-KIST Bio-Convergence, Hanyang University, Seoul 04763, Korea.

Publikováno v: Biomedicines [Biomedicines] 2021 Dec 24; Vol. 10 (1). Date of Electronic Publication: 2021 Dec 24.