Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jnan R. Saha"'
Publikováno v:
Gastroenterology. 95:117-123
Digoxin is metabolized to cardioinactive reduced metabolites (digoxin reduction products) in some patients by anaerobic bacteria present in the gut flora. We compared the tendencies of Americans and Bangladeshis to reduce digoxin by this pathway. Of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a214c959c8e6c566303faa80481b5e
https://doi.org/10.1016/0016-5085(88)90299-5
https://doi.org/10.1016/0016-5085(88)90299-5
Publikováno v:
New England Journal of Medicine. 305:789-794
In approximately 10 per cent of patients given digoxin, substantial conversion of the drug to cardioinactive, reduced metabolites (digoxin reduction products, or DRPs) occurs. The site and clinical importance of this conversion is unknown. In four no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b05e007d6ec76352af8a84502262c1
https://doi.org/10.1056/nejm198110013051403
https://doi.org/10.1056/nejm198110013051403
Autor:
Jay F. Dobkin, Vincent P. Butler, Jnan R. Saha, John Lindenbaum, Linda Linday, Timothy C. Wang
Publikováno v:
Pediatrics. 79:544-548
Inactivation of digoxin by reduction of the lactone ring has recently been shown to occur in one third of adults and to be mediated by anaerobic intestinal bacteria. Children from birth through adolescence were studied to determine the pattern of dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5833fbfa598a83131fb921cea993ccba
https://doi.org/10.1542/peds.79.4.544
https://doi.org/10.1542/peds.79.4.544
Publikováno v:
Clinical Pharmacology and Therapeutics. 34:738-743
The generation by intestinal bacteria of large amounts of cardioinactive metabolites of digoxin with a reduced lactone ring (digoxin reduction products, or DRP) may be associated with increased dosage requirements. Since DRP excretion varies inversel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba4bcc50429e90f49556da5f095e5b1
https://doi.org/10.1038/clpt.1983.243
https://doi.org/10.1038/clpt.1983.243
Publikováno v:
Annals of internal medicine. 75(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98228c1d55a1db3e04681e24e9e74496
https://pubmed.ncbi.nlm.nih.gov/5091566
https://pubmed.ncbi.nlm.nih.gov/5091566