Effect of Hypothermia on the Hepatic Uptake and Biliary Excretion of Vecuronium in the Isolated Perfused Rat Liver

Autor: Jmkh Wierda, Dirk K. F. Meijer, T. M. Beaufort, JG Maring, ER Scheffer, Johannes H. Proost

Publikováno v: Anesthesiology. 94:270-279

Background Hypothermia prolongs the time course of action of nondepolarizing muscle relaxants. It is not known whether this prolongation is caused by a reduced rate of extrahepatic distribution or elimination, liver uptake, metabolic clearance, or bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f55efdf267891e93c2136736878fec
https://doi.org/10.1097/00000542-200102000-00017

[Untitled]

Autor: [No Value] Fidler, Jmkh Wierda, G. Van Santen

Publikováno v: Journal of Clinical Monitoring and Computing. 15:263-269

Objective. To determine whether the twitch force of the adductor pollicis remains stable when 0.1 Hz single twitch stimulation is started after stabilization of the thumb preload at a constant degree of thumb abduction; also to study any possible inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae697d9e617c656de0714b5e5718cec
https://doi.org/10.1023/a:1009950609418

Preliminary investigations of the clinical pharmacology of three short-acting non-depolarizing neuromuscular blocking agents, Org 9453, Org 9489 and Org 9487

Autor: A. M. Beaufort, Sandor Agoston, N. J. Smeulers, Jmkh Wierda, U. W. Kleef

Publikováno v: Canadian Journal of Anaesthesia. 41:213-220

Three muscle relaxants, Org 9453, Org 9489 and Org 9487, short-acting in animals, were investigated to establish their profiles in humans. Potency, time course of action, and pharmacokinetic behaviour were studied in 90 healthy patients during fentan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f24f1e0902681c9990d6243335f5a62
https://doi.org/10.1007/bf03009833

Improving pharmacokinetic-pharmacodynamic models of muscle relaxants using potentiation modelling

Autor: Jmkh Wierda, A De Haes, Johannes H. Proost, Douglas J. Eleveld

Publikováno v: Journal of pharmacokinetics and pharmacodynamics, 32(1), 143-154. SPRINGER/PLENUM PUBLISHERS

Repeated motor nerve stimulation performed during neuromuscular monitoring enhances the evoked mechanical response of the corresponding muscle resulting in an increased twitch response. This is known as twitch potentiation or the staircase phenomenon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7051a0889cb9739ad17b3db5165749
https://research.rug.nl/en/publications/eedf6b6a-feea-4f51-ad6d-27844324ce46

Prevention of hypotension after induction of anesthesia after preoperative tune-up. A preliminary report of the Groningen tune-up study

Autor: Jmkh Wierda, Arj Girbes, J. J. M. Ligtenberg, Jpc Sonneveld

Publikováno v: Netherlands Journal of Medicine, 54(6), 215-220. Van Zuiden Communications BV
Girbes, A R J, Ligtenberg, J J M, Sonneveld, J P C & Wierda, J M K H 1999, ' Prevention of hypotension after induction of anesthesia after preoperative tune-up. A preliminary report of the Groningen tune-up study ', Netherlands Journal of Medicine, vol. 54, no. 6, pp. 215-220 . https://doi.org/10.1016/S0300-2977(98)00142-9
Netherlands Journal of Medicine, 54(6), 215-220. van Zuiden Communications BV.

Objective: To investigate whether the frequently occurring hypotension after induction of anesthesia can be prevented by preoperative treatment at the ICU guided by hemodynamic data obtained from a pulmonary artery (PA) catheter. Design: Prospective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8355431fa904b0f75fb8feb2c28b21
https://research.vumc.nl/en/publications/ae8167e7-e549-4957-9bf3-0bf856fab09e