Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jmc Connell"'
Autor:
Jmc Connell, J Pembroke, John Webster, Jo Knight, Martin Farrall, David Clayton, Nick J.R. Brain, Nigel Benjamin, Patricia B. Munroe, Mark Lathrop, Wai K. Lee, Nilesh J. Samani, Mark J. Caulfield, Anna F. Dominiczak, Matthew A. Brown, Peter J. Ratcliffe
Publikováno v:
Angiología. 67:304-311
Resumen The American College of Cardiology y la American Heart Association (ACC/AHA) publicaron hace unos meses (noviembre 2013) una nueva guia de practica clinica para el tratamiento de la hipercolesterolemia en pacientes del alto riesgo de enfermed
Autor:
Stephen Miller, G. H. Forbes, M Barr, Jmc Connell, R. Fraser, Scott M. MacKenzie, C Holloway, D Wilkinson, E Friel, Eleanor Davies
Publikováno v:
Clinical Endocrinology. 70:363-371
Summary Objective Evidence suggests that high levels of aldosterone lead to hypertension and increased risk of cardiovascular disease. Around 15% of patients with essential hypertension have a raised aldosterone to renin ratio (ARR) suggesting that a
Autor:
Jmc Connell, Theodore D. Mountokalakis, George S. Stergiou, Gordon T. McInnes, G C Inglis, Stamatis P. Efstathiou
Publikováno v:
Journal of Human Hypertension. 19:971-974
Association of renin–angiotensin system gene polymorphisms with antihypertensive responses to angiotensin-converting enzyme inhibition or angiotensin receptor blockade
Autor:
Bernard Keavney, M Baker, N Gaukrodger, Peter Avery, Jmc Connell, Bongani M. Mayosi, Hugh Watkins, Helen Imrie, Martin Farrall
Publikováno v:
Journal of Medical Genetics. 42:474-478
Background: Rare mutations in the leptin ( LEP ) gene cause severe obesity. Common polymorphisms of LEP have been associated with obesity, but their association with cardiovascular disease has been little studied. We have examined the impact of both
Autor:
Jmc Connell, Declan J. James, Gwyn W. Gould, Anna F. Dominiczak, D. I. Graham, Ian P. Salt, M. Collison, Geoffrey D. Holman
Publikováno v:
Diabetologia. 48:539-546
Insulin-stimulated glucose transport is impaired in a genetic model of hypertension, the stroke-prone spontaneously hypertensive rat (SHRSP), yet the molecular mechanisms that underlie this defect in the animals remain unclear.We examined the effects
Publikováno v:
Clinical Endocrinology. 61:149-154
Summary objective The precise interactions between glucocorticoids and leptin are complex and poorly understood. The aim of the study was to investigate whether the glucocorticoid/leptin interaction is influenced by shared environmental or genetic fa
Publikováno v:
Scottish medical journal. 52(4)
Hypertension is a common condition affecting one in four adults. It is a leading cause of cardiovascular morbidity and mortality and appropriate treatment strategies that are both clinically and cost effective are key to the management of this condit
Autor:
Nilesh J. Samani, David Clayton, Ellen Marie Freel, Eleanor Davies, E Friel, Mark J. Caulfield, Jmc Connell, Mary C. Ingram, John Webster, R. Fraser, Anna F. Dominiczak, Matthew A. Brown, Patricia B. Munroe, Martin Farrall
Publikováno v:
Clinical endocrinology. 67(6)
BACKGROUND: Aldosterone is an important cardiovascular hormone; 15% of hypertensive subjects have alteration in aldosterone regulation, defined by a raised ratio of aldosterone to renin (ARR). Studies of the aldosterone synthase gene (CYP11B2) have f
Autor:
Anne White, Ellen Marie Freel, Jmc Connell, A. M. Wallace, Mary C. Ingram, Eleanor Davies, R. Fraser
Publikováno v:
Clinical endocrinology. 68(5)
BACKGROUND: Aldosterone is important in the development of hypertension. We have shown that a single nucleotide polymorphism (SNP) (-344T) in the 5' regulatory region (UTR) of the gene encoding aldosterone synthase (CYP11B2) associates with aldostero
Publikováno v:
Clinical endocrinology. 66(6)
The best method for determining hydrocortisone replacement therapy is not well defined. This study aimed to assess interindividual variability in cortisol pharmacokinetics and to investigate whether measurement of salivary cortisol provides a useful