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Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells

Autor: Mc, Tan, Am, Mommaas, Jw, Drijfhout, Jordens R, Jj, Onderwater, Verwoerd D, Aa, Mulder, An, Heiden, Th, Ottenhoff, Marina Cella, Tulp A, Jj, Neefjes, Koning F

Publikováno v: Europe PubMed Central

Dendritic cells (DCs) use macropinocytosis and mannose receptor mediated endocytosis for the uptake of exogenous antigens. Here we show that the endocytosis of the mannose receptor and mannosylated antigen is distinct from that of a non-mannosylated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2530902a04feb23d7b276bf4ec24f85f
https://pubmed.ncbi.nlm.nih.gov/9286356

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Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences

Autor: Neisig A, Roelse J, Alice Sijts, Ossendorp F, Mc, Feltkamp, Wm, Kast, Cj, Melief, Jj, Neefjes

Publikováno v: Europe PubMed Central

The MHC-encoded transporter associated with Ag presentation (TAP) translocates peptides from the cytosol to the ER lumen, where association with MHC class I molecules occurs. The MHC class I/peptide complex is subsequently transported to the cell sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::62320692635304c60d7e2076e67afa58
https://pubmed.ncbi.nlm.nih.gov/7822796

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