Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Jiyue Zheng"'
Autor:
Xiaoou Hou, Yuqing Yuan, Yulan Sheng, Baoshi Yuan, Yali Wang, Jiyue Zheng, Chun-Feng Liu, Xiaohu Zhang, Li-Fang Hu
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
The neuromodulator hydrogen sulfide (H2S) was shown to exert neuroprotection in different models of Parkinson’s disease (PD) via its anti-inflammatory and anti-apoptotic properties. In this study, we evaluated the effect of an H2S slow-releasing co
Externí odkaz:
https://doaj.org/article/27358f4c8b454b0a8f2404b935731a4b
Autor:
Hu, Jinlong, Gan, Mengyu, Ma, Li, Zhang, Jun, Xie, Shuang, Xu, Fenfang, Shen, JiYue Zheng Xiaoyu, Yin, Hui
Publikováno v:
In Applied Surface Science 15 February 2015 328:325-334
Autor:
Yu Lin, Sheng Tian, Shuwei Wu, Haikuo Ma, Jiyue Zheng, Fang Zhu, Chunyan Fu, Li Zhao, Lusong Luo, Yujie Wang, Shiwei Song, Xu Wang, Zhanhui Li, Sudan He, Xiaohu Zhang
Publikováno v:
ChemMedChem. 15:1150-1162
Chemokine receptor CXCR4 and its natural ligand CXCL12 (also known as stromal cell-derived factor-1, or SDF-1) regulate a broad range of physiological functions. Dysregulation of the CXCL12/CXCR4 axis is involved in numerous pathological conditions s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d2de41734211faaacbaf651e94c6de
https://doi.org/10.1002/cmdc.202000268
https://doi.org/10.1002/cmdc.202000268
The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway
Autor:
Xiaohu Zhang, Jiyue Zheng, Lin Sun, Chaojun Han, Zhong-qiang Cao, Xuechu Zhen, Huicui Yang, Long Tai Zheng
Publikováno v:
Acta Pharmacol Sin
Microglia, the brain-resident macrophage, is known as the innate immune cell type in the central nervous system. Microglia is also the major cellular component of tumor mass of gliomas that plays a key role in glioma development. Mutations of isocitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4653ef63d345405a6b4febeb4846cba
https://doi.org/10.1038/s41401-019-0225-9
https://doi.org/10.1038/s41401-019-0225-9
Autor:
Zhanhui Li, Fang Zhu, Xu Wang, Chen Xu, Haikuo Ma, Sudan He, Shuwei Wu, Yujie Wang, Jiyue Zheng, Xiaohu Zhang, Lusong Luo, Kaijiang Xia, Yu Lin
Publikováno v:
European journal of medicinal chemistry. 205
The chemokine receptor CXCR4 has been proposed as a drug target based on its important functions in HIV infection, inflammation/autoimmune diseases and cancer metastasis. Herein we report the design, synthesis and evaluation of novel CXCR4 antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27bef729929394c132a3e42b17b0879
https://pubmed.ncbi.nlm.nih.gov/32768738
https://pubmed.ncbi.nlm.nih.gov/32768738
Autor:
Xiaohu Zhang, Kaijiang Xia, Zhanhui Li, Shuwei Wu, Qing Yang, Haikuo Ma, Chen Xu, Lusong Luo, Yu Lin, Fang Zhu, Jiyue Zheng, Sudan He, Yongjin Hao
Publikováno v:
Bioorganic chemistry. 99
The chemokine receptor CXCR4 has been explored as a drug target due to its involvement in pathological conditions such as HIV infection and cancer metastasis. Here we report the structure–activity relationship study of novel CXCR4 antagonists based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7269ff8474d3fbd6176a26dc4c184b29
https://pubmed.ncbi.nlm.nih.gov/32334192
https://pubmed.ncbi.nlm.nih.gov/32334192
Publikováno v:
ACS Chemical Neuroscience. 10:783-791
Parkinson’s disease (PD) is a neurodegenerative disease with significant unmet medical needs. The current dopamine-centered treatments aim to restore motor functions of patients without slowing the disease progression. Long-term usage of these drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7e9e3e7df00904da271b8e6a0693fb0
https://doi.org/10.1021/acschemneuro.8b00313
https://doi.org/10.1021/acschemneuro.8b00313
Autor:
Qin Wang, Haikuo Ma, Wenfeng Lu, Xiaohu Zhang, Lusong Luo, Sheng Tian, Dihua Zhang, Jiyue Zheng
Publikováno v:
European Journal of Medicinal Chemistry. 155:34-48
The Hedgehog (Hh) signaling pathway plays a critical role in controlling patterning, growth and cell migration during embryonic development. Aberrant activation of Hh signaling has been linked to tumorigenesis in various cancers, such as basal cell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b021eb34e0461788fc1a7e95864cca
https://doi.org/10.1016/j.ejmech.2018.05.035
https://doi.org/10.1016/j.ejmech.2018.05.035
Autor:
Lusong Luo, Shuaishuai Chen, Haimei Xing, Sudan He, Haikuo Ma, Jiajun Li, Long Tai Zheng, Hongjian Zhang, Qin Chen, Xiaohu Zhang, Jiyue Zheng, Fang Zhu
Publikováno v:
European Journal of Medicinal Chemistry. 149:110-121
Embryonic stem cell pathways such as hedgehog and Wnt pathways are central to the tumorigenic properties of cancer stem cells (CSC). Since CSCs are characterized by their ability to self-renew, form differentiated progeny, and develop resistance to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50f5fbe5a816af0cdc9208245fade88
https://doi.org/10.1016/j.ejmech.2018.02.034
https://doi.org/10.1016/j.ejmech.2018.02.034
Autor:
Rui Wang, Fang Su, Fangquan Zhu, Zhengguang Zhou, Yawei Li, Fuyou Zhao, Qiong Wu, Hao Jin, Yurong Ou, Zhongwen Li, Jun Zhao, Wen Su, Yan Yang, Qiang Wang, Ze-nong Cheng, Jiyue Zheng, Yi Tan, Yumei Li, Shukui Qin
Publikováno v:
Oncotarget
// Fang Su 1, * , Jun Zhao 2, * , Shukui Qin 3 , Rui Wang 1 , Yumei Li 1 , Qiang Wang 4 , Yi Tan 5 , Hao Jin 5 , Fangquan Zhu 5 , Yurong Ou 6 , Zenong Cheng 6 , Wen Su 1 , Fuyou Zhao 1 , Yan Yang 1 , Zhengguang Zhou 1 , Jiyue Zheng 1 , Yawei Li 1 , Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b321cd35a644bd16b011eaec8e9b670e
http://europepmc.org/articles/PMC5410303
http://europepmc.org/articles/PMC5410303