Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Jiyong Hong"'
Autor:
Angela Rivera, Won Young Lim, Eunchong Park, Patrick A. Dome, Michael J. Hoy, Ivan Spasojevic, Sheng Sun, Anna Floyd Averette, Sergio Pina-Oviedo, Praveen R. Juvvadi, William J. Steinbach, Maria Ciofani, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Fungal infections are of mounting global concern, and the current limited treatment arsenal poses challenges when treating such infections. In particular, infections by Cryptococcus neoformans are associated with high mortality, emphasizing
Externí odkaz:
https://doaj.org/article/ce0b324bccb346759ee1b133f5211833
Autor:
Divya L. Dayanidhi, Jason A. Somarelli, John B. Mantyh, Gabrielle Rupprecht, Roham Salman Roghani, Sophia Vincoff, Iljin Shin, Yiquan Zhao, So Young Kim, Shannon McCall, Jiyong Hong, David S. Hsu
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/3ce819b3570744e6b93e60cc70e9e3ea
Autor:
Divya L. Dayanidhi, Jason A. Somarelli, John B. Mantyh, Gabrielle Rupprecht, Roham Salman Roghani, Sophia Vincoff, Iljin Shin, Yiquan Zhao, So Young Kim, Shannon McCall, Jiyong Hong, David S. Hsu
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Colorectal cancer (CRC) is the third most prevalent form of cancer in the United States and results in over 50,000 deaths per year. Treatments for metastatic CRC are limited, and therefore there is an unmet clinical need for more effective therapies.
Externí odkaz:
https://doaj.org/article/a7ae9050338a4bf4b109f13416c91426
Autor:
Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Calcineurin is an essential virulence factor that is conserved across human fungal pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans. Although an excellent target for antifungal drug development, the s
Externí odkaz:
https://doaj.org/article/117f01418524456e8457bbd3d23cdecf
Autor:
Ellene H. Mashalidis, Benjamin Kaeser, Yuma Terasawa, Akira Katsuyama, Do-Yeon Kwon, Kiyoun Lee, Jiyong Hong, Satoshi Ichikawa, Seok-Yong Lee
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Phospho-MurNAc-pentapeptide translocase (MraY) is a bacterial integral membrane enzyme that is essential for peptidoglycan biosynthesis. Here the authors present the crystal structures of MraY from Aquifex aeolicus bound to caprazamycin, capuramycin
Externí odkaz:
https://doaj.org/article/e0558f6d0eab41fcbb345629cf908792
Autor:
Jun-Kyu Byun, Sun Hee Lee, Eui Jung Moon, Myo-Hyeon Park, Hyeonha Jang, Douglas H. Weitzel, Hyun-Hwi Kim, Nikita Basnet, Do-Yeon Kwon, Chen-Ting Lee, Tesia N. Stephenson, Ji-Hak Jeong, Bhargav A. Patel, Sung Jean Park, Jen-Tsan Chi, Mark W. Dewhirst, Jiyong Hong, You Mie Lee
Publikováno v:
British Journal of Cancer. 128:1491-1502
Autor:
Seung‐Hwa Kwak, C. Skyler Cochrane, Jae Cho, Patrick A. Dome, Amanda F. Ennis, Jea Hyun Kim, Pei Zhou, Jiyong Hong
Publikováno v:
ChemMedChem.
Autor:
Jay Anand, Lilly Chiou, Carly Sciandra, Xingyuan Zhang, Jiyong Hong, Di Wu, Pei Zhou, Cyrus Vaziri
Publikováno v:
NAR Cancer. 5
DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The ‘Y-family’ trans-lesion synthesis (TLS) DNA polymerases enable cells to rep
Autor:
Nicholas J. Wright, Justin G. Fedor, Han Zhang, Pyeonghwa Jeong, Yang Suo, Jiho Yoo, Jiyong Hong, Wonpil Im, Seok-Yong Lee
Publikováno v:
Nature
Folates are essential nutrients with important roles as cofactors in one-carbon transfer reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of amino acids during cell division(1,2). Mammals lack de novo folate synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb6acad146e3b9c6c6a0783be0274b9
https://europepmc.org/articles/PMC9822521/
https://europepmc.org/articles/PMC9822521/
Autor:
Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio. 13
Due to rising rates of antifungal drug resistance and a limited armamentarium of antifungal treatments, there is a paramount need for novel antifungal drugs to treat systemic fungal infections. Calcineurin has been established as an essential and con