Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jiyeon Kweon"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 4, Pp 861-869 (2024)
Abstract Advances in sequencing technology have greatly increased our ability to gather genomic data, yet understanding the impact of genetic mutations, particularly variants of uncertain significance (VUSs), remains a challenge in precision medicine
Externí odkaz:
https://doaj.org/article/68dcc3db04674fbab61ba4df416a6cee
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-7 (2023)
Abstract KRAS is the most commonly mutated RAS family gene and is a primary cause of the occurrence of several types of cancer. However, KRAS mutations have several unique and diverse molecular identities, making it difficult to find specific treatme
Externí odkaz:
https://doaj.org/article/2faf4a85fb8f469a8e2220d1d90e7ad6
Autor:
Gayoung Jang, Ha Rim Shin, Hyo-Sang Do, Jiyeon Kweon, Soojin Hwang, Soyoung Kim, Sun Hee Heo, Yongsub Kim, Beom Hee Lee
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 586-595 (2023)
Lesch-Nyhan syndrome (LNS) is inherited as an X-linked recessive genetic disorder caused by mutations in hypoxanthine-guanine phosphoribosyl transferase 1 (HPRT1). Patients with LNS show various clinical phenotypes, including hyperuricemia, gout, dev
Externí odkaz:
https://doaj.org/article/eb6665589bc6414aa635932aaa3cb0f1
Autor:
Jiyeon Kweon, An-Hee Jang, Eunji Kwon, Ungi Kim, Ha Rim Shin, Jieun See, Gayoung Jang, Chaeyeon Lee, Taeyoung Koo, Seokjoong Kim, Yongsub Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 2, Pp 377-384 (2023)
Genome editing: Novel editors for CRISPR-Cas9 technology Tiny genome editors that can fit inside a single delivery system could potentially improve the efficiency and specificity of the editing technology known as CRISPR-Cas9. This technology is used
Externí odkaz:
https://doaj.org/article/5a3318fd8f0248789017a3d9b04bef91
Autor:
Eun-Young Kim, Ji-Eun Kim, Bongkun Choi, Jiyeon Kweon, Si-On Park, Hee-Seop Lee, Eun-Jin Lee, Soyoon Oh, Ha Rim Shin, Hyuksu Choi, Yongsub Kim, Eun-Ju Chang
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
TNF-α plays a crucial role in cancer initiation and progression by enhancing cancer cell proliferation, survival, and migration. Even though the known functional role of AWP1 (zinc finger AN1 type-6, ZFAND6) is as a key mediator of TNF-α signaling,
Externí odkaz:
https://doaj.org/article/244a86a65ec14995a730ec74a0c47b4f
Autor:
Jiyeon Kweon, An-Hee Jang, Da-eun Kim, Jin Wook Yang, Mijung Yoon, Ha Rim Shin, Jin-Soo Kim, Yongsub Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Cas9 and Cpf1 have both been adapted for genome engineering, editing and gene expression regulation. Here the authors design a fusion guide RNA that can interact with both proteins for multiple and orthogonal genome manipulation.
Externí odkaz:
https://doaj.org/article/71bb17bf76e3494bae0588923dad639c
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199473 (2018)
Pooled CRISPR libraries are widely used in high-throughput screening to study various biological processes. Various pooled CRISPR libraries have been shared for CRISPR screens and useful tools have been developed to construct researcher's own librari
Externí odkaz:
https://doaj.org/article/dbd18270198e429696a79d0959380995
Autor:
Jiyeon Kweon, An-Hee Jang, Da-eun Kim, Jin Wook Yang, Mijung Yoon, Ha Rim Shin, Jin-Soo Kim, Yongsub Kim
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this Article contained an error in the spelling of the author Da-eun Kim, which was incorrectly given as Da-Eun Kim. Furthermore, in Figure 1a, the Cas9 protein was positioned incorrectly during typesetting. These
Externí odkaz:
https://doaj.org/article/88cb80d74b594dc2828605231b64dd89
KRASis the most commonly mutated RAS family gene and is a primary cause of the occurrence of several types of cancer. However,KRASmutations have several unique and diverse molecular identities, making it difficult to find specific treatments. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6edd7d90fad31c5e69e46086f633112
https://doi.org/10.1101/2022.12.21.521522
https://doi.org/10.1101/2022.12.21.521522
Autor:
Jong Il Kim, Jung Ki Yoon, Yongsub Kim, An Hee Jang, Ha Rim Shin, Gayoung Jang, Ji Eun See, Jiyeon Kweon
Publikováno v:
Molecular Therapy. 29:2001-2007
Although prime editors are a powerful tool for genome editing, which can generate various types of mutations such as nucleotide substitutions, insertions, and deletions in the genome without double-strand breaks or donor DNA, the conventional prime e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7a5226cd3a227b9692f17fcbb95fca
https://doi.org/10.1016/j.ymthe.2021.02.022
https://doi.org/10.1016/j.ymthe.2021.02.022