Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jixiao Niu"'
Autor:
null Candida Fratazzi, null Jixiao Niu
Publikováno v:
World Journal of Advanced Pharmaceutical and Medical Research. 2:001-007
Today, orphan drug development is confronted with significant challenges represented by the considerable complexity, diversity of clinical manifestations, and competition in study recruitment. Thus, surrogate endpoints adoption plays a crucial role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7244132ff69ead45bc462d28c5b567c
https://doi.org/10.53346/wjapmr.2022.2.1.0021
https://doi.org/10.53346/wjapmr.2022.2.1.0021
Autor:
Baohui Zheng, Xu Wu, Yang Sun, Baoen Chen, Sarah R. Walker, Aaron N. Hata, Mari Mino-Kenudson, Jixiao Niu, David A. Frank, Gopala K. Jarugumilli
Publikováno v:
Nature
Signal transducer and activator of transcription 3 (STAT3) has a critical role in regulating cell fate, inflammation and immunity1,2. Cytokines and growth factors activate STAT3 through kinase-mediated tyrosine phosphorylation and dimerization3,4. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039ee124b5f2391e70f78e8d94b08f90
https://doi.org/10.1038/s41586-019-1511-x
https://doi.org/10.1038/s41586-019-1511-x
Publikováno v:
Cell Chemical Biology. 25:817-831
Protein lipidation is an important co- or posttranslational modification in which lipid moieties are covalently attached to proteins. Lipidation markedly increases the hydrophobicity of proteins, resulting in changes to their conformation, stability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59dd24ae809f86cf743c7d8a212b1f6
https://doi.org/10.1016/j.chembiol.2018.05.003
https://doi.org/10.1016/j.chembiol.2018.05.003
Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2-trans-Hexadecenal
Autor:
Jong-Ryoul Choi, Michael DeRan, Baoen Chen, Jixiao Niu, Gopala K. Jarugumilli, Yang Sun, PuiYee Chan, Meilan Yu, Xu Wu, Cheng Lin, Baohui Zheng, Raphael A. Zoeller
Publikováno v:
ACS Chemical Biology. 13:1130-1136
Lipid-derived electrophiles (LDEs) are reactive metabolites, which can covalently modify proteins and DNA and regulate diverse cellular processes. 2- trans-Hexadecenal (2-HD) is a byproduct of sphingolipid metabolism, involved in cytoskeletal reorgan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102f8579bc74f239dcc0d2deb0585f4
https://doi.org/10.1021/acschembio.7b01063
https://doi.org/10.1021/acschembio.7b01063
Autor:
Gopala K. Jarugumilli, Jixiao Niu, Yang Sun, Aaron N. Hata, Sarah R. Walker, Baoen Chen, Xu Wu, Mari Mino-Kenudson, Baohui Zheng, David A. Frank
Publikováno v:
Nature
Signal transducer and activator of transcription 3 (STAT3) has a critical role in regulating cell fate, inflammation and immunity1,2. Cytokines and growth factors activate STAT3 through kinase-mediated tyrosine phosphorylation and dimerization3,4. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c60e18b071f908c914ff8b2da65dedd
https://doi.org/10.1038/s41586-020-2414-6
https://doi.org/10.1038/s41586-020-2414-6
Autor:
Wilhelm Haas, Johannes Kreuzer, Jixiao Niu, Gopala K. Jarugumilli, Baohui Zheng, Xu Wu, Baoen Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Defects in cilia have been associated with an expanding human disease spectrum known as ciliopathies. Regulatory Factor X 3 (RFX3) is one of the major transcription factors required for ciliogenesis and cilia functions. In addition, RFX3 regulates pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a03f7226669597768f61230bb129012
https://doi.org/10.1073/pnas.1800949115
https://doi.org/10.1073/pnas.1800949115
Autor:
Jixiao Niu, Meiyun Fan, Guangyun Tan, Chuan He Yang, Lawrence M. Pfeffer, Yuling Shi, Zhao-Hui Wu
Publikováno v:
Journal of Biological Chemistry. 287:21783-21795
NF-κB activation induced by genotoxic treatment in cancer cells has been associated with therapeutic resistance in multiple human malignancies. Therapeutic resistance also correlates with high metastatic potential in human cancers, including breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33190159a6e4348175ca0b940a32e2d9
https://doi.org/10.1074/jbc.m112.355495
https://doi.org/10.1074/jbc.m112.355495
Publikováno v:
The EMBO Journal. 30:3741-3753
The transcription factor nuclear factor κB (NF-κB) regulates various cellular processes such as inflammation and apoptosis. The NF-κB essential modulator (NEMO/IKKγ) is indispensable for NF-κB activation by diverse stimuli including genotoxic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cef4243c037f1af41fc411b03d3d749
https://doi.org/10.1038/emboj.2011.264
https://doi.org/10.1038/emboj.2011.264
Publikováno v:
Cancer Research. 78:533-533
Triple-negative breast cancer (TNBC) or Basal-like breast cancer is characterized by worse prognosis than other breast cancer subtypes due to the rapid-arising therapeutic resistance accompanied by aggressive metastasis. The therapy-resistant tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3920501840992c29ade1ac6ab1bb636
https://doi.org/10.1158/1538-7445.am2018-533
https://doi.org/10.1158/1538-7445.am2018-533
Autor:
Dong Van Quyen, Nikhlesh K. Singh, Qiuhua Zhang, Saradasri Karri, Jaganathan Subramani, Venkatesh Kundumani-Sridharan, Gadiparthi N. Rao, Jixiao Niu, Dong Wang
Publikováno v:
Blood. 115:2105-2116
To understand the mechanisms underlying 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE]–induced angiogenesis, we studied the role of Egr-1. 15(S)-HETE induced Egr-1 expression in a time-dependent manner in human dermal microvascular endothelial cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a653e85dbdbd485ec4c90ea85dfdd2f
https://doi.org/10.1182/blood-2009-09-241802
https://doi.org/10.1182/blood-2009-09-241802