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Akademický článek

Integrated energy conversion units in nanoscale frameworks induce sustained generation and amplified lethality of singlet oxygen in oxidative therapy of tumor

Autor: Jing Zhu, Tao Ding, Kaifei Jin, Yuxin Xing, Jixi Huang, Daqing Xia, Kaiyong Cai, Jixi Zhang

Publikováno v: View, Vol 3, Iss 6, Pp n/a-n/a (2022)

Abstract Reactive oxygen species (ROS) driven endoplasmic reticulum (ER) stress is highly promising for tumor therapy but restrained by the nondurable introduction and limited lifetime of oxidative species. Here, a therapeutic nanosystem with sustain

Externí odkaz: https://doaj.org/article/d41d81cda6db406d998976f1d0d488ad

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Combination wound healing using polymer entangled porous nanoadhesive hybrids with robust ROS scavenging and angiogenesis properties

Autor: Jixi Huang, Shuai Wang, Xiaoping Wang, Jing Zhu, Zhenqiang Wang, Ximu Zhang, Kaiyong Cai, Jixi Zhang

Publikováno v: Acta Biomaterialia. 152:171-185

Nanoadhesives can achieve tight wound closure by connecting biomacromolecules from both sides. However, previously developed adhesive systems suffered from suboptimal wound healing efficiency due to the lack of interparticle cohesion, sufficient reac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5db694c6b990b0c306579d9886d1bd
https://doi.org/10.1016/j.actbio.2022.08.069

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Photothermally triggered melting and perfusion: responsive colloidosomes for cytosolic delivery of membrane-impermeable drugs in tumor therapy

Autor: Tao Ding, Jing Zhu, Haidi Guan, Daqing Xia, Yuxin Xing, Jixi Huang, Zhenqiang Wang, Kaiyong Cai, Jixi Zhang

Publikováno v: Journal of Materials Chemistry B. 10:1103-1115

A cell membrane barrier which dominates the therapeutic efficacy and systemic side effects is a major bottleneck in the field of drug delivery. Herein, a therapeutic system capable of photothermally triggered on-demand and cytosolic delivery was achi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293890c47b8de442cfdf12ca7ae76d12
https://doi.org/10.1039/d1tb02503a

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Melanin Nanoparticle-Actuated Redox-State Perturbation and Temporally Photoactivated Thermal Stress for Synergistic Tumor Therapy

Autor: Hanyin Zhu, Yongyi Qu, Shuai Wang, Jixi Huang, Jing Zhu, Lu Wang, Kaiyong Cai, Jixi Zhang

Publikováno v: ACS biomaterials scienceengineering. 8(9)

The elevation of antioxidant defense systems by adaptation response to localized reactive oxygen species (ROS) accumulation may confer resistance to excessive oxidative stress and cause therapeutic lethality. Herein, a highly effective tumor therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d1a9186cbc8d958914d41d0a23b79f
https://pubmed.ncbi.nlm.nih.gov/36001109

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Redox Host-Guest Nanosensors Installed with DNA Gatekeepers for Immobilization-Free and Ratiometric Electrochemical Detection of miRNA

Autor: Xiyue Xie, Meizhen Zhou, Yuhua Chen, Kaiyong Cai, Zhenqiang Wang, Jixi Zhang, Jixi Huang, Yuxin Xing

Publikováno v: Small methods. 5(12)

Electrochemical nanosensors by integrating functional nucleic acids and nanomaterials hold a great promise in the fast detection of biomarkers, yet the current systems possess limitations on the accessibility of target-probe and probe-electrode inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02476831093658427bb45dabd3af23a6
https://pubmed.ncbi.nlm.nih.gov/34928007

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